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公开(公告)号：EP0700438A1
公开(公告)日：1996-03-13
申请号：EP94920679.0
申请日：1994-05-20
发明人： BELL, Graeme, I. , REISINE, Terry , YASUDA, Kazuki
IPC分类号： G01N33 , A61K38 , A61K39 , A61P1 , A61P5 , A61P9 , A61P11 , A61P25 , A61P37 , A61P43 , C07H21 , C07K14 , C07K16 , C07K19 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , C12R1
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/033 , C07K2319/32
摘要： The invention relates generally to compositions of and methods for obtaining opioid receptor polypeptides. The invention relates as well to polynucleotides encoding opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different opioid receptor polypeptides. The invention includes as well methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
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公开(公告)号：EP0700438B1
公开(公告)日：2005-02-09
申请号：EP94920679.1
申请日：1994-05-20
发明人： BELL, Graeme, I. , REISINE, Terry , YASUDA, Kazuki
IPC分类号： C07K14/705 , C12N15/12 , C12N15/62 , C12N5/10 , G01N33/68 , C12Q1/68 , A61K38/17 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/033 , C07K2319/32
摘要： The invention relates generally to compositions of and methods for obtaining opioid receptor polypeptides. The invention relates as well to polynucleotides encoding opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different opioid receptor polypeptides. The invention includes as well methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
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3.发明公开MUTATIONS IN THE DIABETES SUSCEPTIBILITY GENES HEPATOCYTE NUCLEAR FACTOR (HNF) 1 ALPHA ($g(a)), HNF-1$g(b) AND HNF-4$g(a) 无效突变WITHIN糖尿病易感性基因肝细胞关键因子（HNF）HNF-1α，HNF-1β和HNF-4alpha
公开(公告)号：EP0920534A1
公开(公告)日：1999-06-09
申请号：EP97941508.0
申请日：1997-09-10
发明人： BELL, Graeme, I. , YAMAGATA, Kazuya Second Dept.of InternalMedicine , ODA, Naohisa , KAISAKI, Pamela, J. , FURUTA, Hiroto The First Department of Medicine , MENZEL, Stephan , HORIKAWA, Yukio
CPC分类号： C07K14/4702 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates generally to the fields diabetes. More particularly, it concerns the identification of genes responsible for NIDDM for use in diagnostics and therapeutics. The present invention demonstrates that the MODY3 locus is, in fact, the HNF-1α gene, MODY4 locus is the HN-F1β and the MODY1 locus is the HNF-4α gene. The invention further relates to the discovery that analysis of mutations in the HNF-1α, HNF-1β and HNF-4α genes can be diagnostic for diabetes. The invention also contemplates methods of treating diabetes in view of the fact that HNF-1α, HNF-1β and HNF-4α mutations can cause diabetes.
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4.发明授权MUTATIONS IN THE DIABETES SUSCEPTIBILITY GENES HEPATOCYTE NUCLEAR FACTOR (HNF) HNF-1ALPHA, HNF-1BETA AND HNF-4ALPHA 无效易感基因突变WITHIN肝细胞关键因子（HNF）HNF-1α，HNF-1β和HNF-4alpha糖尿病
公开(公告)号：EP0920534B1
公开(公告)日：2005-12-28
申请号：EP97941508.0
申请日：1997-09-10
发明人： BELL, Graeme, I. , YAMAGATA, Kazuya Second Dept.of InternalMedicine , ODA, Naohisa , KAISAKI, Pamela, J. , FURUTA, Hiroto The First Department of Medicine , MENZEL, Stephan , HORIKAWA, Yukio
CPC分类号： C07K14/4702 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
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公开(公告)号：EP0621874B1
公开(公告)日：2000-04-05
申请号：EP93902841.1
申请日：1992-12-30
CPC分类号： C07K14/723
摘要： The invention relates generally to compositions of and methods for obtaining somatostatin receptors. The invention relates as well to the DNA sequences encoding somatostatin receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant somatostatin receptor polypeptides. By way of example, the invention discloses th cloning and functional expression of at least three different somatostatin receptors, SSTR1, SSTR2 and SSTR3 from two different mammalian sources. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with somatostatin receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
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公开(公告)号：EP0621874A1
公开(公告)日：1994-11-02
申请号：EP93902841.0
申请日：1992-12-30
CPC分类号： C07K14/723
摘要： L'invention concerne d'une manière générale des compositions et des procédés permettant d'obtenir des récepteurs de somotostatine. L'invention concerne également des séquences d'ADN codant des récepteurs de somotostatine, les vecteurs de recombinaison portant ces séquences, les cellules hôtes de recombinaison comprenant soit les séquences soit les vecteurs, et des polypeptides de récepteurs de somotostatine de recombinaison. A titre d'exemple, l'invention concerne le clonage et l'expression fonctionnelle d'au moins trois récepteurs différents de somotostatine, SSTR1, SSTR2 et SSTR3 à partir de deux sources mammifères différentes. L'invention comprend également des procédés d'utilisation des polypeptides de récepteurs de recombinaison dans des dosages destinés à sélectionner et améliorer des substances capables d'avoir une interaction avec des polypeptides de récepteurs de somotostatine à des fins diagnostiques, de mise au point de médicaments et à des applications thérapeutiques.
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