-
1.发明公开A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE TRUNK (EXCEPT CHEST) AND EXTREMITIES WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) 审中-公开用异丙醇3-（3,5-二乙基恶唑-4-羧酸酯）局部治疗子宫颈上的吉西他斯（不包括胸腺）
公开(公告)号：EP3223814A1
公开(公告)日：2017-10-04
申请号：EP15808551.4
申请日：2015-11-27
CPC分类号： A61K31/42 , A61K9/0014 , A61K9/06 , A61K31/41
摘要： The invention relates to the treatment of actinic keratosis on the trunk (except chest) and extremities with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).
摘要翻译： 本发明涉及用巨大戟二萜醇3-（3,5-二乙基异恶唑-4-羧酸酯）治疗躯干（胸部除外）和四肢的光化性角化病。
-
2.发明公开A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE SCALP WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) 审中-公开3-（3,5-二乙基恶唑-4-羧酸甲酯）用于局部治疗鳞癌上吉西他滨的方法
公开(公告)号：EP3223813A1
公开(公告)日：2017-10-04
申请号：EP15801810.1
申请日：2015-11-27
CPC分类号： A61K31/235 , A61K31/4025 , A61K31/41 , A61K31/55 , C07D273/01 , C07D521/00
摘要： The invention relates to the treatment of actinic keratosis on the scalp with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).
摘要翻译： 本发明涉及用巨大戟二萜醇3-（3,5-二乙基异恶唑-4-甲酸酯）治疗头皮上的光化性角化病。
-
3.发明公开A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE FULL FACE OR 250 CM2 ON THE CHEST WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) 审中-公开用3-（3,5-二乙基恶唑-4-羧酸甲酯）制备胸腺全面或250厘米2甲状腺局部吉西他斯的方法
公开(公告)号：EP3223812A1
公开(公告)日：2017-10-04
申请号：EP15801809.3
申请日：2015-11-27
CPC分类号： A61K31/42 , A61K9/0014 , A61K9/06 , A61K31/41
摘要： The invention relates to the treatment of actinic keratosis on the full face or 250 cm2 on the chest with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).
摘要翻译： 本发明涉及用巨大戟二萜醇3-（3,5-二乙基异恶唑-4-羧酸酯）治疗全脸或250cm 2胸部光化性角化病。
-
4.发明公开A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) 审中-公开方法用于局部治疗光化性角化病的巨大戟二萜3-（3,5- DIETHYLISOXAZOL -4-羧酸乙酯）
公开(公告)号：EP3060304A1
公开(公告)日：2016-08-31
申请号：EP14838790.5
申请日：2014-10-27
发明人： SELMER, Johan , KNUDSEN, Kim, Mark
IPC分类号： A61P17/00
CPC分类号： A61K31/422 , A61K9/0014 , A61K9/06 , A61K31/41 , A61K31/4155
摘要： The invention relates to the topical treatment of actinic keratosis with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).
摘要翻译： 本发明涉及巨大戟二萜与3-（3,5- diethylisoxazole -4-羧酸乙酯）光化性角化病的局部治疗。
-
5.发明公开INGENOL MEBUTATE IN COMBINATION WITH LASER THERAPY FOR THE TREATMENT OF HYPERKERATOTIC SKIN LESIONS 审中-公开巨大戟甲基丁烯酸酯 - 激光治疗中，治疗角化过度性皮肤病联合
公开(公告)号：EP2981257A1
公开(公告)日：2016-02-10
申请号：EP14717429.6
申请日：2014-04-02
IPC分类号： A61K31/222 , A61P17/12 , A61N5/067
CPC分类号： A61B18/20 , A61B18/203 , A61B2018/00452 , A61B2018/00577 , A61K9/0014 , A61K9/06 , A61K31/22
摘要： The invention relates to the treatment of actinic keratosis (AK) lesions using laser therapy followed by treatment with ingenol mebutate (e.g., PEP005 Gel).
-
公开(公告)号：EP2931250A1
公开(公告)日：2015-10-21
申请号：EP13805343.4
申请日：2013-12-11
CPC分类号： A61K31/22 , A61K9/0014 , A61K9/06 , A61K9/127 , A61K9/1272
摘要： Aqueous topical liposome gel compositions comprising ingenol-3-angelate.
摘要翻译： 包含巨大戟二萜醇-3-当归酸酯的含水局部用脂质体凝胶组合物。
-
7.发明公开A TOPICAL GEL COMPOSITION COMPRISING AN INGENOL DERIVATIVE AND A SOLVENT MIXTURE 审中-公开WITH A INGENOLDERIVAT - 混合溶剂外用凝胶剂组合物
公开(公告)号：EP2858629A1
公开(公告)日：2015-04-15
申请号：EP13729652.1
申请日：2013-06-07
摘要： A substantially anhydrous pharmaceutical gel composition for cutaneous application comprising an ingenol derivative in dissolved or solubilized form, a solvent mixture of (a) a hydrophilic non-ionic surfactant; (b) a lipophilic non-ionic co-surfactant; (c) an oil; the composition further comprising an acidic compound, a co-solvent, a viscosity-increasing agent and a pharmaceutically acceptable, substantially anhydrous, non-solvent lipid carrier.
-
公开(公告)号：EP1296698B1
公开(公告)日：2015-01-14
申请号：EP01937873.6
申请日：2001-06-07
IPC分类号： A61P29/00 , A61K31/455 , A61K31/22 , A61P31/02 , G06F19/00 , A61P31/18 , A61K36/47 , A61P31/04 , A61P33/10
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating. the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
-
9.发明公开A TOPICAL COMPOSITION COMPRISING AN INGENOL DERIVATIVE AND A SURFACTANT-COSOLVENT MIXTURE 审中-公开WITH A INGENOLDERIVAT和共溶剂 - 表面活性剂混合物局部组合物
公开(公告)号：EP2790694A1
公开(公告)日：2014-10-22
申请号：EP12818612.9
申请日：2012-12-12
CPC分类号： A61K47/10 , A61K9/0014 , A61K9/107 , A61K31/22 , A61K47/44
摘要： A topical composition for cutaneous application which is a water-in-oil emulsion comprises an oily phase comprising (a) an ingenol derivative in dissolved form; (b) at least one non-ionic surfactant selected from the group consisting of polyoxyl glycerides, polyoxyethylene castor oil derivatives, polyoxyethylene alkyl ethers, polysorbates,or a mixture of acrylamide acryloyldimethyl taurate copolymer, isohexadecane and polysorbate 80, sterols, fatty alcohols, fatty acid phosphonates, mono- or diglycol esters, mono- di- or polyglyceryl esters, mono-, di- or plyglucose esters, sucrose esters or sorbitan esters, the non-ionic surfactant being present in an amount of from about 0.5% by weight to about 10% by weight of the composition; (c) a solvent for the ingenol derivative; and an aqueous phase buffered to a pH of 2.6-3.7.
-
公开(公告)号：EP2790671A1
公开(公告)日：2014-10-22
申请号：EP12818613.7
申请日：2012-12-12
CPC分类号： A61K31/22 , A61K9/0014 , A61K9/06 , A61K31/122 , A61K31/215 , A61K31/222 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/38 , A61K47/44
摘要： Topical gel compositions comprising ingenol-3-angelate, wherein less than 10% of the ingenol-3-angelate degrades when the gel is stored for 2 years at 25°C.
摘要翻译： 包含巨大戟二萜醇-3-当归酸酯的局部凝胶组合物，其中当凝胶在25℃储存2年时，小于10％的巨大戟二萜醇-3-当归酯降解。
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.02 秒)
