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    IMMUNE RECOGNITION MOTIFS
    1.
    发明公开
    IMMUNE RECOGNITION MOTIFS 审中-公开
    免疫识别MOTIFS

    公开(公告)号：EP3167396A2

    公开(公告)日：2017-05-17

    申请号：EP15818218.8

    申请日：2015-07-10

    申请人： Iogenetics, LLC.

    发明人： BREMEL, Robert D. ,  HOMAN, Jane ,  IMBODEN, Michael

    IPC分类号： G06F19/18 ,  G06F19/24 ,  G06N3/08

    CPC分类号： G06F19/22 ,  G01N33/6854 ,  G01N33/6878 ,  G01N2800/24 ,  G06F19/18 ,  G06F19/28

    摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.

    摘要翻译： 本发明提供了用于鉴定和分类表位以及使用该信息分析蛋白质中的蛋白质和肽，特别是潜在表位，并使用该信息设计合成肽和蛋白质，分析生物药物蛋白质并诊断自身免疫病症的方法和系统。 结合在MHC凹槽中的肽包含两组氨基酸：面向内凹槽并确定对MHC分子（凹槽暴露的基序或GEM）的结合亲和力的那些氨基酸以及不与凹槽相互作用的那些氨基酸，而是 在正面暴露于T细胞（T细胞暴露的基序或TCEM）。 本发明利用与GEM和TCEM的身份和生理化学特征相关的信息。

    IMMUNE RECOGNITION MOTIFS
    2.
    发明公开
    IMMUNE RECOGNITION MOTIFS 审中-实审

    公开(公告)号：EP4379725A2

    公开(公告)日：2024-06-05

    申请号：EP24152024.6

    申请日：2015-07-10

    申请人： Iogenetics, LLC.

    发明人： BREMEL, Robert D. ,  HOMAN, Jane ,  IMBODEN, Michael

    IPC分类号： G16B20/50

    CPC分类号： G01N33/6854 ,  G01N2800/2420130101 ,  G16B30/00 ,  G16B20/00 ,  G16B50/00 ,  G16B20/30 ,  G16B20/50

    摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.

    IMMUNE RECOGNITION MOTIFS
    4.
    发明公开
    IMMUNE RECOGNITION MOTIFS 审中-公开

    公开(公告)号：EP3167396A4

    公开(公告)日：2018-03-21

    申请号：EP15818218

    申请日：2015-07-10

    申请人： IOGENETICS LLC

    发明人： BREMEL ROBERT D ,  HOMAN JANE ,  IMBODEN MICHAEL

    IPC分类号： G06F19/18 ,  G06F19/24 ,  G06N3/08

    CPC分类号： G06F19/22 ,  G01N33/6854 ,  G01N33/6878 ,  G01N2800/24 ,  G06F19/18 ,  G06F19/28

    摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.