公开(公告)号：EP4434535A2

公开(公告)日：2024-09-25

申请号：EP24183144.5

申请日：2015-05-08

申请人： Universiteit Utrecht Holding B.V.

发明人： HAAGSMAN, Hendrik Peter ,  VAN DIJK, Albert ,  VELDHUIZEN, Edwin Johannes Adrianus

IPC分类号： A61K38/17

CPC分类号： A61K38/00 ,  C07K14/465 ,  A61P3/02 ,  A61P31/00 ,  A61P31/04 ,  A61P37/04 ,  A61P43/00

摘要： The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverse and retro-inverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.

公开(公告)号：EP4396325A1

公开(公告)日：2024-07-10

申请号：EP22772908.4

申请日：2022-09-01

申请人： Universiteit Utrecht Holding B.V.

发明人： SCHNEEBERGER, Kerstin ,  SPEE, Bart ,  VAN TIENDEREN, Gilles Sebastiaan ,  YE, Shicheng

IPC分类号： C12M1/06 ,  B01F27/191 ,  C12M1/34

CPC分类号： C12M27/02 ,  C12M41/42 ,  B01F27/191 ,  B01F27/90 ,  B01F33/813 ,  B01F33/86

公开(公告)号：EP3853237B1

公开(公告)日：2024-04-24

申请号：EP19828850.8

申请日：2019-09-20

IPC分类号： C07F9/572 ,  C07F9/6558 ,  G01N33/68 ,  C07K1/107

CPC分类号： G01N33/68 ,  G01N33/6845 ,  G01N33/6848 ,  C07K1/1077 ,  C07F9/572 ,  C07F9/65583

公开(公告)号：EP3615549A1

公开(公告)日：2020-03-04

申请号：EP18717953.6

申请日：2018-04-24

申请人： Universiteit Utrecht Holding B.V. ,  UMC Utrecht Holding B.V.

发明人： VAN EIJK, Marinus ,  VAN DIJK, Albert ,  HAAGSMAN, Hendrik Peter ,  VAN DER ENT, Cornelis Korstiaan

IPC分类号： C07K7/08 ,  C07K14/00 ,  A61K38/10

公开(公告)号：EP3193920B1

公开(公告)日：2020-02-19

申请号：EP15763592.1

申请日：2015-09-16

申请人： Humboldt-Universität zu Berlin ,  Universiteit Utrecht Holding B.V.

发明人： GUPTA, Nishith ,  ARROYO-OLARTE, Ruben ,  LUCIUS, Richard ,  BROUWERS, Jos ,  HELMS, J. Bernd ,  DUNAY, Ildiko

IPC分类号： A61K39/02 ,  A61K35/68 ,  C12N9/12 ,  A61K39/012 ,  A61K39/00 ,  C12N1/10 ,  C12N1/36 ,  C07F9/10

公开(公告)号：EP3150627B1

公开(公告)日：2018-11-21

申请号：EP16197733.5

申请日：2010-02-12

申请人： Universiteit Utrecht Holding B.V.

发明人： Bikker, Floris Jacob ,  van Dijk, Albert ,  Mars-Groenendijk, Rosalia ,  Veldhuizen, Edwin Johannes Adrianus ,  van der Kleij, Desiree ,  Haagsman, Hendrik ,  Molhoek, Elisabeth Margaretha

IPC分类号： C07K14/465 ,  A61K38/17 ,  A61K39/39 ,  C07K7/08 ,  C07K14/47 ,  A61P31/04

CPC分类号： C07K14/465 ,  A61K39/39 ,  A61K2039/55516 ,  C07K7/08 ,  C07K14/47

摘要： The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.

公开(公告)号：EP3191125A1

公开(公告)日：2017-07-19

申请号：EP15762993.2

申请日：2015-09-11

申请人： Intervet International B.V. ,  Universiteit Utrecht Holding B.V.

发明人： BORN VAN DEN, Erwin ,  BOSCH, Berend Jan ,  ROTTIER, Peter

IPC分类号： A61K39/215 ,  C07K14/165 ,  A61K39/39

CPC分类号： A61K39/215 ,  A61K39/00 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55511 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N7/00 ,  C12N2770/20034 ,  C12N2770/20071

摘要： The present invention pertains to a vaccine for use in protecting offspring of a sow against an infection with porcine endemic diarrhea virus (PEDV), the vaccine comprising non-live PEDV antigen and an oil containing adjuvant, by administration of the vaccine to the pregnant sow at a dose of the antigen corresponding to at least 3.0E6 TCID50 killed whole PEDV. The invention also pertains to a method of protecting young piglets against an infection with porcine endemic diarrhea virus (PEDV).

摘要翻译： 本发明涉及用于保护母猪后代免受猪地方性腹泻病毒（PEDV）感染的疫苗，所述疫苗包含非活PEDV抗原和含油佐剂，通过向怀孕母猪施用疫苗 一定剂量的抗原对应于至少3.0E6 TCID50杀死的完整PEDV。 本发明还涉及保护幼猪不受猪流行性腹泻病毒（PEDV）感染的方法。

公开(公告)号：EP2712357A1

公开(公告)日：2014-04-02

申请号：EP12726758.1

申请日：2012-05-18

申请人： PamGene B.V. ,  Universiteit Utrecht Holding B.V.

发明人： RUIJTENBEEK, Robby ,  VAN AMEIJDE, Jeroen ,  LISKAMP, Robertus Matthias Joseph

IPC分类号： C07C305/24 ,  C07F9/12 ,  C07K7/04 ,  C07K7/06 ,  G01N33/68

CPC分类号： G01N33/573 ,  C07C305/24 ,  C07F9/08 ,  C07F9/12 ,  C12Q1/42

摘要： The present invention relates to a method and tools which allow the kinetic monitoring of hydrolase enzyme activity. The present invention also aims to provide synthetic peptides and peptide residues modified such that they can be used in assays for monitoring hydrolase enzyme activity, and preferably phosphatase activity. Also claimed are modified tyrosine amino acid derivatives of formula (IV), wherein Y is chosen from —POy2− with y equal to 2 or 3 and esters thereof, —SOz− with z equal to 2 or 3 and esters thereof, a carbohydrate or carbohydrate derivatives; and; wherein X1 and/or X2 is selected from —N3, —NO2, —CI, or —CN, —SCN, a C1 to C8 alkyl, or H, wherein either X1 or X2 is not H.

摘要翻译： 本发明涉及一种方法和工具，其允许水解酶活性的动力学监测。 因此，本发明旨在提供合成的肽和肽残基改性寻求thatthey可以在测定法用于监测水解酶的活性，并优选磷酸酶活性。 所以要求保护的是改性的式（IV），worin Y选自-POy2-选择其中y等于2或3以及它们的酯的酪氨酸氨基酸衍生物，-SOz-其中z等于2或3以及它们的酯，碳水化合物或 碳水化合物衍生物; 和; worin X1和/或X2选自-N 3中选择，-NO 2，CI，或CN，SCN，一个C1-C8烷基，或H，worin X 1或X 2不为H.

公开(公告)号：EP2699689A1

公开(公告)日：2014-02-26

申请号：EP12774625.3

申请日：2012-04-20

申请人： Universiteit Utrecht Holding B.V. ,  The Rockefeller University

发明人： FISCHETTI, Vincent, A. ,  SCHMITZ, Jonathan ,  GILMER, Daniel ,  WAGENAAR, Jacob, Anthony ,  STEGEMAN, Jan, Arend

IPC分类号： C12P21/06

CPC分类号： A61K38/164 ,  A61K38/47 ,  C12Y302/01017

公开(公告)号：EP2421889A1

公开(公告)日：2012-02-29

申请号：EP10717314.8

申请日：2010-04-20

申请人： Universiteit Utrecht Holding B.V. ,  Stichting voor de Technische Wetenschappen

发明人： OHM, Robin Arthur ,  DE JONG, Jan, Fokke ,  LUGONES, Luis, Gaston ,  WÖSTEN, Herman, Abel, Bernard

IPC分类号： C07K14/375

CPC分类号： C07K14/375

摘要： The invention relates to a fungus or a mushroom and to a method of producing it wherein the fungus/mushroom has an increased expression level of a polypeptide and/or has a decreased expression level of a polypeptide, wherein the polypeptide comprises an amino acid sequence that has at least 40% amino acid identity or similarity with a sequence selected from SEQ ID NO:1-200 and/or that has at least 50% amino acid identity or similarity with a sequence selected from SEQ ID NO:201-208.