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    METHODS AND COMPOSITIONS FOR HEMATOXYLIN AND EOSIN STAINING
    6.
    发明公开
    METHODS AND COMPOSITIONS FOR HEMATOXYLIN AND EOSIN STAINING 有权
    VERFAHRENFÜRHÄMATOXYLIN-UNDEOSINANFÄRBUNG

    公开(公告)号：EP2807490A1

    公开(公告)日：2014-12-03

    申请号：EP13702719.9

    申请日：2013-01-25

    申请人： Leica Biosystems Richmond, Inc.

    发明人： HANSEN, Stanley E. ,  MYERS, Russell ,  PAUL, Ronald ,  RASMUSSEN, Audra ,  TAYLOR, Kate

    IPC分类号： G01N33/68

    CPC分类号： G01N1/30 ,  G01N33/6839 ,  G01N2001/302

    摘要： The present invention provides for solutions of a defined composition useful in a staining protocol, such as a hematoxylin and eosin staining protocol, when used at certain points of the staining protocol. The formulations of these defined solutions are such that carry-over of the solutions will not negatively impact, or preferably, will stabilize or favorably modify staining reagent solutions coming in contact with the solutions. In certain embodiments of the invention, solutions are buffered to maintain a specific pH that when carried-over-such as carried-over into hematoxylin--will not significantly influence the pH of the next staining reagent.

    摘要翻译： 当在染色方案的某些点使用时，本发明提供了可用于染色方案中的限定的组合物的溶液，例如苏木精和伊红染色方案。 这些定义的溶液的制剂使得溶液的转移不会对该溶液接触的染色试剂溶液产生负面影响，或者优选地稳定或有利地修饰染色试剂溶液。 在本发明的某些实施方案中，缓冲溶液以保持特定的pH值，当被携带 - 例如携带到苏木精中时 - 不会显着影响下一个染色试剂的pH。

    Apparatus and method for histological processing of a tissue specimen with means for maintaining the orientation of the specimen throughout the processing
    8.
    发明公开
    Apparatus and method for histological processing of a tissue specimen with means for maintaining the orientation of the specimen throughout the processing 审中-公开
    装置和方法的装置的组织样品的组织学处理的整个处理过程中保持所述样品的取向

    公开(公告)号：EP2420813A2

    公开(公告)日：2012-02-22

    申请号：EP11001938.7

    申请日：2005-11-29

    申请人： Leica Biosystems Richmond, Inc.

    发明人： McCormick, James

    IPC分类号： G01N1/31 ,  G01N1/36

    CPC分类号： G01N1/36 ,  G01N1/31 ,  G01N1/312 ,  G01N2001/366 ,  Y10T436/2575

    摘要： The present invention is directed to a system for use in the preparation in situ of tissue specimens for histological examination. The system includes a cassette, a specimen mounting card and a base mold. The invention also is directed to a method of processing a tissue sample for histological examination which does not require re-orienting the selected cutting plane in the specimen transfer step. lnstead, the tissue sample remains oriented in a desired position throughout processing.

    摘要翻译： 本发明涉及一种系统，用于在原位组织标本进行组织学检查的制备中的用途。 该系统包括一个带盒，一个样品安装卡和基体模型。 因此，本发明涉及处理用于组织学检查，其不需要重新定向在试样转印步骤所选择的切割平面的组织样品的方法。 lnstead，组织样品保持在所需的整个处理的位置定向。

    MICROTOME AND METHOD OF REVERSIBLY ALTERING A MICROTOME
    9.
    发明授权
    MICROTOME AND METHOD OF REVERSIBLY ALTERING A MICROTOME 有权

    公开(公告)号：EP1993791B1

    公开(公告)日：2018-12-12

    申请号：EP07763122.4

    申请日：2007-02-02

    申请人： Leica Biosystems Richmond, Inc.

    发明人： MCCORMICK, James B.

    IPC分类号： G01N1/06

    CPC分类号： G01N1/06 ,  Y10T29/49998 ,  Y10T83/04 ,  Y10T83/18 ,  Y10T83/202 ,  Y10T83/7487 ,  Y10T83/929

    摘要： A microtome includes a histological cassette support member that is adapted and configured to allow the microtome to be used in connection with relatively thin histological cassettes. A method of reversibly altering a microtome for use with different size histological specimen cassettes includes exchanging the cassette support member of the cassette holding assembly of the microtome with another cassette support member without altering other portions of the cassette holding assembly. A method is also disclosed that includes providing a microtome comprising a first histological tissue cassette clamp, providing a second histological tissue cassette clamp, securing the second histological tissue cassette clamp to the microtome via the first histological tissue cassette clamp, and securing a histological tissue cassette to the microtome via the second histological tissue cassette clamp when the second histological tissue cassette clamp is secured to the microtome via the first histological tissue cassette clamp.

    KIT FOR HEMATOXYLIN AND EOSIN STAINING
    10.
    发明公开
    KIT FOR HEMATOXYLIN AND EOSIN STAINING 审中-公开
    血凝素和EOSIN染色试剂盒

    公开(公告)号：EP3264095A1

    公开(公告)日：2018-01-03

    申请号：EP17181088.0

    申请日：2013-01-25

    申请人： Leica Biosystems Richmond, Inc.

    发明人： HANSEN, Stanley, E. ,  MYERS, Russell ,  PAUL, Ronald ,  RASMUSSEN, Audra ,  TAYLOR, Kate

    IPC分类号： G01N33/68

    摘要： The present invention provide for solutions of a defined composition useful in a staining protocol, such as a hematoxylin and eosin staining protocol, when used at certain points of the staining protocol. The formulations of these defined solutions are such that carry-over of the solutions will not negatively impact, or preferably, will stabilize or favorably modify staining reagent solutions coming in contact with the solutions. In certain embodiments of the invention, solutions are buffered to maintain a specific pH that when carried-over-such as carried-over into hematoxylin-will not significantly influence the pH of the next staining reagent.

    摘要翻译： 当在染色方案的某些点使用时，本发明提供用于染色方案中的限定组合物的溶液，例如苏木精和曙红染色方案。 这些限定的溶液的配方使得溶液的携带不会不利地影响或优选地稳定或有利地改变与溶液接触的染色试剂溶液。 在本发明的某些实施方案中，将溶液缓冲以保持特定的pH，当其携带时（例如携带入苏木精）不会显着影响下一种染色试剂的pH。