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    ANTIMICROBIAL COMPOSITION COMPRISING FILOBASIDIUM-SUPPRESSING AGENT DERIVED FROM NATURAL SUBSTANCE
    1.
    发明公开
    ANTIMICROBIAL COMPOSITION COMPRISING FILOBASIDIUM-SUPPRESSING AGENT DERIVED FROM NATURAL SUBSTANCE 审中-公开
    与Filobasidium抗菌成分进行抑制的一种天然物质获得的资金

    公开(公告)号：EP2883549A1

    公开(公告)日：2015-06-17

    申请号：EP13825689.6

    申请日：2013-05-06

    申请人： Chung-Ang University Industry-Academy Cooperation

    发明人： KIM, Won Yong ,  PARK, Sang Gue ,  PARK, Hee Kuk

    IPC分类号： A61K36/744 ,  A61K36/75 ,  A61K36/78 ,  A61P31/04

    CPC分类号： A61K36/75 ,  A61K8/97 ,  A61K36/185 ,  A61K36/31 ,  A61K36/42 ,  A61K36/744 ,  A61K36/78 ,  A61K2800/59 ,  A61Q5/006 ,  A61Q17/005 ,  A61K2300/00

    摘要： The present invention relates to an antimicrobial composition derived from a natural substance. Since the composition effectively suppresses Filobasidium , an organism that has been newly identified as causing dandruff, the present invention can effectively prevent and/or treat seborrhoeic dermatitis and dandruff. Also, since the antimicrobial composition of the present invention includes a natural substance as an active ingredient, little consumer aversion will result. Also, it is expected that the antimicrobial composition of the present invention can be used for developing an antidandruff agent having a reduced content of materials which are typically used as antidandruff agents and the safety of which is questionable.

    摘要翻译： 本发明涉及在从天然物质衍生的抗微生物组合物。 由于该组合物有效地抑制Filobasidium，对生物体没有头皮屑已经被新确定为导致头皮屑，本发明可以有效地防止和/或治疗脂溢性皮炎和。 这样，由于本发明的抗微生物组合物包括天然物质作为活性，小消费者厌恶成分将导致。 所以，预期也可用于具有其通常用作去头屑剂材料含量降低和所有的安全性是有问题的去头屑剂的开发本发明的抗微生物组合物。

    RDNA NTS BASED GENE MULTIPLE INSERTION CASSETTE SET AND GRAS-GRADE RECOMBINANT YEAST STRAIN
    2.
    发明公开
    RDNA NTS BASED GENE MULTIPLE INSERTION CASSETTE SET AND GRAS-GRADE RECOMBINANT YEAST STRAIN 审中-公开
    基于RDNA NTS的基因多重插入片段集和GRAS-GRADE重组酵母菌株

    公开(公告)号：EP3184639A1

    公开(公告)日：2017-06-28

    申请号：EP14900237.0

    申请日：2014-12-30

    申请人： Chung-Ang University Industry-Academy Cooperation Foundation

    发明人： KANG, Hyun Ah ,  MOON, Hye Yun ,  KIM, Hong Jin

    IPC分类号： C12N15/70 ,  C12N1/19 ,  C12R1/865 ,  A61K39/00

    CPC分类号： C12N15/81 ,  A61K9/0053 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/523 ,  A61K2039/54 ,  C07K14/005 ,  C12N15/70 ,  C12N2770/30022 ,  C12N2770/30034 ,  C12N2770/30071 ,  C12R1/865

    摘要： The present invention relates to a ribosomal DNA nontranscribed spacer (rDNA NTS)-based gene multiple insertion cassette set and a GRAS-grade recombinant yeast strain using the same. In particular, a gene multiple insertion cassette set including rDNA NTS fragments and an auxotrophic selection marker having an incomplete promoter is developed, and a safe oral recombinant strain having no antibiotic resistant marker is constructed by multiple insertion of an optimum number of the developed gene multiple insertion cassette sets into chromosomes of a Saccharomyces cerevisiae strain. In addition, the present invention provides a vaccine composition including, as an active ingredient, the above strain, a culture product thereof, a cell lysate, or nodavirus capsid protein (NNVcp) isolated and purified therefrom. In addition, the present invention provides a composition for feed addition including, as an active ingredient, the above strain, a culture product thereof, a cell lysate, or squalene or oxidosqualene isolated and purified therefrom. Furthermore, the present invention provides a technique of preparing a GRAS-grade recombinant yeast strain for mass production of various recombinant proteins or useful metabolites.

    摘要翻译： 本发明涉及基于核糖体DNA非转录间隔区（rDNA NTS）的基因多重插入盒组和使用其的GRAS级重组酵母株。 特别地，开发了包含rDNA NTS片段的基因多重插入盒组和具有不完全启动子的营养缺陷型选择标记，并且通过多次插入最适数量的显现基因倍数构建不具有抗生素抗性标记的安全口服重组菌株 插入盒置于酿酒酵母菌株的染色体中。 此外，本发明提供了一种疫苗组合物，其包含从其分离和纯化的上述菌株，其培养产物，细胞裂解物或诺达病毒衣壳蛋白（NNVcp）作为活性成分。 此外，本发明提供了一种用于饲料添加的组合物，其包含作为活性成分的上述菌株，其培养产物，细胞裂解物或由其分离和纯化的角鲨烯或氧化角鲨烯。 此外，本发明提供了制备用于大量生产各种重组蛋白质或有用代谢物的GRAS级重组酵母菌株的技术。

    PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OVARY GRANULOSA CELL TUMORS CONTAINING GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITOR AS ACTIVE INGREDIENT, AND FUNCTIONAL HEALTH FOOD COMPOSITION
    6.
    发明公开
    PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OVARY GRANULOSA CELL TUMORS CONTAINING GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITOR AS ACTIVE INGREDIENT, AND FUNCTIONAL HEALTH FOOD COMPOSITION 审中-公开
    用于预防药物组合物卵巢，卵巢颗粒治疗糖原合酶激酶3 BETA抑制剂主动和功能性保健食品成分

    公开(公告)号：EP2979696A1

    公开(公告)日：2016-02-03

    申请号：EP14772608.7

    申请日：2014-03-27

    申请人： Chung-Ang University Industry-Academy Cooperation Foundation

    发明人： BAE, Jeehyeon ,  LEE, Kangseok ,  KIM, Jaehong

    IPC分类号： A61K31/40 ,  A61K31/404 ,  A61K31/4035 ,  A61P35/00

    CPC分类号： A61K31/426 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/404

    摘要： The present invention relates to a pharmaceutical composition for preventing or treating ovary granulosa cell tumors containing, as an active ingredient, one selected from the group consisting of a compound represented by chemical formula 1, a pharmaceutically acceptable salt of the compound represented by chemical formula 1, a compound represented by chemical formula 2, and a pharmaceutically acceptable salt of the compound represented by chemical formula 2, or a functional health food composition. The composition according to the present invention inhibits glycogen synthase kinase-3 beta (GSK3beta) and thus has an effect of inhibiting a phosphorylation of a serine, which is the 33rd amino acid of the forkhead box L2 (FOXL2) protein, by containing, as an active ingredient, one selected from the group consisting of the compound represented by chemical formula 1, the pharmaceutically acceptable salt of the compound represented by chemical formula 1, the compound represented by chemical formula 2, and the pharmaceutically acceptable salt of the compound represented by chemical formula 2, so that the composition can be useful as a composition for preventing or treating ovary granulosa cell tumors. Further, the composition according to the present invention is expected to be also useful as a functional health food composition.

    摘要翻译： 本发明涉及一种药物组合物，用于预防或治疗含有作为活性成分的，选自以化学式1表示的化合物中选择的一个卵巢颗粒细胞瘤，所述化合物的药学上可接受的盐由化学式1表示 通过化学式2表示的化合物，以及由化学式2或功能性保健食品组合物表示的化合物的药学上可接受的盐。 雅丁到本发明的组合物抑制糖原合酶激酶-3β（GSK3beta），因此具有以实现抑制丝氨酸的磷酸化，在所有这是叉头框L2（FOXL2）蛋白质，由含第33氨基酸，如 成分活性，选自由化学式1表示的化合物中选择的一个，所述化合物的药学上可接受的盐由化学式1表示，所述化合物由化学式2表示，并且该化合物的代表由药学上可接受的盐 化学式2中，所以没组合物可以是如用于预防或治疗卵巢颗粒细胞瘤的组合物是有用的。 此外，组合物gemäß到本发明预期为作为功能性健康食品组合物非常有用。

    Apparatus and method for registering node and searching for floating internet protocol address using distributed network
    9.
    发明公开
    Apparatus and method for registering node and searching for floating internet protocol address using distributed network 有权
    装置和方法用于可变互联网协议地址的节点和搜索的登记使用分布式网络

    公开(公告)号：EP2375692A2

    公开(公告)日：2011-10-12

    申请号：EP10014205.8

    申请日：2010-11-02

    申请人： Chung-Ang University Industry-Academy Cooperation Foundation

    发明人： Cho, Sung, Rae ,  Jung, Hyun, Ki

    IPC分类号： H04L29/08 ,  H04L29/12

    CPC分类号： H04L61/1541 ,  H04L29/12113 ,  H04L67/104 ,  H04L67/1089

    摘要： A method of registering a new node in a network and a method of searching for a floating Internet Protocol (IP) address through a distributed network are provided. The method of searching for the floating IP address may include receiving, by a representative node of a head network ring, from an external node, a message comprising an Identification (ID) of a target node, determining whether the ID of the target node is registered in the head network ring, based on a ring information table, and transferring the message to a representative node of a child ring having an address range of the target node among child rings, when the ID of the target node is not registered in the head network ring.

    摘要翻译： 注册在网络中和一个新节点搜索浮动因特网协议的一个方法的方法（IP）通过分布式网络地址被提供。 搜索浮动IP地址的方法可以包括接收，由磁头网络环的代表节点，从外部节点，该消息包括的一个目标节点的标识（ID），确定性采矿无论所述目标节点的ID是 在头网络环注册的基础上，环信息表，和转移环的消息给具有处理子环中的目标节点，的范围的子环的代表节点当目标节点的ID没有在登记的 头网络环。