公开(公告)号：EP4387735A2

公开(公告)日：2024-06-26

申请号：EP22868219.1

申请日：2022-08-11

申请人： SOUTHWEST RESEARCH INSTITUTE ,  The Government of The United States, as Represented by The Secretary of The Army ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： BOHMANN, Jonathan A. ,  GUTIERREZ, Nadean M. ,  MCDONOUGH, Joseph A. ,  CAMPBELL, Robert Francis ,  JOYCE, Michael Gordon ,  PANCHAL, Rekha ,  SANKHALA, Rajeshwer ,  DUPLANTIER, Allen

IPC分类号： A61P31/14 ,  A61K31/4184 ,  C07D235/04

CPC分类号： A61K31/445 ,  A61K31/4184

公开(公告)号：EP4046151A1

公开(公告)日：2022-08-24

申请号：EP19949457.6

申请日：2019-11-18

申请人： The Government of The United States, as represented by The Secretary of The Army

发明人： SMOLEK, Michael, K.

IPC分类号： G09B23/30

公开(公告)号：EP2560633B8

公开(公告)日：2020-08-12

申请号：EP11772752.9

申请日：2011-04-22

申请人： The Government of the United States, as represented by The Secretary of the Army

发明人： LEWIS, Michael

IPC分类号： A61K9/107 ,  A61K47/14 ,  A61K31/202 ,  A61K31/201 ,  A61P25/28

公开(公告)号：EP3548034A1

公开(公告)日：2019-10-09

申请号：EP17878089.6

申请日：2017-12-05

申请人： Microbiotix, Inc. ,  Albert Einstein College of Medicine, Inc. ,  The Government of the United States, as represented by the Secretary of the Army

发明人： BOWLIN, Terry, L. ,  MOIR, Donald, T. ,  CHANDRAN, Kartik ,  DYE, John M, Jr. ,  WILLIAMS, John, D. ,  ARON, Zachary, D. ,  BARBOR, Katherine, S. ,  LIVELY, Kelly, N. ,  NASH, Peter, J. ,  MILLS, Debra, M. ,  BASU, Arnab

IPC分类号： A61K31/551 ,  C07D401/04

公开(公告)号：EP2694542A2

公开(公告)日：2014-02-12

申请号：EP12768353.0

申请日：2012-04-09

申请人： Duke University ,  The Government of The United States, as represented by The Secretary of The Army, on behalf of Walter Reed Army

发明人： HAYNES, Barton, F. ,  LIAO, Hua-Xin ,  MOODY, M., Anthony ,  TOMARAS, Georgia, D. ,  KIM, Jerome ,  MICHAEL, Nelson

IPC分类号： C07K16/08 ,  C07K16/28 ,  C12N15/13 ,  A61K39/42 ,  A61P31/22

CPC分类号： C07K16/087

摘要： The present invention relates, in general to herpes simplex virus (HSV) and, particular, to antibodies that are specific for glycoprotein D (gD) of HSV. The invention also relates to prophylactic and therapeutic uses of such antibodies.

公开(公告)号：EP2286834A3

公开(公告)日：2012-01-25

申请号：EP10012335.5

申请日：1999-02-25

申请人： THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY

发明人： Glenn, Gregory, Dr. ,  Alving, Carl

IPC分类号： A61K39/39 ,  A61K9/00 ,  C12N15/11 ,  A61K39/00 ,  A61K38/16 ,  A61K39/02 ,  A61K39/106

CPC分类号： A61K47/10 ,  A61K9/0014 ,  A61K9/7023 ,  A61K39/00 ,  A61K39/39 ,  A61K47/08 ,  A61K47/12 ,  A61K2039/55522 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/55572 ,  Y02A50/472

摘要： Disclosed is a formulation comprising an antigen and an adjuvant for transcutancous immunization of a subject, wherein the antigen induces an immune response specific for the antigen following application of the formulation to the subject's unperforated skin which is treated to disrupt the stratum corneum.

公开(公告)号：EP1716200A1

公开(公告)日：2006-11-02

申请号：EP05722491.7

申请日：2005-01-21

申请人： UNIVERSITY OF MASSACHUSETTS LOWELL ,  Government of the United States as represented by the Secretary of the Army

发明人： CHOLLI, Ashok, L. ,  KUMAR, Vijayendra ,  DHAWAN, Ashish ,  KUMAR, Jayant ,  PARMAR, Virinder, S. ,  SAMUELSON, Lynne, A. ,  BRUNO, Ferdinando, F.

IPC分类号： C08K5/00

摘要： One group of polymers comprise repeat units of Structural Formula (I) and/or (II) where: R is -H or a substituted or unsubstituted alkyl, acyl or aryl group; Rings A and B are substituted with at least one tert-butyl group, 1-ethenyl-2-carboxylic acid group or ester thereof, substituted or unsubstituted alkylenedioxy group, or substituted or unsubstituted n-alkoxycarbonyl group and optionally additional functional groups; Ring B is additionally substituted with at least one -H; n is equal to or greater than 2; and p is equal to or greater than 0. The polymer typically includes at least two substituted benzene repeat units that are directly connected by C-C or C-O-C bonds between benzene rings. Alternatively, each repeat unit of the polymer is an antioxidant. The invention also includes methods of making and using these and related polymers, particularly as antioxidants.

公开(公告)号：EP1061951B1

公开(公告)日：2003-08-27

申请号：EP99936034.0

申请日：1999-02-25

申请人： THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY

发明人： GLENN, Gregory, M. ,  ALVING, Carl, B.

IPC分类号： A61K39/39 ,  A61K9/00 ,  C12N15/11

CPC分类号： A61K47/10 ,  A61K9/0014 ,  A61K9/7023 ,  A61K39/00 ,  A61K39/39 ,  A61K47/08 ,  A61K47/12 ,  A61K2039/55522 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/55572 ,  Y02A50/472

摘要： Disclosed is a formulation comprising an antigen and an adjuvant for transcutancous immunization of a subject, wherein the antigen induces an immune response specific for the antigen following application of the formulation to the subject's unperforated skin which is treated to disrupt the stratum corneum.

公开(公告)号：EP1159071A1

公开(公告)日：2001-12-05

申请号：EP99961769.9

申请日：1999-11-22

申请人： THE GOVERNMENT OF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY

发明人： IBRAHIM, M., Sofi

IPC分类号： B01L3/00 ,  G01N1/34 ,  G01N33/543

CPC分类号： B01L3/508 ,  G01N1/34 ,  G01N33/54366 ,  G01N2001/028 ,  G01N2001/2826 ,  Y10T436/143333

摘要： A purification apparatus (1), kit and method for purifying DNA, RNA, proteins, antigens, antibodies and cells. The apparatus (1) has a wand (2) and a reservoir tube (6). The wand (2) is made of a cap (5), a sample collection assembly (4) and an elongated shaft (3) connecting the cap (5) to the sample collection assembly (4). The sample collection (4) assembly has a series of microstructures (13) on its surface, or microparticles enclosed within it for increasing the surface area of the sample collection assembly (4). The increased surface area permits maximum exposure to and binding of target molecules thereto. The reservoir tube (6) associated with the wand (2) has one end defining an opening and a second end that is closed and preferably cone or cylindrical shaped. The cap (5) of the wand securely and sealingly fastens to the open end of the reservoir tube (6) with the shaft (3) and the sample collection (4) assembly fitting easily inside the reservoir tube.

公开(公告)号：EP4362780A1

公开(公告)日：2024-05-08

申请号：EP22834322.4

申请日：2022-07-01

申请人： The Government of the United States, as represented by the Secretary of the Army ,  The Secretary of State for Defence of the United Kingdom of Great Britain and Northern Ireland

发明人： BULLER, Mark Jonathan ,  DELVES, Simon K.

IPC分类号： A61B5/0205 ,  A61B5/024 ,  G16H10/60

CPC分类号： A61B5/02055 ,  A61B2562/027120130101 ,  A61B5/746 ,  A61B5/7282 ,  G16H50/30