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公开(公告)号：EP4223751A1
公开(公告)日：2023-08-09
申请号：EP21874584.2
申请日：2021-09-30
申请人： Humanwell Healthcare (Group) Co., Ltd. , Wuhan Humanwell Innovative Drug Research and Development Center Limited Company
发明人： ZHANG, Xuejun , ZANG, Yang , LI, Xueqiang , YANG, Chengbing , WANG, Yonggang , ZHANG, Bo , LI, Yang , LIU, Lifei , YANG, Jun , LI, Lie
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61K31/506 , A61K31/501 , A61P25/28 , A61P13/08 , A61P25/04 , A61P13/00 , A61P29/00
摘要： Provided are a novel compound that effectively antagonizes P2X3 receptor, a preparation method thereof, and use thereof in the preparation of drugs. The compound is a compound represented by Formula I, or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof.
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公开(公告)号：EP3372594A1
公开(公告)日：2018-09-12
申请号：EP16861623.3
申请日：2016-11-04
发明人： WANG, Xuehai , XU, Yong , SHENG, Xijun , ZHANG, Xiaolin , XIA, Hangui , YANG, Zhongwen , YUE, Yang , HUANG, Lu , XIAO, Qiang
IPC分类号： C07D409/12 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D239/48 , A61K31/5377 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61K9/0019 , A61K9/08 , A61K9/12 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/5377 , A61K45/06 , A61K2300/00 , A61P35/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R 1 , R 2 , R 3 , R 4 and R 5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.
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3.发明公开ANALOGUES OF 4H-PYRAZOLO[1,5- ]BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS 审中-公开类似物EINER 4H-PYRAZOLO [1,5-A] BENZIMIDAZOL-VERBINDUNG ALS PARP-HEMMER
公开(公告)号：EP3130592A4
公开(公告)日：2017-09-06
申请号：EP15777444
申请日：2015-03-30
申请人： HUBEI BIO-PHARMACEUTICAL IND TECH INST INC , HUMANWELL HEALTHCARE (GROUP) CO LTD , MEDSHINE DISCOVERY INC
发明人： DING ZHAOZHONG , CHEN SHUHUI , LI GANG , WANG CAILIN , ZHANG ZHIBO , TU RONGHUA , WANG CAILIN , YUE YANG , ZHANG ZHIBO , CHEN HAILIANG , SUN WENJIE , HUANG LU
IPC分类号： C07D487/04 , A61P3/10 , A61P9/10 , A61P25/00 , A61P29/00 , A61P35/00 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Disclosed is a series of analogues of 4H-pyrazolo[1,5-a]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.
摘要翻译： 公开了一系列作为PARP抑制剂的4H-吡唑并[1,5-a]苯并咪唑化合物的类似物。 特别地，本发明公开了式（I）所示的化合物或其药学上可接受的盐作为PARP抑制剂。
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4.发明公开ANALOGUES OF 4H-PYRAZOLO[1,5- ]BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS 审中-公开ANALOGA EINER 4H-PYRAZOLO [1,5-A]苯并咪唑-VERBINDUNG ALS PARP-HEMMER
公开(公告)号：EP3130592A1
公开(公告)日：2017-02-15
申请号：EP15777444.9
申请日：2015-03-30
申请人： Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. , Humanwell Healthcare (Group) Co., Ltd. , Medshine Discovery Inc.
发明人： DING, Zhaozhong , CHEN, Shuhui , LI, Gang , WANG, Cailin , ZHANG, Zhibo , TU, Ronghua , WANG, Cailin , YUE, Yang , ZHANG, Zhibo , CHEN, Hailiang , SUN, Wenjie , HUANG, Lu
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00 , A61P25/00 , A61P9/10 , A61P29/00 , A61P3/10
CPC分类号： C07D487/04 , C07D519/00
摘要： Disclosed is a series of analogues of 4H-pyrazolo[1,5-a]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.
摘要翻译： 公开了一系列4H-吡唑并[1,5-a]苯并咪唑化合物的类似物作为PARP抑制剂。 特别地，本发明中公开的是式（I）所示的化合物或其药学上可接受的盐作为PARP抑制剂。
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公开(公告)号：EP3130592B1
公开(公告)日：2019-08-14
申请号：EP15777444.9
申请日：2015-03-30
申请人： Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. , Humanwell Healthcare (Group) Co., Ltd.
发明人： DING, Zhaozhong , CHEN, Shuhui , LI, Gang , WANG, Cailin , ZHANG, Zhibo , TU, Ronghua , WANG, Cailin , YUE, Yang , ZHANG, Zhibo , CHEN, Hailiang , SUN, Wenjie , HUANG, Lu
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00 , A61P25/00 , A61P9/10 , A61P29/00 , A61P3/10
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6.发明公开DESMODIUM STYRACIFOLIUM (OSB.) MERR. FLAVONOIDS CAPSULE, METHOD OF PREPARING SAME, AND APPLICATION THEREOF 审中-公开DESMODIUM-STYRACIFOLIUM-（OSB。）{J} -MERR。{J} -FLAVONOIDENKAPSEL，VERFAHREN ZUR HERSTELLUNG DAVON ANDD ANWENDUNG DAVON
公开(公告)号：EP3078380A4
公开(公告)日：2017-05-24
申请号：EP14868261
申请日：2014-07-15
申请人： WUHAN OPTICS VALLEY HUMANWELL BIO-PHARMACEUTICAL CO LTD , HUBEI BIO-PHARMACEUTICAL IND TECH INST INC , WUHAN CHEMLIGAND BIO-PHARMACEUTICAL CO LTD , HUMANWELL HEALTHCARE (GROUP) CO LTD
发明人： WANG XUEHAI , XU YONG , LI LI'E , LI JIE , TU RONGHUA , CHEN GANG , CAO RUBIN , FENG YUN , YANG ZHONGWEN , FAN ZHAOZE , YU YANPING , XIAO QIANG , HUANG LU , YANG CHENGBING , HUANG TIANCI , TIAN HUA , YANG JING
CPC分类号： A61K36/48 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1682 , A61K9/4833 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K2236/33 , A61K2236/53
摘要： A capsule containing total flavonoids of Desmodium styracifolium, a method for preparing the same and a use of the capsule containing total flavonoids of Desmodium styracifolium are provided. Specifically, the capsule includes total flavonoids of Desmodium Styracifolium provided in a form of alcohol extract of Desmodium Styracifolium and a pharmaceutically acceptable excipient.
摘要翻译： 提供了含有广金钱草总黄酮的胶囊，其制备方法和使用含有金钱草总黄酮的胶囊。 具体而言，所述胶囊包含以广金钱草醇提取物形式提供的广金钱草总黄酮和药学上可接受的赋形剂。
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7.发明公开
公开(公告)号：EP3357925A1
公开(公告)日：2018-08-08
申请号：EP16850379.5
申请日：2016-09-29
申请人： Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. , Humanwell Healthcare (Group) Co., Ltd. , Medshine Discovery Inc.
发明人： WANG, Xuehai , DING, Charles Z. , SHEN, Jie , CHEN, Shuhui , LI, Lie , LI, Gang , XU, Yong , WANG, Cailin , TU, Ronghua , WANG, Jimeng , YUE, Yang , DENG, Biao , CHEN, Hailiang , LIU, Hui , SUN, Wenjie , WANG, Cong , HUANG, Lu , WANG, Zheng , LI, Weidong
IPC分类号： C07D487/04 , C07D401/04 , A61P35/00
CPC分类号： C07D487/04 , C07B2200/13 , C07C57/145 , C07D401/04
摘要： Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof.
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公开(公告)号：EP3246317A1
公开(公告)日：2017-11-22
申请号：EP15877553.6
申请日：2015-06-17
申请人： Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. , Humanwell Healthcare (Group) Co., Ltd.
发明人： WANG, Xuehai , WU, Chengde , XU, Yong , SHEN, Chunli , LI, Li'e , HU, Guoping , YUE, Yang , LI, Jian , GUO, Diliang , SHI, Nengyang , HUANG, Lu , CHEN, Shuhui , TU, Ronghua , YANG, Zhongwen , ZHANG, Xuwen , XIAO, Qiang , TIAN, Hua , YU, Yanping , CHEN, Hailiang , SUN, Wenjie , HE, Zhenyu , SHEN, Jie , YANG, Jing , TANG, Jing , ZHOU, Wen , YU, Jing , ZHANG, Yi , LIU, Quan
IPC分类号： C07D239/04 , C07D239/48 , C07D235/04 , C07D471/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D213/73 , C07D213/74 , A61K31/505 , A61K31/506 , A61K31/5383 , A61P35/00 , A61P35/02
CPC分类号： C07D401/14 , A61K31/366 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/52 , A61K31/5383 , C07C13/04 , C07D213/73 , C07D213/74 , C07D231/54 , C07D235/04 , C07D239/04 , C07D239/48 , C07D251/12 , C07D401/04 , C07D401/12 , C07D471/04
摘要： Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
摘要翻译： 提供了一系列BTK抑制剂，并且具体公开了由式（I），（II），（III）或（IV）表示的化合物，其药学上可接受的盐，其互变异构体或前药。
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9.发明公开DESMODIUM STYRACIFOLIUM (OSB.) MERR. FLAVONOIDS CAPSULE, METHOD OF PREPARING SAME, AND APPLICATION THEREOF 审中-公开DESMODIUM STYRACIFOLIUM（OSB。）MERR。 黄酮胶囊，其制备方法及其应用
公开(公告)号：EP3078380A1
公开(公告)日：2016-10-12
申请号：EP14868261.0
申请日：2014-07-15
申请人： Wuhan Optics Valley Humanwell Bio-pharmaceutical Co. Ltd. , Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. , Wuhan Chemligand Bio-Pharmaceutical Co. Ltd. , Humanwell Healthcare (Group) Co., Ltd.
发明人： WANG, Xuehai , XU, Yong , LI, Li'e , LI, Jie , TU, Ronghua , CHEN, Gang , CAO, Rubin , FENG, Yun , YANG, Zhongwen , FAN, Zhaoze , YU, Yanping , XIAO, Qiang , HUANG, Lu , YANG, Chengbing , HUANG, Tianci , TIAN, Hua , YANG, Jing
CPC分类号： A61K36/48 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1682 , A61K9/4833 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K2236/33 , A61K2236/53
摘要： A capsule containing total flavonoids of Desmodium styracifolium, a method for preparing the same and a use of the capsule containing total flavonoids of Desmodium styracifolium are provided. Specifically, the capsule includes total flavonoids of Desmodium Styracifolium provided in a form of alcohol extract of Desmodium Styracifolium and a pharmaceutically acceptable excipient.
摘要翻译： 提供了含有广金钱草总黄酮的胶囊，其制备方法和使用含有金钱草总黄酮的胶囊。 具体而言，所述胶囊包含以广金钱草醇提取物形式提供的广金钱草总黄酮和药学上可接受的赋形剂。
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