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1.发明公开POLYMER-COATED FINE INORGANIC PARTICLE AND PROCESS FOR PRODUCING THE SAME 有权FEINE ANORGANISCHE POLYMERBESCHICHTETE PARTIKEL UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2221327A1
公开(公告)日：2010-08-25
申请号：EP08865151.8
申请日：2008-12-03
申请人： Handa, Hiroshi , Abe, Masanori , Hatakeyama, Mamoru , Sakamoto, Satoshi , Nishio, Kosuke , Masaike, Yuka , Kishi, Hiroshi
发明人： Handa, Hiroshi , Abe, Masanori , Hatakeyama, Mamoru , Sakamoto, Satoshi , Nishio, Kosuke , Masaike, Yuka , Kishi, Hiroshi
IPC分类号： C08F292/00
CPC分类号： C09C1/42 , B82Y30/00 , C01P2004/03 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2004/84 , C08F2/38 , C08F2/44 , C08F292/00 , C08F293/005 , C08F2438/03 , C08J5/005 , C09C3/12 , C08F220/10 , C08F212/08
摘要： An object of the present invention is to provide a polymer coated magnetic fine polymer by coating an inorganic fine particle with a thin polymer layer under precise control of a polymerization reaction and a method for preparing the same. Onto a surface of the inorganic fine particle the iniferter is fixed and grafted chains are formed on the inorganic fine particle by a living radical polymerization using the iniferter as an initiator which is defined by the following chemical formula:
(wherein X is a hydrophilic atomic group being capable of binding to a surface of the inorganic fine particle, R1 and R2 are each independently selected from a mono-valent hydrocarbyl group which is formed by removing one hydrogen atom from hydrocarbon.)摘要翻译： 本发明的目的在于提供一种聚合物涂覆的磁性微粒聚合物，其通过在聚合反应的精确控制下涂覆具有薄聚合物层的无机细颗粒及其制备方法。 在无机细颗粒的表面上，引发剂是固定的，并且通过使用引发剂作为引发剂的活性自由基聚合在无机细颗粒上形成接枝链，所述引发剂由以下化学式定义：（其中X是亲水性原子团 能够结合无机细颗粒的表面，R 1和R 2各自独立地选自通过从烃除去一个氢原子而形成的一价烃基。）
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2.发明授权Drug-immobilized particles and a process of purifying proteins 失效Wirkstoffimmobilisierte颗粒和过程对于蛋白质的纯化
公开(公告)号：EP0787988B1
公开(公告)日：2004-04-28
申请号：EP97101821.3
申请日：1997-02-05
IPC分类号： G01N33/547 , G01N33/546 , C07K14/705
CPC分类号： C07K14/705 , G01N33/54313 , G01N33/54353 , G01N33/94 , Y10S435/803 , Y10S435/815 , Y10S530/815 , Y10S530/816
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3.发明公开Drug-immobilized particles and a process of purifying proteins 失效Wirkstoffimmobilisierte颗粒和过程对于蛋白质的纯化
公开(公告)号：EP0787988A3
公开(公告)日：2000-10-04
申请号：EP97101821.3
申请日：1997-02-05
IPC分类号： G01N33/547 , G01N33/546 , C07K14/705
CPC分类号： C07K14/705 , G01N33/54313 , G01N33/54353 , G01N33/94 , Y10S435/803 , Y10S435/815 , Y10S530/815 , Y10S530/816
摘要： The invention includes a microsphere comprising styrene-glycidyl methacrylate polymer, and methods for isolation, purification and identification of receptors to a specific compound possessing physiological activity. In addition, the invention provides proteins isolated and purified using the microspheres of the invention.
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公开(公告)号：EP3173476A1
公开(公告)日：2017-05-31
申请号：EP16201293.4
申请日：2016-11-30
发明人： Handa, Hiroshi , Kawano, Masaaki , Kato, Masahiko
CPC分类号： A61K39/39 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/542 , A61K2039/543 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K2319/00 , C07K2319/43 , C12N7/00 , C12N2710/22023 , C12N2710/22034 , C12N2760/16134
摘要： Disclosed is an immunity inducer. The immunity inducer comprises virus like particles; the virus like particles comprise a virus-derived outer coat protein and an antigen-bound protein comprising an exogenous antigen; the outer coat protein constitutes an outer coat of the virus like particles, and the antigen-bound protein is comprised in the outer coat; and the virus like particles induce an immune effect of a living body on the antigen.
摘要翻译： 公开了一种免疫诱导剂。 免疫诱导剂包含病毒样颗粒; 病毒样颗粒包含病毒衍生的外壳蛋白和包含外源抗原的抗原结合蛋白; 外壳蛋白构成病毒样颗粒的外包衣，抗原结合蛋白包含在外包衣中; 并且病毒样颗粒诱导活体对抗原的免疫作用。
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5.发明公开Drug-immobilized particles and a process of purifying proteins 失效Wirkstoffimmobilisierte Partikel und Verfahren zur Reinigung von Proteinen
公开(公告)号：EP0787988A2
公开(公告)日：1997-08-06
申请号：EP97101821.3
申请日：1997-02-05
IPC分类号： G01N33/547 , G01N33/546 , C07K14/705
CPC分类号： C07K14/705 , G01N33/54313 , G01N33/54353 , G01N33/94 , Y10S435/803 , Y10S435/815 , Y10S530/815 , Y10S530/816
摘要： The invention includes a microsphere comprising styrene-glycidyl methacrylate polymer, and methods for isolation, purification and identification of receptors to a specific compound possessing physiological activity. In addition, the invention provides proteins isolated and purified using the microspheres of the invention.
摘要翻译： 本发明包括一种包含苯乙烯 - 甲基丙烯酸缩水甘油酯聚合物的微球，以及用于分离，纯化和鉴定具有生理活性的特定化合物的受体的方法。 此外，本发明提供使用本发明的微球分离和纯化的蛋白质。
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