公开(公告)号：EP1165560A1

公开(公告)日：2002-01-02

申请号：EP00913872.8

申请日：2000-03-10

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： ZEMLICKA, Jiri ,  QIU, Yao-Ling ,  DRACH, John, C. ,  PTAK, Roger, G.

IPC分类号： C07D473/16 ,  C07D473/18 ,  A61K31/52 ,  A61K31/522

CPC分类号： C07D239/47 ,  C07D239/54 ,  C07D473/00 ,  C07D473/16 ,  C07D473/18 ,  C07D473/34 ,  C07F9/65061 ,  C07F9/65616

摘要： Compounds which are active against viruses have Formulas (1, 2, 3 and 4) wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of 6-aminopurine (adenine), 2,6-diaminopurine, 2-amino-6-azidopurine, 2-amino-6-cyclopropylaminopurine, 6-hydroxypurine (hypoxanthine), 2-amino-6-halo substituted purines, 2-amino-6-alkoxy substituted purines, 2-amino-6-hydroxypurine (guanine), 3-deazapurines, 7-deaza-purines, 8-azapurines, cytosine, 5-halo substituted cytosines, 5-alkyl substituted cytosines, thymine, uracil and 6-azapyrimidines; X is O; and, R1 and R2 are alkyl or aryl groups. The compounds of the present invention also include the R- and S-enantiomers of the above compounds. The R1X and/or R2X can also be amino acid residues with X as NH.

摘要翻译： 对病毒具有活性的化合物具有式（1,2,3和4），其中B是嘌呤或嘧啶杂环并且优选选自6-氨基嘌呤（腺嘌呤），2,6-二氨基嘌呤，2-氨基嘌呤， 氨基-6-叠氮基嘌呤，2-氨基-6-环丙基氨基嘌呤，6-羟基嘌呤（次黄嘌呤），2-氨基-6-卤代嘌呤，2-氨基-6-烷氧基取代的嘌呤，2-氨基-6-羟基嘌呤（鸟嘌呤 ），3-脱氮嘌呤，7-脱氮嘌呤，8-氮杂嘌呤，胞嘧啶，5-卤代取代的胞嘧啶，5-烷基取代的胞嘧啶，胸腺嘧啶，尿嘧啶和6-氮杂嘧啶; X是O; 并且，R1和R2是烷基或芳基。 本发明的化合物还包括上述化合物的R-和S-对映体。 R1X和/或R2X也可以是X为NH的氨基酸残基。

公开(公告)号：EP0603305B1

公开(公告)日：1997-05-14

申请号：EP92919977.6

申请日：1992-09-08

申请人： ALPHA 1 BIOMEDICALS, INC. ,  THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA as represented by the Secretary of the Army

发明人： MUTCHNICK, Milton ,  CHRETIAN, Paul ,  SHERMAN, Kenneth E.

IPC分类号： A61K38/16

CPC分类号： A61K38/2292 ,  Y10S514/885 ,  Y10S514/894

摘要： Compositions and methods of use for treating hepatitis C virus-infected mammals are disclosed. The compositions include one or more thymosins alone or in combination with one or more interferons. Methods of treatment include use of thymosins alone, or together, or sequentially with interferon.

公开(公告)号：EP0757052A1

公开(公告)日：1997-02-05

申请号：EP96112386.6

申请日：1996-07-31

申请人： BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY ,  LUMIGEN, INC.

发明人： Akhavan-Tafti, Hashem ,  De Silva, Renuka ,  Schaap, Paul A.

IPC分类号： C07F9/655 ,  G01N33/533 ,  C07D321/00 ,  C07F9/12 ,  C07C69/708

CPC分类号： G01N33/582 ,  C07C69/00 ,  C07C2603/00 ,  C07D321/00 ,  C07F9/12 ,  C07F9/65512 ,  G01N33/5308 ,  G01N33/54326

摘要： Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility are provided. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. Compositions comprising a dioxetane with two or more water-solubilizing groups, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

公开(公告)号：EP0254051B1

公开(公告)日：1994-08-31

申请号：EP87108978.5

申请日：1987-06-23

申请人： THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： Schaap, Arthur P.

IPC分类号： C07D321/00 ,  C07D493/10 ,  C07F7/18 ,  C07F9/12 ,  C09K11/00

CPC分类号： C07D405/12 ,  C07C37/00 ,  C07C37/055 ,  C07C37/62 ,  C07C51/15 ,  C07C2603/18 ,  C07C2603/74 ,  C07D207/46 ,  C07D311/82 ,  C07D321/00 ,  C07D407/10 ,  C07D407/12 ,  C07D417/12 ,  C07D493/10 ,  C07D495/04 ,  C07F7/1852 ,  C07F7/1856 ,  C07F9/6541 ,  C07F9/65512 ,  C07F9/65522 ,  C07F9/65586 ,  C07F9/6561 ,  C07H15/203 ,  C07C65/11 ,  C07C39/38 ,  C07C39/23

公开(公告)号：EP1325922B1

公开(公告)日：2005-08-03

申请号：EP03005154.4

申请日：1995-11-03

申请人： Indiana University Research and Technology Corporation ,  PURDUE RESEARCH FOUNDATION ,  THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： Grieco, Paul A ,  Morre, D. James ,  Corbett, Thomas H. ,  Valeriote, Frederick A.

IPC分类号： A61K31/35 ,  A61K31/365 ,  A01N43/16 ,  C07D493/10

CPC分类号： C07D493/10 ,  A01N43/90 ,  A01N65/08 ,  A61K31/366

公开(公告)号：EP0731710B1

公开(公告)日：2003-05-14

申请号：EP94901265.2

申请日：1993-11-05

申请人： ALPHA 1 BIOMEDICALS, INC. ,  THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： CHRETIEN, Paul B. ,  MUTCHNICK, Milton G.

IPC分类号： A61K38/22 ,  A61P31/12 ,  A61P43/00

CPC分类号： A61K38/2292

摘要： A method and composition for treating a Hepatitis B patient having hepatic decompensation utilizes Hepatitis B virus-reducing amounts of T alpha 1, administered to a patient having decompensated liver disease so as to render the patient seronegative for Hepatitis B virus DNA.

公开(公告)号：EP0687181B1

公开(公告)日：2001-08-29

申请号：EP94910226.3

申请日：1994-03-03

申请人： ALPHA 1 BIOMEDICALS, INC. ,  THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： CHRETIEN, Paul B. ,  MUTCHNICK, Milton

IPC分类号： A61K38/16

CPC分类号： A61K38/2292

摘要： A method of treating Hepatitis C by administering an immune system-potentiating dose of at least one Thymosin or system-potentiating Thymosin fragment to a mammal infected with Hepatitis C virus, which Hepatitis C infection in the mammal is non-responsive to treatment with interferon alone.

公开(公告)号：EP0473984A1

公开(公告)日：1992-03-11

申请号：EP91113601.8

申请日：1991-08-13

申请人： THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： Schaap, Arthur Paul ,  Romano, Louise J. ,  Goudar, Jaidev S.

IPC分类号： C07D321/00 ,  C07F7/18 ,  C07D495/04 ,  C07D405/12 ,  C07D407/12 ,  C07D311/82 ,  C07D207/46 ,  C07C217/10 ,  C07C59/66 ,  G01N33/533 ,  C09K11/07

CPC分类号： C07D405/12 ,  C07D207/46 ,  C07D321/00 ,  C07D407/12 ,  C07D495/04 ,  C07F7/1852 ,  C07F7/1856 ,  C09K11/07 ,  G01N33/533

摘要： Dioxetanes which couple with organic and biological molecules of the formula:

wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R₁ is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.

摘要翻译： 与下式的有机和生物分子偶联的二氧杂环丁烷：其中X是通过活化剂除去以产生光的离去基团，其中A是偶联取代基，Ar是选自苯基 和萘基以提供标记。 R1是任选的接头取代基并且可以具有1至30个碳原子，其中一些碳原子是氧，硫，氮或磷。 Ar是苯基。 二氧杂环丁烷偶联分子可用于所有类型的测定，其中发光可用作指示剂。

公开(公告)号：EP0417924A1

公开(公告)日：1991-03-20

申请号：EP90309241.9

申请日：1990-08-23

申请人： BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： Pryor, Roger W.

IPC分类号： C01B31/06 ,  C30B29/04

CPC分类号： C23C16/274 ,  C01B32/25 ,  C23C16/01 ,  C30B25/02 ,  C30B29/04 ,  Y10S117/90

摘要： Shaped synthetic diamond articles are fabricated by vapour deposition of synthetic diamond on releasable moulds. A process is also provided for forming a shaped synthetic diamond article by coating a mould with an etchable layer and then depositing synthetic diamond on the etchable layer; the etchable layer is thereafter removed in an etchant bath, releasing the diamond article from the mould. The synthetic diamond articles are useful as high-­temperature, corrosion resistant vessels and as wear surfaces.

摘要翻译： 合成金刚石制品通过将合成金刚石气相沉积在可剥离模具上制造。 还提供了一种通过用可蚀刻层涂覆模具然后将合成金刚石沉积在可蚀刻层上来形成成形合成金刚石制品的方法; 然后在蚀刻剂浴中除去可蚀刻层，将金刚石制品从模具中释放出来。 合成金刚石制品可用作耐高温，耐腐蚀的容器和磨损表面。

公开(公告)号：EP0123850A3

公开(公告)日：1989-04-26

申请号：EP84102861.6

申请日：1984-03-15

申请人： THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

发明人： Taylor, John D. ,  Honn, Kenneth V.

IPC分类号： A61K31/445 ,  A61K31/275 ,  A61K31/55

CPC分类号： A61K31/275 ,  A61K31/44 ,  A61K31/55

摘要： The use of calcium channel blocker compounds as antitumor and antimetastatic agents in mammals in vivo and in standard laboratory experiments with tumor cells in vitro is described. In particular the use of nimodipine (Bay e 9736) or nifedipine (Bay a 1040) and structurally related compounds as described.