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    Gene coding for a polypeptide which enhances virus infection of host insects
    2.
    发明公开
    Gene coding for a polypeptide which enhances virus infection of host insects 失效
    编码这增加寄主昆虫的病毒感染的多肽的基因。

    公开(公告)号：EP0596508A1

    公开(公告)日：1994-05-11

    申请号：EP93117929.5

    申请日：1993-11-04

    申请人： BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC.

    发明人： Granados, Robert R. ,  Hashimoto, Yoshifumi, Dept.of Applied Biology

    IPC分类号： C07K15/00 ,  C12N15/34 ,  A01N63/00

    CPC分类号： C07K14/005 ,  A01N63/02 ,  C12N15/86 ,  C12N2710/14121 ,  C12N2710/14122 ,  C12N2710/14143 ,  Y10S530/826

    摘要： Isolated and cloned baculovirus genes encoding a polypeptide protein present in the occlusion body of certain baculoviruses such as Trichoplusia ni granulosis virus and Pseudaletia unipuncta granulosis virus Hawaiian strain, said genes possessing a biological activity of enhancing virus infection of host insects by causing rapid degradation of the peritrophic membrane lining the midgut lumen of insects. The invention is also directed to pesticides incorporating said genes, i.e. the purified conserved and enhancing baculovirus proteins herein termed enhancins.

    摘要翻译： 编码本中的某些杆状病毒的闭塞体的多肽的蛋白质分离的和克隆的杆状病毒基因：如粉纹夜蛾颗粒体病毒和粘虫unipuncta颗粒体病毒夏威夷菌株，所述基因波塞通过使迅速降解唱寄主昆虫的增强病毒感染的生物活性 食膜衬昆虫中肠流明。 因此，本发明涉及杀虫剂掺入所述基因，即 将纯化的保守的，并且在称之enhancins提高杆状病毒蛋白。

    DNA SEQUENCE CODING FOR A POLYPEPTIDE WHICH ENHANCES VIRUS INFECTION OF HOST INSECTS
    4.
    发明公开
    DNA SEQUENCE CODING FOR A POLYPEPTIDE WHICH ENHANCES VIRUS INFECTION OF HOST INSECTS 失效
    DNA序列编码的宿主昆虫增强多肽的病毒感染

    公开(公告)号：EP0847401A1

    公开(公告)日：1998-06-17

    申请号：EP96932934.0

    申请日：1996-08-23

    申请人： BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC.

    发明人： GRANADOS, Robert, R.

    IPC分类号： C12N15 ,  A01N63 ,  C07K14 ,  C12N7 ,  A61K38 ,  C12R1

    CPC分类号： C07K14/005 ,  A01N63/02 ,  A61K38/00 ,  C12N2710/14143 ,  C12N2750/12022 ,  Y10S530/825 ,  Y10S530/826

    摘要： This disclosure relates to an isolated and cloned DNA from a granulovirus virus which comprises an amino acid sequence of the viral gene encoding a polypeptide isolated from occlusion bodies of certain baculoviruses and which polypeptide possesses the biological activity of enhancing baculovirus infectivity. Such proteins termed herein as 'enhancins' are found within the viral occlusion body, have a disruptive effect on the insect peritrophic membrane (PM) proteins, and/or interact with the midgut epithelium in such a manner as to permit the increased adsorption, penetration and uptake of virus particles by midgut cells with a concomitant increase in host mortality. Disclosed herein is a recombinant DNA sequence which codes for the enhancin protein of the Helicoverpa armigera granulovirus virus. The DNA sequence is shown in SEQ. ID. NO. :1 and the open reading frame is shown in SEQ. ID. NO.: 1: base pairs 271-2976. The amino acid sequence of the enhancin protein is shown in SEQ. ID. NO.: 2.

    GENETIC ENGINEERING IN PROCARYOTIC ORGANISM
    6.
    发明公开
    GENETIC ENGINEERING IN PROCARYOTIC ORGANISM 失效
    遗传转化原核生物。

    公开(公告)号：EP0113781A1

    公开(公告)日：1984-07-25

    申请号：EP83902654.0

    申请日：1983-07-06

    申请人： BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC.

    发明人： SZALAY, Aladar, A. ,  WILLIAMS, John, G., K.

    IPC分类号： C12N15 ,  C12N1

    CPC分类号： C12N15/90 ,  C12N15/63

    摘要： Micro-organisme procaryotique et son procédé de production, le micro-organisme contenant au moins une partie d'ADN stable dans le chromosome. Les micro-organismes ci-décrits ainsi que leurs descendants sont exempts de restructuration génétique comprenant l'ADN étranger. Dans un mode préférentiel de réalisation on utilise des cyanobactéries. Les micro-organismes sont produits en introduisant dans la cellule un véhicule d'insertion contenant de l'ADN étranger lié entre deux parties d'ADN homologues à des parties adjacentes du chromosome du récepteur.

    Oral immunology using plant product containing hepatitis surface antigen
    9.
    发明公开
    Oral immunology using plant product containing hepatitis surface antigen 审中-公开
    Orlor Impfung mir in Pflanzen produzierten nicht-enterische Pathogenantigene

    公开(公告)号：EP1093820A2

    公开(公告)日：2001-04-25

    申请号：EP00121916.1

    申请日：2000-10-07

    申请人： HEALTH RESEARCH, INC. ,  BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC.

    发明人： Thanavala, Yasmin ,  Arntzen, Charles J.

    IPC分类号： A61K39/29

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/5156 ,  A61K2039/542 ,  A61K2039/55544 ,  C12N15/8258 ,  C12N2730/10122 ,  C12N2730/10134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/40 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/472 ,  Y10S514/894

    摘要： A method for obtaining an immune response to hepatitis B surface antigen (HBsAG) by feeding the antigen in a plant material to an animal that is immunoreceptive to the HBsAg. It has now been discovered that the animal may be made immunoreceptive to HBsAg either by administering the plant material containing HBsAg in conjunction with a suitable adjuvant or by prior primary immunization. When the animal is made immunoreceptive by a prior, e.g. primary, immunization, an immune response to HBsAg may be boosted in the animal by feeding the animal the plant material containing the HBsAg. For example, an animal, e.g. a human, that previously had a positive response to primary immunization against hepatitis B, can have a booster response to HBsAg by feeding the animal the antigen in a plant material. The plant material is a substance comprising a physiologically acceptable plant material, especially potatoes, containing hepatitis B surface antigen (HBsAg). The HBsAg in the plant results from expression by the plant of HBsAg due to genetic alteration.

    摘要翻译： 通过将植物材料中的抗原喂养到对HBsAg免疫接受的动物来获得对乙型肝炎表面抗原（HBsAG）的免疫应答的方法。 现在已经发现，通过将含有HBsAg的植物材料与合适的佐剂联合或通过先前的初次免疫，可以使动物对HBsAg免疫接种。 当动物由先前的，例如， 原发性，免疫，对HBsAg的免疫应答可以通过向动物喂养含有HBsAg的植物材料来增强动物的免疫应答。 例如，动物，例如， 以前对乙型肝炎的初次免疫有正面反应的人可以通过将动物的抗原喂养在植物材料中而对HBsAg具有加强反应。 植物材料是包含生理上可接受的植物材料，特别是含有乙型肝炎表面抗原（HBsAg）的马铃薯的物质。 植物中的HBsAg由于遗传改变而由HBsAg植物表达。