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公开(公告)号：EP3942318B1
公开(公告)日：2024-11-13
申请号：EP20726999.4
申请日：2020-04-24
IPC分类号： G01R33/56 , A61B5/00 , A61B5/055 , G01R33/563 , G01R33/565
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公开(公告)号：EP4440610A1
公开(公告)日：2024-10-09
申请号：EP22831051.2
申请日：2022-11-29
申请人： Sanofi Pasteur, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： CHAN, Yvonne , SASMAL, Sukanya , STUEBLER, Antonia , KISHKO, Michael , MUNDLE, Sophia , ZHANG, Linong , DINAPOLI, Josh , ALAMARES-SAPUAY, Judith , ANOSOVA, Natalie , CHIVUKULA, Sudha , DANZ, Hillary , STRUGNELL, Tod , GROPPO, Rachel , COLLINS, Peter , BUCHHOLZ, Ursula , MUNIR, Shirin , DAHAL, Bibha
IPC分类号： A61K39/12 , A61K39/155 , A61P11/00 , A61P31/14 , C07K14/005
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3.发明授权
公开(公告)号：EP3102609B1
公开(公告)日：2024-08-28
申请号：EP15746399.3
申请日：2015-02-04
IPC分类号： C12N5/0783 , A61K39/00 , A61K38/17 , C07K14/725 , A61P35/00
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公开(公告)号：EP4395899A1
公开(公告)日：2024-07-10
申请号：EP22777538.4
申请日：2022-08-30
发明人： BROGNARD, John F. , SWENSON, Rolf E. , FUNK, Amy L. , HITKO, Carolyn W. , NYSWANER, Katherine M. , BERGMAN, Knickole L. , SABBASANI, Venkatareddy , LINDBERG, Eric , CAPPELL, Steven D. , KATERJI, Meghri
IPC分类号： A61P35/00 , C07D401/12 , C07D401/14 , C07D487/08 , A61K31/4427
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D471/08 , C07D487/08 , C07D401/12 , C07D471/04 , A61P35/00 , A61P37/00
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公开(公告)号：EP4380921A1
公开(公告)日：2024-06-12
申请号：EP22761746.1
申请日：2022-08-03
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , The University of North Carolina at Chapel Hill
发明人： GANDHI, Disha , FRANKOWSKI, Kevin , FERRER, Marc , FREE, R. Benjamin , SIBLEY, David R. , MORITZ, Amy E. , SOUTHALL, Noel Terrence , HU, Xin , KELLEY, Amber
IPC分类号： C07D207/416 , A61P25/18 , A61P25/30 , A61K31/40
CPC分类号： C07D207/416 , A61P25/30 , A61P25/18
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公开(公告)号：EP4380613A1
公开(公告)日：2024-06-12
申请号：EP22758403.4
申请日：2022-08-02
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公开(公告)号：EP4374928A2
公开(公告)日：2024-05-29
申请号：EP24155493.0
申请日：2018-04-26
申请人： The Brigham And Women's Hospital Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： YU, Paul B. , HUANG, Wenwei , SANDERSON, Paul B. , JIANG, Jian-kang , SHAMIM, Khalida , ZHENG, Wei , HUANG, Xiuli , TAWA, Gregory , LEE, Arthur , ALIMARDANOV, Asaf , HUANG, Junfeng
IPC分类号： A61P43/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61P35/04 , A61P35/00 , A61P37/00 , A61P19/02 , A61P43/00 , A61P19/08 , A61K45/06
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
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公开(公告)号：EP4366772A1
公开(公告)日：2024-05-15
申请号：EP22838435.0
申请日：2022-07-07
申请人： Singh Biotechnology, LLC , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： SINGH, Sunanda , EGWUAGU, Charles
IPC分类号： A61K39/395 , A61P27/02
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公开(公告)号：EP4359432A2
公开(公告)日：2024-05-01
申请号：EP22743679.7
申请日：2022-06-22
IPC分类号： C07K14/775 , A61P3/10 , A61P3/06 , A61P9/00 , A61K38/00
CPC分类号： C07K14/775 , A61K38/00 , A61P3/06 , A61P9/00
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公开(公告)号：EP3849604B1
公开(公告)日：2024-05-01
申请号：EP19859381.6
申请日：2019-09-10
IPC分类号： A61K39/395 , A61K31/505 , C07K16/26 , C12N15/44 , C12N15/45 , A61K38/16
CPC分类号： C07K16/26 , A61K31/505 , C07K2317/7620130101 , A61K2039/50520130101 , A61P31/16 , A61K38/16
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