利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

927 条记录 (耗时 0.036 秒)

    AGENTS FOR REDUCING THE ACTIVITY OF GDF15
    1.
    发明公开
    AGENTS FOR REDUCING THE ACTIVITY OF GDF15 审中-公开

    公开(公告)号：EP3325508A1

    公开(公告)日：2018-05-30

    申请号：EP16741628.8

    申请日：2016-07-20

    申请人： Genagon Therapeutics AB

    发明人： BLOKZIJL, Olof Andries ,  FREDRIKSSON, Johan Erik Simon

    IPC分类号： C07K16/28 ,  C07K14/705

    CPC分类号： C07K16/22 ,  A61P35/04 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30

    摘要： The present invention relates to agents for reducing the activity of GDF15 and in particular the use of such agents to treat or prevent conditions associated with elevated or unwanted levels of GDF15. The invention is based on the discovery that GDF15 binds to the receptors CLPTM1 and QRFPR and provides agents for such use in the form of binding agents capable of binding to the receptors and inhibiting the interaction between GDF15 and the receptor. Further agents include polypeptides derived from the receptors which are capable of binding to GDF15 and inhibiting its interaction with the receptors. Also provided are diagnostic methods based on detecting the interaction or an effect thereof, and cytotoxic immune cells modified to have a reduced level and/or activity of CLPTM1.

    EXONUCLEASE ENABLED PROXIMITY EXTENSION ASSAYS
    2.
    发明公开
    EXONUCLEASE ENABLED PROXIMITY EXTENSION ASSAYS 审中-公开

    公开(公告)号：EP3323896A2

    公开(公告)日：2018-05-23

    申请号：EP17183834.5

    申请日：2012-01-30

    申请人： Olink Proteomics AB

    发明人： FREDRIKSSON, Simon ,  LUNDBERG, Martin ,  LARSSON, Anna ,  RENNEL-DICKENS, Emma

    IPC分类号： C12Q1/68 ,  G01N33/542 ,  G01N33/58

    摘要： The present invention relates to a proximity probe based detection assay ("proximity assay") for an analyte in a sample, specifically a proximity probe extension assay (PEA), an in particular to an improvement in the method to reduce non-specific "background" signals, wherein the improvement comprises the use in such assays of a component comprising 3' exonuclease activity, said method comprising: (a) contacting said sample with at least one set of at least first and second proximity probes, which probes each comprise an analyte-binding domain and a nucleic acid domain and can simultaneously bind to the analyte; (b) allowing the nucleic acid domains of the proximity probes to interact with each other upon binding of said proximity probes to said analyte, wherein said interaction comprises the formation of a duplex; (c) contacting said sample with a component comprising 3' exonuclease activity; (d) extending the 3' end of at least one nucleic acid domain of said duplex to generate an extension product, wherein the step may occur contemporaneously with or after step (c); and (e) amplifying and detecting the extension product.

    PREDICTING INCREASED RISK FOR CANCER
    4.
    发明授权
    PREDICTING INCREASED RISK FOR CANCER 有权
    预测癌症风险增加

    公开(公告)号：EP3055425B1

    公开(公告)日：2018-03-14

    申请号：EP14789193.1

    申请日：2014-10-07

    申请人： Cray Innovation AB

    发明人： FORSBERG, Lars ,  DUMANSKI, Jan

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q1/6879 ,  C12Q2600/118 ,  C12Q2600/156

    摘要： Male subjects having an increased risk of developing cancer are identified by determining a fraction of cells that have lost chromosome Y in a biological sample obtained from the male subject. The fraction is compared to a predefined threshold and the male subject is predicted to have an increased risk of developing cancer based on the comparison between the fraction and the predefined threshold.

    AQUEOUS PREPARATION FOR EXTERNAL USE
    6.
    发明公开
    AQUEOUS PREPARATION FOR EXTERNAL USE 审中-公开
    用于外用的水性制剂

    公开(公告)号：EP3251695A1

    公开(公告)日：2017-12-06

    申请号：EP16743599.9

    申请日：2016-01-29

    申请人： MEDRx Co., Ltd.

    发明人： YAMANAKA, Katsuhiro

    IPC分类号： A61K47/12 ,  A61K9/08 ,  A61K31/196 ,  A61K47/10 ,  A61K47/18 ,  A61P29/00

    CPC分类号： A61K9/08 ,  A61K9/0014 ,  A61K31/19 ,  A61K31/196 ,  A61K31/205 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18

    摘要： The purpose of the present invention is to provide an aqueous preparation for external use, said aqueous preparation comprising an acidic drug such as an arylacetic acid nonsteroidal anti-inflammatory analgesic, having an excellent percutaneous absorbability and giving a good feeling in use. The aqueous preparation for external use comprises the acidic drug or a salt thereof, isostearic acid and an alkanol amine. It is preferred that the aqueous preparation according to the present invention for external use further comprises a C 2-6 aliphatic hydroxy acid and has a pH value of 4.5-7.8. The C 2-6 aliphatic hydroxy acid is one member or a combination of the same selected from the group consisting of lactic acid, glycolic acid, malic acid, tartaric acid and citric acid.

    摘要翻译： 本发明的目的在于提供一种外用水性制剂，其含有酸性药物如芳基乙酸非甾族抗炎镇痛药，具有优异的经皮吸收性并且使用感良好。 外用水性制剂包含酸性药物或其盐，异硬脂酸和链烷醇胺。 优选的是，本发明的外用水性制剂还含有C 2-6脂肪族羟基酸，其pH值为4.5-7.8。 C 2-6脂肪族羟基酸是选自乳酸，乙醇酸，苹果酸，酒石酸和柠檬酸中的一种或其组合。