公开(公告)号：EP2449130B1

公开(公告)日：2020-09-09

申请号：EP10794689.9

申请日：2010-06-30

申请人： Biomerieux, Inc

发明人： LOVERN, Douglas

IPC分类号： C12N1/20 ,  C12N1/38 ,  C12Q1/04

公开(公告)号：EP3612814A1

公开(公告)日：2020-02-26

申请号：EP18723240.0

申请日：2018-04-20

申请人： Biomerieux, Inc

发明人： HOFFMANN, JR., Jack R. ,  MAES, Gregory R.

IPC分类号： G01N21/47 ,  G01N21/51

公开(公告)号：EP2430457B1

公开(公告)日：2019-11-20

申请号：EP10720099.0

申请日：2010-05-14

申请人： Biomerieux, Inc

发明人： REMES, Richard, Scott ,  PHILIPAK, Stanley, Michael ,  FANNING, Mark, Joseph ,  ROBINSON, Ronnie, J. ,  BISHOP, James, Clement ,  GUERRA, Lawrence ,  SCHERER, Andrew ,  VALENTINO, Anthony ,  AMMERMAN, Mike ,  BERGOLD, Ron

IPC分类号： C12M1/34 ,  C12Q1/02 ,  C12Q1/04

公开(公告)号：EP2364447B1

公开(公告)日：2019-06-12

申请号：EP09760033.2

申请日：2009-10-30

申请人： Biomerieux, Inc

发明人： WALSH, John ,  HYMAN, Jones ,  THORPE, Thurman ,  CLAY, Bradford

IPC分类号： G01N33/68 ,  C12M1/34 ,  C12Q1/04 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65 ,  G01N21/359

公开(公告)号：EP3434759A1

公开(公告)日：2019-01-30

申请号：EP18180502.9

申请日：2012-07-20

申请人： bioMerieux, Inc.

发明人： HYMAN, Jones ,  ROBINSON, Ronnie ,  RONSICK, Christopher ,  WALSH, John

IPC分类号： C12M1/12 ,  C12N1/02 ,  C12N1/06 ,  C12Q1/24

摘要： The present invention is directed to methods and kits for separating, accumulating, characterizing and/or identifying microorganisms known to be present or that may be present in a test sample. The method of the invention comprises optional lysing non-microorganism cells and/or particulates that may be present in a test sample, followed by a subsequent filtration step for isolation and/or accumulation of microorganisms. The kit of the present invention may comprise at least one filter membrane or an integrated filtration and sample transfer device for isolation and/or accumulation of microorganisms.

公开(公告)号：EP2430459B1

公开(公告)日：2018-07-11

申请号：EP10726713.0

申请日：2010-05-14

申请人： Biomerieux, Inc

发明人： ROBINSON, Ronnie J. ,  FANNING, Mark Joseph ,  PHILIPAK, Stanley, Michael ,  REMES, Richard, Scott ,  BISHOP, James Clement ,  SOMMER, Gary ,  GUERRA, Lawrence ,  HERRON, Michae A. ,  AMMERMAN, Mike ,  BERGOLD, Ron ,  SCHERER, Andrew ,  VALENTINO, Anthony

IPC分类号： C12M1/34 ,  C12Q1/02 ,  C12Q1/04 ,  G01N35/00 ,  G01N35/04

CPC分类号： C12Q1/04 ,  C12M41/36 ,  C12Q1/02 ,  G01N35/00603 ,  G01N35/0099 ,  G01N35/026 ,  G01N2035/00148 ,  G01N2035/0406 ,  G01N2035/0453 ,  G01N2035/0465

摘要： A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.

公开(公告)号：EP1678506B1

公开(公告)日：2018-02-28

申请号：EP04781140.1

申请日：2004-08-13

申请人： bioMerieux, Inc.

发明人： BISHOP, James, Clement ,  JUSTIN, Michael, James ,  FANNING, Mark, Joseph

IPC分类号： G01N35/04 ,  G01N35/00 ,  G01N35/02 ,  G01N1/00

CPC分类号： G01N35/00029 ,  G01N2035/00148 ,  G01N2035/0465 ,  Y10T156/1313 ,  Y10T436/115831 ,  Y10T436/12

摘要： A sealer for a sample testing instrument is disclosed that cuts and seals a fluid conduit that connects a test sample device with a fluid receptacle containing a fluid sample. The sealer includes an enclosure and a protective shield to protect a user or technician from contact with the cutting element assembly in the sealer. The cutting element assembly includes a spring-loaded element that engages the test sample device and holds it in a fixed position while a cutting element (e.g., hot wire) cuts the fluid conduit. A motor driving the cutting element assembly is positioned at an angle having both vertical and horizontal components, whereby adjustment of the motor firmware allows for adjustment of the position of the cutting element relative to the instrument in both horizontal and vertical directions.

公开(公告)号：EP2361377B1

公开(公告)日：2018-01-31

申请号：EP09748866.2

申请日：2009-10-30

申请人： Biomerieux, Inc

发明人： CLAY, Bradford ,  HYMAN, Jones ,  WALSH, John ,  THORPE, Thurman ,  RONSICK, Christopher

IPC分类号： G01N21/65 ,  C12M1/12 ,  C12M1/34 ,  G01N21/35 ,  G01N33/68 ,  G01N21/64 ,  G01N21/47 ,  G01N21/359 ,  G01N21/3581 ,  C12Q1/04

CPC分类号： C12Q1/04 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65 ,  G01N33/6848

摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for Raman spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said Raman spectroscopic measurements.

公开(公告)号：EP2702407A2

公开(公告)日：2014-03-05

申请号：EP12722687.6

申请日：2012-04-20

申请人： Biomerieux, Inc

发明人： CHARRETIER, Yannick ,  CHARRIER, Jean-Philippe ,  FRANCESCHI, Christine ,  ZAMBARDI, Gilles ,  CECCHINI, Tiphaine ,  DEGOUT-CHARMETTE, Elodie

IPC分类号： G01N33/569

CPC分类号： G01N33/6848 ,  C12Q1/04 ,  C12Q1/37 ,  G01N2333/948 ,  G01N2333/976 ,  G01N2333/986

摘要： The invention relates to a method for the mass spectrometry-based detection of at least one marker of at least one mechanism of resistance to at least one antimicrobial agent, for at least one microorganism included in a sample. The method is characterised in that the antimicrobial agent is a carbapenem, and said resistance markers are proteins or peptides. Preferably, the proteins or peptides are proteins from said microorganism.

摘要翻译： 本发明涉及通过质谱法检测至少一种对至少一种抗微生物抗性的机制的至少一种标记物的方法，所述至少一种抗微生物剂包含在样品中的至少一种微生物的抗性，其特征在于抗微生物剂是 碳青霉烯和所述抗性标记物是蛋白质或肽。 优选地，所述蛋白质或肽是来自所述微生物的蛋白质。

公开(公告)号：EP2430457A2

公开(公告)日：2012-03-21

申请号：EP10720099.0

申请日：2010-05-14

申请人： Biomerieux, Inc

发明人： REMES, Richard, Scott ,  PHILIPAK, Stanley, Michael ,  FANNING, Mark, Joseph ,  ROBINSON, Ronnie, J. ,  BISHOP, James, Clement ,  GUERRA, Lawrence ,  SCHERER, Andrew ,  VALENTINO, Anthony ,  AMMERMAN, Mike ,  BERGOLD, Ron

IPC分类号： G01N35/04

摘要： A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.