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28 条记录 (耗时 0.018 秒)

    COATED IMPLANTS
    2.
    发明公开
    COATED IMPLANTS 有权
    包被的植入

    公开(公告)号：EP1250164A1

    公开(公告)日：2002-10-23

    申请号：EP01942570.1

    申请日：2001-01-24

    申请人： Biocompatibles Ltd.

    发明人： HUGHES, Laurence, Gerald ,  VICK, Terrence Albert ,  WANG, Jin Hai

    IPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/04 ,  A61L31/16

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/043 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/606 ,  Y10T428/31855 ,  C08L101/02

    摘要： An implant, usually a stent, has a coating of a cross-linked water swellable polymer matrix preferably having a dry thickness of at least 0.1 νm, and a pharmaceutically active compound, the polymer having pendant cationic and pendant zwitterionic groups. The active is usually an anionic compound such as a nucleic acid. The polymer is peferably formed from 2-methacyloyloxyethyl-2'-trimethylammoniumethyl phosphate inner salt, trialkylammoniumalkyl(meth)acrylate and a cross-linkable monomer such as φ-(trialkoxysilyl)alkyl(meth)acrylate, optionally with a termonomer such as a higher alkyl (meth)acrylate. The stent is coated with polymer, cross-linked then contacted with a solution or dispersion of active compound in a solvent which swells the polymer wehereby the active is absorbed into the polymer matrix. The stent is delivered by usual means into a body lumen and the active is released over an extended period of time into the wall of the lumen and/or fluid flowing therein.

    AEROSOL
    4.
    发明公开
    AEROSOL 失效
    气雾剂。

    公开(公告)号：EP0240511A1

    公开(公告)日：1987-10-14

    申请号：EP86905370.0

    申请日：1986-09-17

    申请人： BIOCOMPATIBLES LTD.

    发明人： HAYWARD, James, Arthur

    IPC分类号： A61K9

    CPC分类号： A61K9/0078 ,  A61K9/127

    摘要： Aérosol comprenant un fluide porteur et des liposomes en suspension dans ledit fluide et contenant un phospholipide, un agent thérapeutique ou diagnostique destinés à être inhalés étant enfermés dans lesdits liposomes.

    SILICON CONTAINING COMPOUNDS FROM MICHAEL - TYPE ADDITION REACTIONS USEFUL AS MONOMERS AND MACROMERS
    5.
    发明公开
    SILICON CONTAINING COMPOUNDS FROM MICHAEL - TYPE ADDITION REACTIONS USEFUL AS MONOMERS AND MACROMERS 有权
    获得由Michael加成反应AS式的单体和大分子单体硅含氧化合物

    公开(公告)号：EP1255761A1

    公开(公告)日：2002-11-13

    申请号：EP01905867.6

    申请日：2001-02-07

    申请人： Biocompatibles Ltd.

    发明人： LEWIS, Andrew Lennard,Biocompatibles Limited ,  COLLIAS, Anthony Claude Marie,Biocompatibles Ltd ,  REDMAN, Richard Paul,Biocompatibles Limited ,  COURT, Jane Louise,Biocompatibles Limited ,  WILLIS, Sean Leo,Biocompatibles Limited

    IPC分类号： C07F7/08 ,  C08G77/04 ,  C08G77/00 ,  C08G77/26 ,  C08G77/388 ,  C07F9/09 ,  C07F9/22 ,  C07F7/02 ,  C08L83/08

    CPC分类号： C08L83/08 ,  C07F7/0854 ,  C07F9/091 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  Y10T428/1457 ,  Y10T428/249969 ,  Y10T428/31663

    摘要： A silicon containing adduct having the formula (I) wherein X is an electron withdrawing group selected from the group consisting of carbonyl and sulphone groups, sulphonium and phosphonium salts; R is selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, alkaryl, aralkyl, alkoxyaryl, alkoxyalkyl, oligoalkoxyalkyl, di-alkylaminoalkyl, N-aryl-N-alkylaminoalkyl, hydroxyalkoxy, alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, cycloalkenyloxy, cycloalkynyloxy, aralkoxy, alkoxyaryloxy, alkoxyalkoxy, oligoalkoxyalkoxy, di-alkylaminoalkoxy, N-aryl-N-alkylamino-alkoxy, acyloxy, acyloxyalkyl, N-diacyl-iminoalkyl groups, organosilane, organosiloxane, hydroxyaryl, hydroxyalkenyl, hydroxyalkynyl and hydroxy groups and any of the above groups substituted with one or more hydroxyl or zwitterionic group Z, or R-X- is a nitrile group; R?3 and R4¿ are individually selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl, and alkynyl groups, aryl, alkoxycarbonyl, alkylaminocarbonyl, cycloalkyl, cycloalkenyl, cycloalkynyl, haloaryl, haloalkyl, alkaryl, aralkyl, alkoxyaryl, alkoxyalkyl, oligoalkoxyalkyl, aminoalkyl, mono- and di-alkylaminoalkyl, arylaminoalkyl, N-aryl-N-alkylaminoalkyl and -aminoaryl, acyloxy, acyloxyalkyl, acylaminoalkyl, N-diacyl-iminoalkyl groups, alkylaminocarbonyl, oxacycloalkyl, oxacycloalkenyl, organosilane and organosiloxane groups and any of the above groups substituted with a zwitterionic group Z, a hydroxyl group or an isocyanate group; R?1 and R2¿ are individually selected from hydrogen and C¿1?-C12 alkyl groups; and at least one of groups R, R?3, and R4¿ contain an organosiloxane group Y and/or an organosilane group U. The invention additionally provides processes for the production of such an adduct, polymers formed therefrom, coating processes and compositions comprising an adduct or polymers produced therefrom.