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公开(公告)号：EP4452136A1
公开(公告)日：2024-10-30
申请号：EP22843859.4
申请日：2022-12-21
申请人： Université de Bordeaux , Institut National de la Santé et de la Recherche Médicale , Centre Hospitalier Universitaire de Bordeaux , FONDATION BORDEAUX UNIVERSITÉ
IPC分类号： A61F2/24
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3.发明公开
公开(公告)号：EP4185256A1
公开(公告)日：2023-05-31
申请号：EP21749671.0
申请日：2021-07-12
申请人： UNIVERSITE DE BORDEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Centre Hospitalier Universitaire de Bordeaux
发明人： LOPEZ, John , IRIBARREN, Donetsi , TOUBOUL, David
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公开(公告)号：EP4085906A1
公开(公告)日：2022-11-09
申请号：EP21305586.6
申请日：2021-05-06
申请人： UNIVERSITE DE BORDEAUX , Centre Hospitalier Universitaire de Bordeaux , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM
IPC分类号： A61K31/195 , A61K31/216 , A61K31/37 , A61K45/06 , A61P9/00 , A61P43/00
摘要： The present invention belongs to the field of medicine, and more precisely to the field of medecine useful in the treatment of cardiac diseases with contributing mitochondrial dysfunction.
The present invention relates to a composition a pharmaceutical composition comprising a PPAR-modulator and an urolithin derivative of formula I:
wherein R 1 , R 2 and R 3 independently represents H or OH and its use thereof in the treatment of various cardiac diseases linked to cardiac diseases with contributing mitochondrial dysfunction.-
5.发明公开
公开(公告)号：EP3903280A1
公开(公告)日：2021-11-03
申请号：EP19821105.4
申请日：2019-12-19
申请人： UNIVERSITE DE BORDEAUX , Institut Polytechnique de Bordeaux , Centre national de la recherche scientifique , Centre Hospitalier Universitaire de Bordeaux
IPC分类号： G06T7/00
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公开(公告)号：EP3787727A1
公开(公告)日：2021-03-10
申请号：EP19721607.0
申请日：2019-05-02
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公开(公告)号：EP3525860A1
公开(公告)日：2019-08-21
申请号：EP17780783.1
申请日：2017-10-13
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公开(公告)号：EP3505178A1
公开(公告)日：2019-07-03
申请号：EP17306970.9
申请日：2017-12-29
申请人： UNIVERSITE DE BORDEAUX , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , Centre Hospitalier Universitaire de Bordeaux
发明人： BARTHÉLÉMY, Philippe , CRAUSTE-MANCIET, Sylvie , DEVILLARD, Raphaël , DESSANE, Bérangère , SMIRANI, Rawen
IPC分类号： A61K38/17 , A61L27/52 , A61K31/395 , A61K31/712 , C07H19/04 , C07H19/20 , C12N5/071 , B33Y80/00 , A61K47/54 , C08G83/00 , C08J3/075
摘要： The present invention relates to nucleolipid-based compounds for use in regenerative medicine. More specifically, the invention relates to the use of to nucleolipid-based compounds in bioink gel formulations and a bioprinting method comprising the use of a bioink formulation comprising said nucleolipid-based compounds. The invention further relates to a bioprinted construct comprising nucleolipid-based compound(s) and bioink gel formulations.
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9.发明公开SUBSTANCE SELECTED AMONG IRINOTECAN, AN IRINOTECAN ACTIVE METABOLITE, 5-FLUORO-URACILE, A PHARMACEUTICAL SALT THEREOF AND A MIXTURE THEREOF, FOR USE IN THE TREATMENT OF FIBROSIS 审中-公开在IRINOTECAN，IRINOTECAN活性代谢物，5-氟尿嘧啶，其药物盐及其混合物中选择的物质，用于治疗纤维化
公开(公告)号：EP3300733A1
公开(公告)日：2018-04-04
申请号：EP16306275.5
申请日：2016-09-30
发明人： BONNET, Fabrice
IPC分类号： A61K31/4745 , A61K31/513 , A61P21/00
CPC分类号： A61K31/4745 , A61K31/513 , A61K2300/00
摘要： The present invention relates to a substance selected from the group comprising irinotecan, an irinotecan active metabolite, 5-fluoro-uracile, a pharmaceutical salt thereof and a mixture thereof, for use in the treatment of fibrosis.
摘要翻译： 本发明涉及用于治疗纤维化的选自伊立替康，伊立替康活性代谢物，5-氟尿嘧啶，其药用盐及其混合物的物质。
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10.发明公开SYSTEME DE STIMULATION CARDIAQUE ULTRASONORE FOCALISE, DISPOSITIF PORTABLE ET STIMULATION CARDIAQUE, ET METHODES ASSOCIEES 审中-公开SYSTEME DE STIMULATION CARDIAQUE ULTRASONORE FIOCALISE，DISPOSITIF便携式ET刺激CARDIAQUE，ET方法协会
公开(公告)号：EP3188797A1
公开(公告)日：2017-07-12
申请号：EP15756928.6
申请日：2015-09-01
申请人： Université de Bordeaux , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre Hospitalier Universitaire de Bordeaux
CPC分类号： A61N7/02 , A61B5/0044 , A61B5/01 , A61B5/0402 , A61B5/055 , A61B5/107 , A61B5/113 , A61B5/7292 , A61B17/320068 , A61B90/37 , A61B2017/00044 , A61B2017/00084 , A61B2017/00243 , A61B2018/00351 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00839 , A61B2090/373 , A61B2090/374 , A61B2090/378 , A61B2560/0223 , G01R33/4804 , G01R33/4814
摘要： The invention relates to an ultrasound cardiac stimulation system which comprises: a means for measuring the electrical activity of the heart in order to acquire an electrocardiogram (ECG); a means for generating a beam of focussed ultrasound signals (Fus) focussed on a targeted zone (Zc), said signals being calibrated such as to generate electrical stimulation in a zone of the heart, said beam generation being synchronised with a first selected time of the electrocardiogram (ECG), the generation of the beam corresponding to a pulse with a duration of less than 80 ms; a means for locating the targeted zone (Zc) coupled with a means for positioning the means for generating the focussed beam (Fus) so as to control said beam of focussed ultrasound signals (Fus) in the targeted zone (Zc), said location means being synchronised with the means for generating the beam of focussed signals (Fus); a single monitoring means capable of following in real time a temperature and a tissue deformation in the targeted zone (Zc), said monitoring means taking measurements in synchronisation with the rhythm of the electrocardiogram.
摘要翻译： 本发明涉及一种超声心脏刺激系统，其包括：用于测量心脏的电活动以获取心电图（ECG）的装置; 用于生成聚焦在目标区域（Zc）上的聚焦超声信号束（Fus）的装置，所述信号被校准以便在心脏区域中产生电刺激，所述束生成与第一选择时间同步 心电图（ECG），对应于持续时间小于80ms的脉冲的波束的生成; 用于定位与定位用于产生聚焦光束（Fus）的装置的装置耦合的目标区域（Zc）的装置，以便控制所述目标区域（Zc）中的所述聚焦超声信号光束（Fus），所述定位装置 与用于生成聚焦信号光束（Fus）的装置同步; 能够实时跟踪目标区域（Zc）中的温度和组织变形的单个监测装置，所述监测装置与心电图的节律同步地进行测量。
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