公开(公告)号：EP4427760A3

公开(公告)日：2024-11-13

申请号：EP24174240.2

申请日：2017-07-13

申请人： Children's Medical Center, Corp. ,  Dana-Farber Cancer Institute

发明人： BRADNER, James ,  QI, Jun ,  BUCKLEY, Dennis ,  ZON, Leonard I ,  MACARI, Elizabeth

IPC分类号： A61K31/4375 ,  A61K31/145 ,  A61K31/4418 ,  A61P7/06 ,  A61K45/06 ,  A61K31/4045 ,  A61K31/519 ,  A61K31/7048 ,  A61K31/541

摘要： The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

公开(公告)号：EP3925670A1

公开(公告)日：2021-12-22

申请号：EP21170894.6

申请日：2010-12-17

申请人： Children's Medical Center, Corp.

发明人： WATNICK, Randolph

IPC分类号： A61P35/00 ,  A61K38/00 ,  C07K14/475

摘要： The invention relates to isolated peptides and chimeric polypeptides derived from Saposin A that have anti-angiogenic activity. These peptides are small, consisting essentially of at least 10 consecutive amino acid residues from the 3 lst-50th amino acid residue of Saposin A. The invention also relates to the use of these isolated peptides and chimeric polypeptides in compositions for the treatment, prevention, and inhibition of angiogenesis-related diseases and disorders such as cancer and cancer metastasis.

公开(公告)号：EP3919070A1

公开(公告)日：2021-12-08

申请号：EP21171264.1

申请日：2014-03-13

申请人： Children's Medical Center, Corp.

发明人： WATNICK, Randolph, S.

IPC分类号： A61K38/18 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574 ,  A61P35/00

摘要： Provided herein are methods for identifying a subject with cancer for treatment with a Psap peptides. The subject is identified based on a level of CD36. Also provided herein are compositions and methods for treatment of a subject with cancer based on a level of CD36.

公开(公告)号：EP3185910A4

公开(公告)日：2018-01-10

申请号：EP15835677

申请日：2015-08-28

申请人： CHILDREN'S MEDICAL CENTER CORP

发明人： WHEELER LEE ADAM ,  LIEBERMAN JUDY ,  GILBOA-GEFFEN ADI

IPC分类号： A61K48/00 ,  C12N15/115

CPC分类号： C12N15/115 ,  A61K48/00 ,  A61K2039/5152 ,  C07H21/00 ,  C07K14/705 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/3519 ,  C12N2310/322 ,  C12N2310/3533

摘要： Described herein are methods and compositions relating to the treatment of cancer, e.g., breast cancer, using, e.g., aptamer-siRNA chimera molecules.

公开(公告)号：EP3060259A4

公开(公告)日：2017-11-15

申请号：EP14855464

申请日：2014-10-24

申请人： CHILDREN'S MEDICAL CENTER CORP

发明人： SMITH LOIS ,  SHAO ZHUO

IPC分类号： A61K31/47 ,  A61K31/202 ,  A61K31/216 ,  A61K45/06 ,  A61P9/00 ,  A61P27/02

CPC分类号： A61K31/47 ,  A01K67/0275 ,  A01K2207/25 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/03 ,  A61K31/202 ,  A61K31/216 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP3131579A4

公开(公告)日：2017-10-25

申请号：EP15779219

申请日：2015-04-17

申请人： THE CHILDREN'S MEDICAL CENTER CORP

发明人： VAN HAREN SIMON D ,  LEVY OFER ,  DOWLING DAVID J

IPC分类号： A61K39/39 ,  A61K35/74

CPC分类号： A61K39/39 ,  A61K35/74 ,  A61K2039/57

公开(公告)号：EP3092494A4

公开(公告)日：2017-10-18

申请号：EP15733141

申请日：2015-01-06

申请人： CHILDREN'S MEDICAL CENTER CORP

发明人： BARNABY OMAR S ,  STEEN JUDITH AJ ,  STEVENS BETH ,  STEEN HANNO ,  HONG SOYON Y

IPC分类号： G01N33/68 ,  G01N33/53

CPC分类号： G01N33/6896 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/60

公开(公告)号：EP3096609A4

公开(公告)日：2017-06-21

申请号：EP15739843

申请日：2015-01-23

申请人： CHILDREN'S MEDICAL CENTER CORP

发明人： ALT FREDERICK ,  CHENG HWEI-LING ,  TIAN MING

IPC分类号： A01K39/00 ,  A01K67/027 ,  C07H21/04 ,  C07K16/00 ,  C12N5/07 ,  C12N15/85 ,  C12P21/08

CPC分类号： A01K67/0278 ,  A01K67/0271 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  C07K16/00 ,  C07K16/1045 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/8509 ,  C12N2015/8518 ,  C12N2015/8527 ,  C12N2800/30

摘要： Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.

摘要翻译： 本文描述的是与工程Ig基因座有关的组合物（例如细胞和转基因动物）和方法，其允许特定抗体或抗体片段的表达，同时仍允许用于抗体优化的重组和/或成熟过程。

公开(公告)号：EP3033622A4

公开(公告)日：2017-05-31

申请号：EP14836502

申请日：2014-08-12

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL INC ,  CHILDREN'S MEDICAL CENTER CORP

发明人： GREENBERG STEVEN

IPC分类号： G01N33/564

CPC分类号： G01N33/6854 ,  G01N33/564 ,  G01N2333/916 ,  G01N2800/10 ,  G01N2800/50

公开(公告)号：EP2981617A4

公开(公告)日：2017-01-11

申请号：EP14779492

申请日：2014-04-04

申请人： HARVARD COLLEGE ,  THE CHILDREN'S MEDICAL CENTER CORP

发明人： MUSUNURU KIRAN ,  COWAN CHAD A ,  ROSSI DERRICK J

IPC分类号： C12N15/87 ,  C12N15/00 ,  C12N15/11

CPC分类号： C12N15/63 ,  A61K48/00 ,  C12N15/907