公开(公告)号：EP1067869B1

公开(公告)日：2005-11-02

申请号：EP99916238.1

申请日：1999-03-31

申请人： Transvascular, Inc.

发明人： FLAHERTY, J., Christopher ,  WHITT, Jason, B. ,  CHANG, John, Y. ,  THOLFSEN, David, R. ,  EVARD, Phillip, C.

IPC分类号： A61B17/22

CPC分类号： A61M25/0108 ,  A61B17/22 ,  A61B17/3207 ,  A61B2017/00252 ,  A61B2017/00455 ,  A61B2017/22077 ,  A61B2090/3784 ,  A61B2090/3925

摘要： A catheter device (11) that is useable to penetrate from a blood vessel in which the catheter device (11) is positioned to a target location, comprises a flexible catheter advanced into the blood vessel, a tissue penetrator (85) which is useable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter includes an imaging transducer (81) fixedly mounted on or within the catheter body (13) to provide an imaging signal from which an image of the target location can be obtained. The catheter device (11) may include an imaged marker (101) on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator (85) exits from the catheter (11). Alternatively, or in addition thereto, the imaging transducer (81) may comprise a plurality of imaging elements.

公开(公告)号：EP1047341A1

公开(公告)日：2000-11-02

申请号：EP98931643.5

申请日：1998-06-25

申请人： Transvascular, Inc.

发明人： MAKOWER, Joshua ,  FLAHERTY, Christopher, J. ,  MACHOLD, Timothy, R. ,  GARIBOTTO, John, Thomas ,  WHITT, Jason, Brian

IPC分类号： A61B17/08

CPC分类号： A61B17/11 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/06 ,  A61B17/064 ,  A61B17/12 ,  A61B17/12013 ,  A61B2017/00292 ,  A61B2017/00557 ,  A61B2017/00946 ,  A61B2017/0409 ,  A61B2017/0419 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/06047 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139

摘要： A method and apparatus for passing attachment apparatus (20), (e.g., connector devices, staples, etc.) or connector material (88), (e.g., suture thread, wire, cord, filament, monofilament, etc.) into or through the wall of a luminal anatomical structure (e.g., a blood vessel or other anatomical conduit), for the purpose of closing the lumen of the anatomical structure, forming an anastomotic junction between separate anatomical structures (or between approximated segments of the same anatomical structure), and/or attaching an article (e.g., an endoluminal, extraluminal or transluminal graft) or other apparatus to the wall of the anatomical structure.

公开(公告)号：EP0981295A4

公开(公告)日：2005-02-02

申请号：EP98915524

申请日：1998-04-13

申请人： TRANSVASCULAR INC

发明人： MAKOWER JOSHUA ,  FLAHERTY J CHRISTOPHER ,  MACHOLD TIMOTHY R ,  WHITT JASON BRIAN ,  TUMAS MARGARET W ,  LAMSON THEODORE C ,  JENSEN MARC

IPC分类号： A61B17/00 ,  A61B17/064 ,  A61B17/11 ,  A61B17/12 ,  A61B17/30 ,  A61B17/34 ,  A61B18/00 ,  A61B18/14 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/24 ,  A61F2/90 ,  A61F2/94 ,  A61L27/00 ,  A61M25/00 ,  A61M39/24 ,  A61F2/06 ,  A61F2/14 ,  A61M1/12 ,  A61M29/02

CPC分类号： A61B17/00234 ,  A61B17/00491 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12131 ,  A61B17/12136 ,  A61B17/12172 ,  A61B17/3417 ,  A61B18/00 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/40 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/00504 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61B2017/12127 ,  A61B2017/306 ,  A61B2017/347 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61F2/07 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2421 ,  A61F2/2475 ,  A61F2/2493 ,  A61F2/90 ,  A61F2/94 ,  A61F2002/30079 ,  A61F2210/009 ,  A61F2220/0008 ,  A61M39/24 ,  A61M2025/0076 ,  A61M2025/1052

摘要： Methods and apparatus for direct coronary revascularization wherein a transmyocardial passageway is formed between a chamber of the heart and a coronary blood vesel to permit blood to flow therebetween. In some embodiments, the transmyocardial passageway is formed between a chamber of the heart and a coronary vein. The invention includes unstented transmyocardial passageways, as well as transmyocardial passageways wherein protrusive stent devices extend from the transmyocardial passageway into an adjacent coronary vessel or chamber of the heart. The apparatus of the present invention include protrusive stent devices for stenting of transmyocardial passageways, intraluminal valving devices for valving of transmyocardial passageways, intracardiac valving devices for valving of transmyocardial passageways, endogenous tissue valves for valving of transmyocardial passageways, and ancillary apparatus for use in conjunction therewith.

公开(公告)号：EP0932426A4

公开(公告)日：2003-07-30

申请号：EP97904086

申请日：1997-01-31

申请人： TRANSVASCULAR INC

发明人： EVARD PHILIP C ,  FLAHERTY J C ,  GARIBOTTO JOHN T ,  MACAULAY PATRICK E ,  MACHOLD TIMOTHY R ,  MAKOWER JOSHUA ,  WHITT JASON B ,  ROTH ALEX T

IPC分类号： A61B1/313 ,  A61B17/00 ,  A61B17/064 ,  A61B17/11 ,  A61B17/12 ,  A61B17/22 ,  A61B17/30 ,  A61B17/34 ,  A61B18/00 ,  A61B18/14 ,  A61B18/24 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/90 ,  A61M25/00

CPC分类号： A61B1/3137 ,  A61B17/00234 ,  A61B17/00491 ,  A61B17/0643 ,  A61B17/11 ,  A61B18/00 ,  A61B18/1445 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/24 ,  A61B90/361 ,  A61B90/40 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/00504 ,  A61B2017/0641 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/22038 ,  A61B2017/22077 ,  A61B2018/00392 ,  A61B2018/00404 ,  A61B2018/00869 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61F2/07 ,  A61F2/2493 ,  A61F2/90 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/30079 ,  A61F2002/8486 ,  A61F2210/009 ,  A61F2230/001 ,  A61M2025/0076 ,  A61M2025/0096 ,  A61M2025/1052

摘要： Anastomotic connectors and apparatus for forming and/or maintaining connections between openings formed in anatomical structures, such as blood vessels. The apparatus is initially deployed in a first configuration which is sufficiently compact to be delivered through the lumen of a catheter or cannula. Thereafter, the device is expanded to a second configuration whereby it engages the anatomical structures and forms or maintains the desired connection between openings in the anatomical structures.

公开(公告)号：EP1037571A4

公开(公告)日：2003-05-28

申请号：EP98957744

申请日：1998-11-10

申请人： TRANSVASCULAR INC

发明人： KIM STEVEN ,  FLAHERTY J CHRISTOPHER ,  WHITT JASON BRIAN ,  LAMSON THEODORE C ,  MAKOWER JOSHUA

IPC分类号： A61B17/00 ,  A61B17/064 ,  A61B17/11 ,  A61B17/12 ,  A61B17/30 ,  A61B17/34 ,  A61B18/00 ,  A61B18/14 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61F2/82 ,  A61F2/90 ,  A61M25/00 ,  A61M25/095

CPC分类号： A61F2/91 ,  A61B17/00491 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/3417 ,  A61B18/00 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/40 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/00504 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/12127 ,  A61B2017/306 ,  A61B2017/347 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61F2/064 ,  A61F2/07 ,  A61F2/2493 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/061 ,  A61F2002/30079 ,  A61F2002/825 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2210/009 ,  A61F2230/0054 ,  A61F2250/0048 ,  A61M2025/0076 ,  A61M2025/009 ,  A61M2025/1052

摘要： Implantable connector devices (10) which are useable to maintain fluidic connection between or approximation of, openings formed in adjacent natural or prosthetic anatomical conduits (or adjacent openings formed in a single anatomical conduit). These connector devices (10) generally comprise a plurality of radially expandable annular members (12a-12c) having one or more elongate strut members (14) extending therebetween. Initially, the device (10) is mountable on or within a delivery catheter while in a radially compact configuration. After the delivery catheter has been inserted into the body, the device is caused to transition to a radially expanded configuration whereby it becomes implanted within the body so as to maintain the desired fluidic connection between, or the desired approximation of, the anatomical conduit(s).

公开(公告)号：EP1253859A1

公开(公告)日：2002-11-06

申请号：EP01900873.9

申请日：2001-01-03

申请人： Transvascular, Inc.

发明人： FLAHERTY, J., Christopher ,  EVARD, Philip, C. ,  ACOSTA, Pablo, G., Jr. ,  MACAULAY, Patrick, E. ,  LAMSON, Theodore, C.

IPC分类号： A61B17/11 ,  A61B17/32 ,  A61B17/34

CPC分类号： A61B17/3207 ,  A61B17/11 ,  A61B17/320016 ,  A61B18/14 ,  A61B2017/00252 ,  A61B2017/1139

摘要： Apparatus (10) for creating channels between adjacent blood vessels include a cutting element (22) fixed on a catheter (12) for creating a channel in a wall of a blood vessel. A clip (34) engages tissue thereunder for maintaining the cutting element (22) in contact with tissue being cut. Orientation markers (32, 33) may facilitate rotationally orienting the cutting element (22). The catheter (12) is advanced into a blood vessel, and a distal portion (24) of the catheter (12) is directed through a wall of the vessel towards an adjacent vessel until the cutting element (22) is in contact with tissue therebetween. The catheter (12) is directed axially along the vessel, thereby creating a channel in the tissue using the cutting element (22). In another embodiment, the apparatus (310) may include first and second elongated elements (326a, 326b) pivotably coupled to one another having an aperture-creating assembly (322) disposed between them.

公开(公告)号：EP1069869A1

公开(公告)日：2001-01-24

申请号：EP99916412.2

申请日：1999-04-06

申请人： Transvascular, Inc.

发明人： ROTH, ALEX, T. ,  FLAHERTY, J., Christopher ,  JOHNSON, Adrian, E. ,  MAKOWER, Joshua ,  WHITT, Jason, Brian

IPC分类号： A61D17/00

CPC分类号： A61B17/32075 ,  A61B17/32002 ,  A61B18/1482 ,  A61B18/245 ,  A61B2017/00252 ,  A61B2017/22069 ,  A61B2018/2255 ,  A61B2018/2266 ,  A61B2018/2272 ,  A61B2090/036 ,  A61B2090/065 ,  A61M25/104

摘要： This invention is methods, apparatus, and systems for enlarging interstitial penetration tracts which have been formed between blood vessels or elsewhere within the body of a mammalian patient. Included are de-bulking type tract enlarging systems (10, 10a), dilation-type tract enlarging systems (10b), tissue-sclicing-type tract enlarging systems (10c), and two-catheter-type tract enlarging systems (17).

公开(公告)号：EP0964636A1

公开(公告)日：1999-12-22

申请号：EP98920833.0

申请日：1998-04-10

申请人： Transvascular, Inc. ,  Makower, Joshua

发明人： MAKOWER, Joshua ,  FLAHERTY, J., Christopher ,  MACHOLD, Timothy, R. ,  WHITT, Jason, Brian ,  EVARD, Philip, Christopher ,  MACAULAY, Patrick, Edward ,  GARIBOTTO, John, Thomas ,  TUMAS, Margaret, W. ,  SELFRIDGE, Alan, Robert

IPC分类号： A61B17 ,  A61B1 ,  A61B8 ,  A61B18 ,  A61M25 ,  A61B19 ,  A61F2 ,  A61M29

CPC分类号： A61B17/3439 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B17/00491 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/3207 ,  A61B17/3417 ,  A61B18/00 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B90/40 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/003 ,  A61B2017/00504 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/12127 ,  A61B2017/22067 ,  A61B2017/22068 ,  A61B2017/22069 ,  A61B2017/22072 ,  A61B2017/306 ,  A61B2017/347 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61B2090/0811 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61F2/2493 ,  A61F2002/30079 ,  A61F2210/009 ,  A61M25/0084 ,  A61M25/0141 ,  A61M25/0147 ,  A61M25/0155 ,  A61M29/00 ,  A61M29/02 ,  A61M2025/0076 ,  A61M2025/009 ,  A61M2025/1052

摘要： The inventions described in this patent application include i) a torqueable introducer sheath which is useable in conjunction with a transvascular passageway forming catheter to effect precise rotational control of the catheter; ii) an anchorable guide catheter which is useable in conjunction with an intravascular imaging catheter and a transvascular passageway-forming catheter to effect precise positioning and aiming of the passageway-forming catheter; iii) a passageway forming catheter having a torqueable proximal portion to facilitate precise rotational positioning of the distal portion of the catheter; iv) a deflectable-tipped passageway forming catheter, v) various markers and other apparatus useable in conjunction with any of the passageway-forming catheters to facilitate precise positioning and aiming of the catheter, and vi) an apparatus which may be formed within a catheter to prevent a member, apparatus of flow of material from being inadvertently advanced through a lumen of the catheter.

公开(公告)号：EP0879068A4

公开(公告)日：1999-04-21

申请号：EP97904084

申请日：1997-01-31

申请人： TRANSVASCULAR INC

发明人： EVARD PHILIP C ,  FLAHERTY J C ,  GARIBOTTO JOHN T ,  MACAULAY PATRICK E ,  MACHOLD TIMOTHY R ,  MAKOWER JOSHUA ,  WHITT JASON B ,  JENSEN MARC

IPC分类号： A61B1/313 ,  A61B17/00 ,  A61B17/064 ,  A61B17/11 ,  A61B17/12 ,  A61B17/22 ,  A61B17/30 ,  A61B17/34 ,  A61B18/00 ,  A61B18/14 ,  A61B18/24 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/90 ,  A61M25/00 ,  A61M19/00

CPC分类号： A61B1/3137 ,  A61B17/00234 ,  A61B17/00491 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12131 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/3417 ,  A61B17/3496 ,  A61B18/00 ,  A61B18/1445 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/24 ,  A61B90/361 ,  A61B90/40 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/00504 ,  A61B2017/0641 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/1205 ,  A61B2017/12127 ,  A61B2017/22038 ,  A61B2017/22077 ,  A61B2017/306 ,  A61B2017/347 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2018/00404 ,  A61B2018/00869 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61F2/07 ,  A61F2/2493 ,  A61F2/90 ,  A61F2/95 ,  A61F2002/075 ,  A61F2002/30079 ,  A61F2002/8486 ,  A61F2210/009 ,  A61M2025/0076 ,  A61M2025/0096 ,  A61M2025/1052

摘要： This invention is methods and apparatus for occluding blood flow within a blood vessel (22). In a first series of embodiments, the present invention comprises a plurality of embolic devices (16) deployable through the lumen (12) of a conventional catheter (10) such that when deployed, said embolic devices (16) remain resident and occlude blood flow at a specific site within the lumen of the blood vessel (22). Such embolic devices (16) comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso-occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure. In a third series of embodiments, the present invention comprises the combination of an embolization facilitator coupled with the application of an energy force to form an intraluminal closure at a specified site within a vessel.

公开(公告)号：EP1066070A4

公开(公告)日：2009-08-05

申请号：EP99909978

申请日：1999-03-17

申请人： TRANSVASCULAR INC

发明人： FLAHERTY J CHRISTOPHER ,  MAKOWER JOSHUA ,  EVARD PHILIP C ,  MACAULAY PATRICK E ,  WHITT JASON B ,  COLLOTON ROBERT C ,  MACFARLANE K ANGELA

IPC分类号： A61B8/12 ,  A61B17/00 ,  A61B17/064 ,  A61B17/11 ,  A61B17/12 ,  A61B17/22 ,  A61B17/30 ,  A61B17/34 ,  A61B18/00 ,  A61B18/14 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/958 ,  A61M25/00 ,  A61M25/095 ,  A61M39/02 ,  A61M39/04 ,  A61M5/00 ,  A61M5/178

CPC分类号： A61M25/0084 ,  A61B8/12 ,  A61B17/00491 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12172 ,  A61B17/22 ,  A61B17/3417 ,  A61B18/00 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/40 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/00504 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/12127 ,  A61B2017/22077 ,  A61B2017/306 ,  A61B2017/347 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61F2/2493 ,  A61F2002/30079 ,  A61F2210/009 ,  A61M5/007 ,  A61M5/46 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/007 ,  A61M25/0108 ,  A61M39/0208 ,  A61M39/04 ,  A61M2025/0037 ,  A61M2025/0076 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2025/0096 ,  A61M2025/1052

摘要： A trans-vascular system (10) for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter (12) having a distal portion (26) with puncturing (14), orientation (16), drug delivery (62), and imaging elements (18). The puncturing element (14) is deployed for penetrating the vessel wall to access the tissue region. The orientation element (16), e.g., a 'cage' including a plurality of struts (38, 40), and/or a radiopaque marker has a predetermined relationship with the location of the orientation element (16) with respect to the tissue region to orient the puncturing element (14). The catheter (12) is percutaneously introducing into the vessel, the puncturing element (14) is oriented towards the tissue region, the puncturing element (14) is deployed to access the tissue region, and the drug is delivered to the tissue region. An ablation device (230) may also be deployed to create a cavity in the tissue region for receiving the drug therein, or an indwelling catheter (214) may be advanced into, and left in the tissue region. An implanted reservoir device (350) is also disclosed, including an enclosed membrane (354) on an expandable frame (352) that defines a reservoir, and includes a porous region. The reservoir device may be deployed, expanded within a blood vessel, and may be filled in situ or pre-filled with a drug that passes through the porous region. Alternatively, a pair of expandable endovascular blockers may be used to isolate a section of a blood vessel which may be filled with a drug that may be absorbed by the surrounding tissue.