公开(公告)号：EP1987849A1

公开(公告)日：2008-11-05

申请号：EP07708041.4

申请日：2007-02-05

申请人： Japan Medical Materials Corporations ,  Moro, Toru ,  Ishihara, Kazuhiko ,  Konno, Tomohiro ,  Nakamura, Kozo ,  Takatori, Yoshio ,  Kawaguchi, Hiroshi

发明人： MORO, Toru ,  ISHIHARA, Kazuhiko ,  KONNO, Tomohiro ,  NAKAMURA, Kozo ,  TAKATORI, Yoshio ,  KAWAGUCHI, Hiroshi ,  KYOMOTO, Masayuki ,  TAKADAMA, Hiroaki ,  KONDO, Makoto ,  YAMAWAKI, Noboru ,  NIZUKA, Takeshi ,  HASHIMOTO, Masami

IPC分类号： A61L27/00 ,  A61F2/30

CPC分类号： A61F2/30767 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3662 ,  A61F2/367 ,  A61F2/3676 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4059 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4241 ,  A61F2/4425 ,  A61F2/468 ,  A61F2002/3065 ,  A61F2002/30654 ,  A61F2002/30884 ,  A61F2002/30904 ,  A61F2002/30934 ,  A61F2002/3493 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/3631 ,  A61F2002/3682 ,  A61F2002/4018 ,  A61F2002/4051 ,  A61F2002/4062 ,  A61L27/34 ,  A61L27/50 ,  Y10T428/31913

摘要： The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.

摘要翻译： 本发明提供耐久性优异且能够长时间保持耐磨性的轴承材料。 本发明的轴承材料是用于在潮湿环境下使用的高耐磨轴承材料10，包括：由具有亚甲基的聚合物材料制成的基体12; 以及覆盖基板12的支承面16的聚合物层30，聚合物层30包含具有磷酸胆碱基团并从承载面16接枝的聚合物链，其中滑动面16的磷酸指数为 在滑动面上测定的红外光谱中的亚磷酸基峰的峰值强度不小于0.28。

公开(公告)号：EP1433488A1

公开(公告)日：2004-06-30

申请号：EP03705299.0

申请日：2003-02-19

申请人： KABUSHIKI KAISHA KOBE SEIKO SHO ,  Ishihara, Kazuhiko ,  Nakamura, Azuko

发明人： ISHIHARA, Kazuhiko ,  NAKAMURA, Kozo ,  MORO, Toru ,  TAKATORI, Yoshio ,  KAWAGUCHI, Hiroshi ,  KONNO, Tomohiro ,  MATSUSHITA, Tomiharu, K.K. KOBE SEIKO SHO ,  KUSUMOTO, Shuji, K.K. KOBE SEIKO SHO

IPC分类号： A61L27/14 ,  A61L27/34 ,  A61L27/16 ,  A61F2/30

CPC分类号： A61F2/30 ,  A61F2/30767 ,  A61F2/32 ,  A61F2/34 ,  A61F2/468 ,  A61F2002/30673 ,  A61F2002/30685 ,  A61F2002/30934 ,  A61F2002/3611 ,  A61F2310/00017 ,  A61F2310/00029 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61L27/34 ,  A61L27/50 ,  A61L2430/24 ,  B29K2995/0087 ,  B29L2031/7532 ,  C08L101/02

摘要： An artificial joint member made of a polymeric material including a portion made of a polymeric substance has a sliding surface composed of a polymer having phosphoryl choline groups. With such an arrangement, the artificial joint member is provided with a sliding part capable of keeping a satisfactory lubricating state for a long term.

摘要翻译： 由包含由聚合物制成的部分的聚合材料制成的人造关节构件具有由具有磷酰胆碱基团的聚合物组成的滑动表面。 通过这样的结构，人造接头构件设置有能够长期保持令人满意的润滑状态的滑动部。

公开(公告)号：EP1163905A1

公开(公告)日：2001-12-19

申请号：EP99922593.1

申请日：1999-05-31

申请人： NOF CORPORATION ,  Ishihara, Kazuhiko ,  Nakabayashi, Nobuo

发明人： ISHIHARA, Kazuhiko ,  NAKABAYASHI, Nobuo ,  SHIMADA, Kunio ,  TANAKA, Yukihisa ,  NAKANO, Yoshio

IPC分类号： A61K31/20 ,  A61K47/10 ,  A61K47/30 ,  A61K7/48 ,  A61K35/60 ,  A61K35/78

CPC分类号： A61K8/67 ,  A61K8/8152 ,  A61K8/922 ,  A61K8/925 ,  A61K9/06 ,  A61K31/20 ,  A61K2800/522 ,  A61Q19/00

摘要： Skin external preparation composition applicable to atopic dermatitis, etc. and exhibit little side effect, containing a natural oil and/or fat (A) containing an ω-3 unsaturated fatty acid and an ω-6 unsaturated fatty acid, the content of the ω-3 unsaturated fatty acid being 4 times or more the content of the ω-6 unsaturated fatty acid; a phosphorylcholine-like group containing polymer (B); and an antioxidant (C).

摘要翻译： 含有含有ω-3不饱和脂肪酸和ω-6不饱和脂肪酸的天然油和/或脂肪（A），适用于特应性皮炎等的皮肤外用制剂组合物，并且显示出很小的副作用，ω- -3不饱和脂肪酸是ω-6不饱和脂肪酸含量的4倍以上; 含有磷酸胆碱的基团的聚合物（B）; 和抗氧化剂（C）。

公开(公告)号：EP1759761A4

公开(公告)日：2008-11-05

申请号：EP05741368

申请日：2005-05-18

申请人： SHISEIDO CO LTD ,  ISHIHARA KAZUHIKO

发明人： MAENO KATSUYUKI ,  MIYAZAWA KAZUYUKI ,  ISHIKUBO AKIRA ,  ISHIHARA KAZUHIKO

IPC分类号： G01N33/543 ,  B01D15/38 ,  B01J20/22 ,  B01J20/286 ,  B01J20/32 ,  C07F9/09

CPC分类号： B01J20/286 ,  B01D15/3804 ,  B01J20/28004 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3248 ,  B01J20/3259 ,  B01J20/3274 ,  B01J20/3285 ,  B01J2220/58 ,  C07F9/091 ,  G01N33/54393

摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.

公开(公告)号：EP1433488B1

公开(公告)日：2010-11-03

申请号：EP03705299.0

申请日：2003-02-19

申请人： KABUSHIKI KAISHA KOBE SEIKO SHO ,  Ishihara, Kazuhiko ,  Nakamura, Kozo ,  Takatori, Yoshio ,  Kawaguchi, Hiroshi ,  Moro, Toru

发明人： ISHIHARA, Kazuhiko ,  NAKAMURA, Kozo ,  MORO, Toru ,  TAKATORI, Yoshio ,  KAWAGUCHI, Hiroshi ,  KONNO, Tomohiro ,  MATSUSHITA, Tomiharu, K.K. KOBE SEIKO SHO ,  KUSUMOTO, Shuji, K.K. KOBE SEIKO SHO

IPC分类号： A61L27/14 ,  A61L27/34 ,  A61L27/16 ,  A61F2/30

CPC分类号： A61F2/30 ,  A61F2/30767 ,  A61F2/32 ,  A61F2/34 ,  A61F2/468 ,  A61F2002/30673 ,  A61F2002/30685 ,  A61F2002/30934 ,  A61F2002/3611 ,  A61F2310/00017 ,  A61F2310/00029 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61L27/34 ,  A61L27/50 ,  A61L2430/24 ,  B29K2995/0087 ,  B29L2031/7532 ,  C08L101/02

摘要： An artificial joint member made of polymeric materials, wherein a surface layer of the sliding part is made of a polymer having phosphorylcholine groups. Thus, the sliding part can retain a satisfactory lubricated state over long.

公开(公告)号：EP1095665B1

公开(公告)日：2008-09-03

申请号：EP99926945.9

申请日：1999-07-06

申请人： NOF CORPORATION ,  Nakabayashi, Nobuo ,  Ishihara, Kazuhiko

发明人： NAKABAYASHI, Nobuo ,  ISHIHARA, Kazuhiko ,  TANAKA, Shinji ,  SUZUKI, Ken ,  SHUTO, Kenshiro ,  HAYASHI, Akio

IPC分类号： A61L15/00 ,  C08F30/02 ,  C08F290/06

CPC分类号： C08F230/02 ,  A61L15/24 ,  A61L15/26 ,  A61L27/16 ,  C08F30/02 ,  C08L43/02 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F2222/1013 ,  C08F2220/1858 ,  C08F2220/325 ,  C08L101/02

摘要： A wound-covering preparation containing a polymer having a group represented by formula (I) (wherein R?1, R2, and R3¿ are the same or different and each represents hydrogen or C¿1-4? alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a patient with the wound-covering material to protect the wound.

公开(公告)号：EP0767212B1

公开(公告)日：2001-07-18

申请号：EP96907752.8

申请日：1996-04-02

申请人： NOF CORPORATION ,  Japan Science and Technology Corporation ,  Nakabayashi, Nobuo ,  Ishihara, Kazuhiko

发明人： NAKABAYASHI, Nobuo ,  ISHIHARA, Kazuhiko ,  SHUTO, Kenshiro ,  MATSUYAMA, Kazuo

IPC分类号： C08L43/02 ,  C08F6/06 ,  C08F30/02

CPC分类号： C08F6/06 ,  C08F6/003 ,  C08F30/02

摘要： A process for producing an aqueous solution of a phosphorylcholine group bearing polymer, comprising polymerizing a polymerizable composition containing a phosphorylcholine group bearing monomer of general formula (1) in the presence of a nonmetallic polymerization initiator soluble in a water-containing medium to obtain a crude aqueous solution of a polymer and purifying the solution by the use of a separation membrane; and an aqueous solution of a phosphorycholine group bearing polymer produced by this process and having an impurity content of 2000 ppm. or below (X: a divalent organic residue; Y: C1-C6 alkyleneoxy; Z: H or R -O-CO- (R : C1-C10 alkyl or C1-C10 hydroxyalkyl); R : H or CH3; R , R and R : H, C1-C6 hydrocarbyl or hydroxylated hydrocarbyl; and m: 0 or 1).

公开(公告)号：EP1095665A1

公开(公告)日：2001-05-02

申请号：EP99926945.9

申请日：1999-07-06

申请人： NOF CORPORATION ,  Nakabayashi, Nobuo ,  Ishihara, Kazuhiko

发明人： NAKABAYASHI, Nobuo ,  ISHIHARA, Kazuhiko ,  TANAKA, Shinji ,  SUZUKI, Ken ,  SHUTO, Kenshiro ,  HAYASHI, Akio

IPC分类号： A61L15/00 ,  C08F30/02 ,  C08F290/06

CPC分类号： C08F230/02 ,  A61L15/24 ,  A61L15/26 ,  A61L27/16 ,  C08F30/02 ,  C08L43/02 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F2222/1013 ,  C08F2220/1858 ,  C08F2220/325 ,  C08L101/02

摘要： A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R 1 , R 2 and R 3 are the same or different and each represents hydrogen atom or C 1-4 alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.

公开(公告)号：EP0947244A1

公开(公告)日：1999-10-06

申请号：EP97933843.1

申请日：1997-07-30

申请人： NOF CORPORATION ,  Japan Science and Technology Corporation ,  Nakabayashi, Nobuo ,  Ishihara, Kazuhiko

发明人： NAKABAYASHI, Nobuo ,  ISHIHARA, Kazuhiko ,  SHIINO, Daijiro ,  WAKI, Kazunori

IPC分类号： B01F17/52 ,  C08L101/06 ,  C08L43/02 ,  C08F230/02 ,  C11D3/37 ,  C11D1/78

CPC分类号： C08F30/02 ,  A61K8/04 ,  A61K8/06 ,  A61K8/553 ,  A61K8/8152 ,  A61K9/0014 ,  A61K47/32 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/10 ,  B01F17/005 ,  B01F17/0064

摘要： Solubilizers, emulsifiers and dispersing agents having the effects of moisturizing the skin when used as washing agents and having the character of elevating the concentration of a material to be solubilized, emulsified or dispersed in solvents including water as compared with the case where the material is employed alone, or elevating the apparent concentration of a material to be emulsified or dispersed in solvents by increasing homogeneity of the emulsion or dispersion which contain as the active ingredient polymers obtained by polymerizing monomer compositions containing at least one hydrophilic monomer (a) having a group represented by general formula (1) in the side chain, wherein R 1 , R 2 and R 3 represent each H or C1-4 alkyl.

摘要翻译： 与作为洗涤剂一起使用时具有保湿皮肤作用的增溶剂，乳化剂和分散剂相比，​​与使用该材料的情况相比，具有将要溶解，乳化或分散在包括水的溶剂中的物质的浓度提高的特征 或通过增加包含作为活性成分的乳液或分散体的均匀性来提高待乳化或分散在溶剂中的材料的表观浓度，所述乳液或分散体含有通过聚合含有至少一种所表示的基团的亲水性单体（a）的单体组合物而获得的聚合物 由侧链中的通式（1）表示，其中R 1，R 2和R 3表示每个H或C 1-4烷基。

公开(公告)号：EP1987849B1

公开(公告)日：2016-11-23

申请号：EP07708041.4

申请日：2007-02-05

申请人： Kyocera Medical Corporation ,  Moro, Toru ,  Ishihara, Kazuhiko ,  Nakamura, Kozo ,  Takatori, Yoshio ,  Kawaguchi, Hiroshi

发明人： MORO, Toru ,  ISHIHARA, Kazuhiko ,  KONNO, Tomohiro ,  NAKAMURA, Kozo ,  TAKATORI, Yoshio ,  KAWAGUCHI, Hiroshi ,  KYOMOTO, Masayuki ,  TAKADAMA, Hiroaki ,  KONDO, Makoto ,  YAMAWAKI, Noboru ,  NIZUKA, Takeshi ,  HASHIMOTO, Masami

IPC分类号： A61L27/34 ,  A61L27/50 ,  A61F2/30 ,  A61F2/46

CPC分类号： A61F2/30767 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3662 ,  A61F2/367 ,  A61F2/3676 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4059 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/4241 ,  A61F2/4425 ,  A61F2/468 ,  A61F2002/3065 ,  A61F2002/30654 ,  A61F2002/30884 ,  A61F2002/30904 ,  A61F2002/30934 ,  A61F2002/3493 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/3631 ,  A61F2002/3682 ,  A61F2002/4018 ,  A61F2002/4051 ,  A61F2002/4062 ,  A61L27/34 ,  A61L27/50 ,  Y10T428/31913