公开(公告)号：EP2981275B1

公开(公告)日：2019-01-09

申请号：EP14715256.5

申请日：2014-03-31

申请人： Sanofi-Aventis Deutschland GmbH

发明人： BONI, Julia ,  PLOHMANN, Bernd ,  SAUERLAND, Sandra

IPC分类号： A61K36/09 ,  A61P1/04

公开(公告)号：EP3016635A1

公开(公告)日：2016-05-11

申请号：EP14759283.6

申请日：2014-07-01

申请人： Aventisub LLC

发明人： AMITH, Kumar ,  DILIP, Prajapati ,  KUM, Prasad ,  PRAVEEN, Khullar ,  RAMESH, Kumar

IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K31/445 ,  A61P11/00

CPC分类号： A61K31/445 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K47/10 ,  A61K47/26

摘要： The present invention relates to a liquid pharmaceutical composition for oral administration comprising fexofenadine and/or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier which is either polyethylene glycol or a propylene glycol-based solvent, or a mixture thereof, from 35 to 90% wt. of a pharmaceutical excipient stabilizing fexofenadine and/or a pharmaceutically acceptable salt thereof, said pharmaceutical excipient consisting of glycerol with optionally sorbitol. The invention also relates to the uses of these compositions as a medicament and to the process for preparing said compositions.

摘要翻译： 本发明涉及用于口服给药的液体药物组合物，其包含非索非那定和/或其药学上可接受的盐，药学上可接受的载体，其为聚乙二醇或丙二醇基溶剂，或其混合物，其为35至90％ 重量。 药物赋形剂稳定非索非那定和/或其药学上可接受的盐，所述药物赋形剂由甘油和任选的山梨糖醇组成。 本发明还涉及这些组合物作为药物和制备所述组合物的方法的用途。

公开(公告)号：EP2870156A1

公开(公告)日：2015-05-13

申请号：EP13733248.2

申请日：2013-06-21

申请人： SANOFI

发明人： EL-AHMAD, Youssef ,  FILOCHE-ROMME, Bruno ,  GANZHORM, Axel ,  MARCINIAK, Gilbert ,  MUZET, Nicolas ,  RONAN, Baptiste ,  VIVET, Bertrand ,  ZERR, Véronique

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P33/00

CPC分类号： C07D519/00 ,  A61K31/519 ,  A61K31/5386 ,  C07D487/04 ,  C09D11/106 ,  C09D11/108 ,  C09D11/322 ,  C09D11/324 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423

摘要： The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

摘要翻译： 本发明涉及具有通式（I）的新型嘧啶酮基杂环化合物，其为具有通式（I）的寄生虫生长抑制剂，其中Y是选自三个桥连吗啉的吗啉，L是键或连接基，n = 0或1，R 当n = 0时，2为甲基，n = 1时为氢原子。其制备方法及其治疗用途。

公开(公告)号：EP2797917A1

公开(公告)日：2014-11-05

申请号：EP12824734.3

申请日：2012-12-26

申请人： SANOFI

发明人： CLARY-CECCATO, Marie-Line ,  GUILLO, Nathalie

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P3/00 ,  A61P9/00 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  C07D401/14 ,  C07D519/00

摘要： The invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives that induce fibroblast growth factor receptor (FGFR) dimerization, having the general formula: M
1 -L-M
2 in which M
1 or M
2 , which may be identical or different, each represent, independently of one another, a monomer unit M and L represents a linker group which links M
1 and M
2 covalently with the monomer unit which follows: Process for the preparation thereof and therapeutic use thereof.

公开(公告)号：EP2521725A1

公开(公告)日：2012-11-14

申请号：EP11704257.2

申请日：2011-01-06

申请人： SANOFI

发明人： BELLEVERGUE, Patrice ,  GRAILHE, Patrick ,  MCCORT, Gary ,  O'CONNOR, Stephen ,  DUCLOS, Olivier

IPC分类号： C07D471/04 ,  C07C311/21 ,  C07F5/02 ,  A61P9/00 ,  A61K31/519

CPC分类号： C07D471/04 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/5377 ,  A61K45/06 ,  C07F5/025

摘要： The invention relates to pyridine-pyridinone derivatives of general formula (I), where R1, R2, R3, R4, n, n', V, W, Y, Z and Ar are as defined in the description, as well as to methods for preparing the same and to the therapeutic uses thereof.

公开(公告)号：EP3185855A1

公开(公告)日：2017-07-05

申请号：EP15739632.6

申请日：2015-07-23

申请人： Boehringer Ingelheim International GmbH ,  Sanofi-Aventis de Mexico SA de CV ,  Sanofi-Aventis Deutschland GmbH

发明人： SAUERLAND, Sandra ,  FUERST, Thomas ,  HEGEWISCH, Alberto ,  WEISER, Thomas

IPC分类号： A61K9/20 ,  A61P29/00

CPC分类号： A61K47/38 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/192 ,  A61K31/522 ,  A61K2300/00

摘要： The invention relates to a film coated tablet for the treatment of acute pain containing 400 mg of ibuprofen, 100 mg of caffeine, 50 to 100 mg of one or more disintegrating agents and to a process for the preparation of the film coated tablet according to the invention.

摘要翻译： 本发明涉及一种用于治疗急性疼痛的薄膜包衣片剂，其包含400mg布洛芬，100mg咖啡因，50至100mg一种或多种崩解剂以及制备根据 发明。

公开(公告)号：EP3027176A1

公开(公告)日：2016-06-08

申请号：EP14753025.7

申请日：2014-07-25

申请人： SANOFI

发明人： BRENNE, Jean-François ,  CALLIGARIS, Frédérique ,  DASTE, Georges ,  EDELINE-BERLEMONT, Julie ,  FONTAINE, Nicolas

IPC分类号： A61K9/20 ,  A61K31/435 ,  A61K31/60 ,  A61K31/621

CPC分类号： A61K31/60 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2886 ,  A61K31/4365 ,  A61K2300/00

摘要： The present invention relates to a tablet comprising a core and an external layer, the core comprising acetylsalicylic acid or a pharmaceutically acceptable salt thereof and the external layer comprising clopidogrel or a pharmaceutically acceptable salt thereof, the core being separated from the external layer by a three-layer coating composed of a gastro-resistant layer inserted between two isolating layers.

摘要翻译： 本发明涉及包含核心和外层的片剂，所述核心包含乙酰水杨酸或其药学上可接受的盐之一，外层包含氯吡格雷或其药学上可接受的盐之一，所述核与外部分离 通过由两层绝缘层之间插入的耐胃层组成的三层涂层。

公开(公告)号：EP2956011A1

公开(公告)日：2015-12-23

申请号：EP14703892.1

申请日：2014-02-12

申请人： SANOFI

发明人： DASTE, Georges ,  DEROUET, Benjamin ,  RENOUARD, Marie

IPC分类号： A23G3/36 ,  A23G3/48 ,  A61K9/00 ,  A61K9/20 ,  A61K31/445

CPC分类号： A61K9/0056 ,  A23G3/364 ,  A23G3/48 ,  A23L29/231 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/192 ,  A61K31/445 ,  A61K31/47 ,  A61K47/10 ,  A61K47/36

摘要： The present invention relates to chewable compositions for oral administration, said compositions comprising high(methyl)pectin, glycerol and water. Advantageously, the chewable composition can comprise a drug substance. The present invention also concerns a process for preparing the chewable composition and the use of said chewable composition as a medicament.

公开(公告)号：EP2800566A1

公开(公告)日：2014-11-12

申请号：EP13702101.0

申请日：2013-01-03

申请人： SANOFI

发明人： ALCOUFFE, Chantal ,  HERBERT, Corentin

IPC分类号： A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/437

摘要： The invention relates to the use of compounds corresponding to formula (I) in which R
2 and R
3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of the formulae (A), (B) and (C) in which the wavy lines represent the phenyl nucleus to which R
2 and R
3 are attached, or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.

公开(公告)号：EP2668198A1

公开(公告)日：2013-12-04

申请号：EP12703584.8

申请日：2012-01-27

申请人： SANOFI

发明人： DRIGUEZ, Pierre Alexandre ,  DUCHAUSSOY, Philippe ,  FONS, Pierre

IPC分类号： C07H15/04 ,  C08B37/00 ,  A61K31/737 ,  A61P17/02

CPC分类号： C07H13/12 ,  A61K31/737 ,  C07H15/04 ,  C08B37/006 ,  C08B37/0075

摘要： The invention relates to the FGF receptor-activating oligosaccharides corresponding to formula (I) in which R1 represents an optionally substituted -O-alkyl group, R2 represents a hydroxyl group or an -O-alkyl group, R3, R5, R6, R7 and R8 represent -OSO3- or hydroxyl groups, R4 represents an NH-CO-alkyl or -O-alkyl group, R represents an -O-alkyl group, and n and m, which may be identical to or different from one another, represent integers equal to 0 or 1. Method for the preparation thereof and therapeutic use thereof.