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公开(公告)号：EP2142921B1
公开(公告)日：2020-01-01
申请号：EP08748117.2
申请日：2008-04-10
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2.发明公开METHOD OF CALIBRATION FOR THE REPRESENTATION OF KNEE KINEMATICS AND HARNESS FOR USE THEREWITH 审中-公开校准程序膝关节运动学和支持物的PRESENTATION
公开(公告)号：EP1458289A2
公开(公告)日：2004-09-22
申请号：EP02787249.8
申请日：2002-12-11
申请人： Ecole de Technologie Supérieure , Centre Hospitalier de l'Université de Montréal ( CHUM) , Polyvalor, Société en Commandite
发明人： DE GUISE, Jacques, A. , YAHIA, L'Hocine , DUVAL, Nicolas , HAGEMEISTER, Nicola , PARENT, Gerald , ST-ONGE, Nancy , KOLLER, Annick , ANGUELOV, Borislav , EL MAACH, Ismail
IPC分类号： A61B5/103
CPC分类号： A61B5/4528 , A61B5/103 , A61B5/6828 , A61B5/6831
摘要： A method for creating a frame of reference of a leg of a subject for subsequent 3-D kinematic analysis of the leg with non-invasive trackable references secured to the femur and the tibia of the leg. The method comprises the steps of: i) obtaining tibial and femoral axes with respect to the trackable references by tracking points and motions of the leg; ii) registering a known posture of the subject with respect to the trackable references; iii) obtaining a desired posture of the subject with respect to the trackable references as a function of the known posture by tracking a predetermined motion of the leg; and iv) setting a frame of reference to said tibial and femoral axes of the leg in the desired posture of the subject with respect to the trackable references.
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公开(公告)号：EP3233919A1
公开(公告)日：2017-10-25
申请号：EP15868788.9
申请日：2015-12-17
发明人： PRAT, Alexandre , GHANNAM, Soufiane
IPC分类号： C07K16/28 , C07K16/18 , C12N5/0783 , C07K16/42
CPC分类号： C07K16/2803 , A61K2039/505 , A61P25/00 , A61P37/00 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/76
摘要： Novel antibodies directed against Dual Ig domain containing cell adhesion molecule (DICAM) are described. These anti-DICAM antibodies are capable of detecting DICAM by Western blot and/or flow cytometry, blocking the interaction between DICAM and its ligand αVβ3 integrin, and/or blocking the migration of inflammatory cytokine-secreting TH17 lymphocytes across the blood brain barrier. Uses of these antibodies or compositions comprising same for the diagnosis, prevention and/or treatment of autoimmune/inflammatory conditions, such as neuroinflammatory conditions, and for the targeting, identification and selection of inflammatory cytokine-secreting TH17 lymphocytes or precursor thereof are also disclosed.
摘要翻译： 描述了针对含双Ig结构域的细胞粘附分子（DICAM）的新型抗体。 这些抗DICAM抗体能够通过Western印迹和/或流式细胞术检测DICAM，阻断DICAM与其配体αVβ3整联蛋白之间的相互作用，和/或阻断分泌炎性细胞因子的T H17淋巴细胞穿过血脑屏障的迁移 。 这些抗体或包含它们的组合物用于诊断，预防和/或治疗自身免疫性/炎症性病症如神经炎症病症以及用于靶向，鉴定和选择分泌炎性细胞因子的T H17淋巴细胞或其前体也被公开 。
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公开(公告)号：EP4095265A1
公开(公告)日：2022-11-30
申请号：EP21305694.8
申请日：2021-05-26
申请人： Université Paris-Saclay , INSERM (Institut National de la Santé et de la Recherche Médicale) , Assistance Publique-Hôpitaux de Paris , Centre Hospitalier de l'Université de Montréal
IPC分类号： C12Q1/6883
摘要： The present invention proposes to detect genetic abnormalities (mutations and LOH) in the KDM1A gene of subjects, in order to diagnose a genetic predisposition to an endocrine disease and/or to an endocrine hyperplasia / or adenoma formation. Also, it proposes to treat patients with GIP-dependent PBMAH with Cushing's syndrome by restoring the expression of the KDM1A gene, by gene therapy.
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5.发明授权A SYSTEM AND METHOD FOR DETECTION, CHARACTERIZATION AND IMAGING OF HETEROGENEITY USING SHEAR WAVE INDUCED RESONANCE 有权对于检测，表征并使用一个BY横波的非均质性图片系统和方法会造成响应
公开(公告)号：EP2310829B1
公开(公告)日：2016-04-06
申请号：EP09802318.7
申请日：2009-07-30
CPC分类号： A61B8/406 , A61B5/0051 , A61B5/0057 , A61B5/02007 , A61B8/08 , A61B8/0825 , A61B8/4218 , A61B8/4405 , A61B8/4461 , A61B8/485 , A61B8/5215 , A61B8/587 , A61N7/02 , G01H13/00 , G01N29/0654 , G01N29/12 , G01N2291/02475 , G01N2291/0422
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公开(公告)号：EP2739608A1
公开(公告)日：2014-06-11
申请号：EP12819370.3
申请日：2012-07-31
IPC分类号： C07D213/40 , A61K31/27 , A61K31/4409 , A61P3/10 , A61P5/50 , C07C271/44
CPC分类号： C07D213/40 , C07C271/44
摘要： The present disclosure relates to novel compounds, compositions containing same and methods for treating or preventing a condition associated with a deficient insulin secretion such as diabetes and metabolic syndrome in a subject in need thereof.
摘要翻译： 本公开涉及新型化合物，含有其的组合物以及用于在有需要的受试者中治疗或预防与胰岛素分泌不足（例如糖尿病和代谢综合征）有关的病症的方法。
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7.发明公开
公开(公告)号：EP1690230A1
公开(公告)日：2006-08-16
申请号：EP04818371.9
申请日：2004-11-15
CPC分类号： A61B5/02007 , A61B8/0858 , G06K9/34 , G06K9/6278 , G06K2209/05 , G06T7/12 , G06T7/149 , G06T2207/10132 , G06T2207/20161 , G06T2207/30101
摘要： The present invention generally relates to intravascular ultrasound (IVUS) image segmentation methods, and is more specifically concerned with an intravascular ultrasound image segmentation method for characterizing blood vessel vascular layers. The proposed image segmentation method for estimating boundaries of layers in a multi-layered vessel provides image data which represent a plurality of image elements of the multi-layered vessel. The method also determines a plurality of initial interfaces corresponding to regions of the image data to segment and further concurrently propagates the initial interfaces corresponding to the regions to segment. The method thereby allows to estimate the boundaries of the layers of the multi-layered vessel by propagating the initial interfaces using a fast marching model based on a probability function which describes at least one characteristic of the image elements.
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公开(公告)号：EP1178759A1
公开(公告)日：2002-02-13
申请号：EP00930897.4
申请日：2000-05-12
CPC分类号： F16M11/126 , A61B90/361 , A61B90/50 , F16M11/18 , F16M11/2014 , F16M11/2064 , F16M11/2092 , F16M13/00 , F16M13/027 , F21W2131/205 , G05B2219/40169 , G05B2219/40613 , G05B2219/45169
摘要： A controllable camera support including a pivoting arm adapted to be rotatably connected to a pivot point defining a first rotational axis. The pivoting arm also defines a radial axis. The camera support also includes a camera holder mounted on the pivoting arm. The camera holder is displaceable along the radial axis. The camera further includes motors coupled to the pivoting arm and to the camera holder. The motors are adapted to impart rotational and radial motions to the camera holder. The camera support also includes a control device for controlling the motors. The invention also covers a system further including a focal adjustable, rotational, tilting camera mounted on the camera holder. When a target that is focused by the camera becomes obstructed, the control device is adapted to move the camera to another position all the while focusing on the target.
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公开(公告)号：EP4351647A1
公开(公告)日：2024-04-17
申请号：EP22821089.4
申请日：2022-06-10
申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , Centre Hospitalier de l'Université de Montréal
IPC分类号： A61K39/42
CPC分类号： C07K16/1045 , C07K2317/73220130101 , A61P31/18 , C07K2317/62220130101 , C07K2317/2220130101
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公开(公告)号：EP4347888A1
公开(公告)日：2024-04-10
申请号：EP22730465.6
申请日：2022-05-24
申请人： Université Paris-Saclay , Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique - Hôpitaux de Paris , Centre Hospitalier de l'Université de Montréal
IPC分类号： C12Q1/6883
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