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公开(公告)号：EP2751258B1
公开(公告)日：2019-08-14
申请号：EP12828239.9
申请日：2012-09-02
申请人： Lifenet Health
发明人： QIN, Xiaofei , CHEN, Silvia , CHEN, Jingsong , CLAGETT, James
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公开(公告)号：EP3468630A1
公开(公告)日：2019-04-17
申请号：EP17813939.0
申请日：2017-06-13
申请人： Lifenet Health
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公开(公告)号：EP1148847B1
公开(公告)日：2016-07-13
申请号：EP99966492.3
申请日：1999-12-18
申请人： Lifenet
CPC分类号： A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30143 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/30224 , A61F2002/30261 , A61F2002/30263 , A61F2002/3028 , A61F2002/30329 , A61F2002/30383 , A61F2002/30387 , A61F2002/30492 , A61F2002/30494 , A61F2002/30599 , A61F2002/30604 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30904 , A61F2002/30971 , A61F2210/0004 , A61F2220/0025 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2240/001 , A61F2250/0014 , A61F2250/0063 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00329 , A61L27/02 , A61L27/14 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/40 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L2430/02
摘要： A composite bone graft (1) for implantation in a patient, to methods of making, and using the composite bone graft along with methods for treating patients by implanting the composite bone graft at a site in a patient. The composite bone graft includes two or more connected, discrete, bone portions (2-4), and includes one or more bio-compatible connectors (7) which hold together the discrete bone portions (2-4) to form the composite bone graft (1). The composite bone graft (1) may include one or more textured bone surfaces (14b). The textured surface (14a, 14b) preferably includes a plurality of closely spaced protrusions, preferably closely spaced continuous protrusions. The composite bone graft (1) is useful for repairing bone defects caused by congenital anomaly, disease, or trauma in a patient, for example, for restoring vertical support of the anterior, and/or posterior column. Implantation of the composite bone graft results in improved graft stability, and osteo-induction ability, without a decrease in mechanical strength.
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公开(公告)号：EP2431007A1
公开(公告)日：2012-03-21
申请号：EP10012502.0
申请日：1999-12-18
申请人： Lifenet
CPC分类号： A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30143 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/30224 , A61F2002/30261 , A61F2002/30263 , A61F2002/3028 , A61F2002/30329 , A61F2002/30383 , A61F2002/30387 , A61F2002/30492 , A61F2002/30494 , A61F2002/30599 , A61F2002/30604 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30904 , A61F2002/30971 , A61F2210/0004 , A61F2220/0025 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2240/001 , A61F2250/0014 , A61F2250/0063 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00329 , A61L27/02 , A61L27/14 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/40 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L2430/02
摘要： A composite bone graft (1) for implantation in a patient, to methods of making, and using the composite bone graft along with methods for treating patients by implanting the composite bone graft at a site in a patient. The composite bone graft includes two or more connected, discrete, bone portions (2-4), and includes one or more bio-compatible connectors (7) which hold together the discrete bone portions (2-4) to form the composite bone graft (1). The composite bone graft (1) may include one or more textured bone surfaces (14b). The textured surface (14a, 14b) preferably includes a plurality of closely spaced protrusions, preferably closely spaced continuous protrusions. The composite bone graft (1) is useful for repairing bone defects caused by congenital anomaly, disease, or trauma in a patient, for example, for restoring vertical support of the anterior, and/or posterior column. Implantation of the composite bone graft results in improved graft stability, and osteo-induction ability, without a decrease in mechanical strength.
摘要翻译： 一种复合骨移植物（1）用于植入在患者中，以使得，和使用该复合骨移植物地连同用于通过在患者体内的部位植入复合骨移植物治疗的患者的方法的方法。 复合骨移植物包括两个或多个连接的，离散的，骨部分（2-4），并且包括一个或多个生物兼容的连接器（7），其保持所述离散骨部分一起（2-4）以形成复合骨移植物 （1）。 复合骨移植物（1）可以包括一个或多个有纹理的骨表面（14B）。 有纹理的表面（14A，14B）最好包括紧密间隔的突起的复数，优选紧密间隔的连续突出。 复合骨移植物（1）是用于修复由先天性异常，疾病或创伤的患者中引起的骨缺损，例如，用于恢复垂直支撑的前部和/或后柱的是有用的。 在改进的移植物的稳定性，和骨诱导能力的复合骨移植物的结果的注入，而无需在机械强度的降低。
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公开(公告)号：EP1148847A4
公开(公告)日：2004-12-01
申请号：EP99966492
申请日：1999-12-18
申请人： LIFENET
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/44 , A61L27/36 , A61L27/40 , A61L27/44 , A61L27/46 , A61L27/48
CPC分类号： A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30143 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/30224 , A61F2002/30261 , A61F2002/30263 , A61F2002/3028 , A61F2002/30329 , A61F2002/30383 , A61F2002/30387 , A61F2002/30492 , A61F2002/30494 , A61F2002/30599 , A61F2002/30604 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30904 , A61F2002/30971 , A61F2210/0004 , A61F2220/0025 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2240/001 , A61F2250/0014 , A61F2250/0063 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00329 , A61L27/02 , A61L27/14 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/40 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L2430/02
摘要： A composite bone graft (1) for implantation in a patient, to methods of making, and using the composite bone graft along with methods for treating patients by implanting the composite bone graft at a site in a patient. The composite bone graft includes two or more connected, discrete, bone portions (2-4), and includes one or more bio-compatible connectors (7) which hold together the discrete bone portions (2-4) to form the composite bone graft (1). The composite bone graft (1) may include one or more textured bone surfaces (14b). The textured surface (14a, 14b) preferably includes a plurality of closely spaced protrusions, preferably closely spaced continuous protrusions. The composite bone graft (1) is useful for repairing bone defects caused by congenital anomaly, disease, or trauma in a patient, for example, for restoring vertical support of the anterior, and/or posterior column. Implantation of the composite bone graft results in improved graft stability, and osteo-induction ability, without a decrease in mechanical strength.
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公开(公告)号：EP1148847A1
公开(公告)日：2001-10-31
申请号：EP99966492.3
申请日：1999-12-18
申请人： Lifenet
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30143 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/30224 , A61F2002/30261 , A61F2002/30263 , A61F2002/3028 , A61F2002/30329 , A61F2002/30383 , A61F2002/30387 , A61F2002/30492 , A61F2002/30494 , A61F2002/30599 , A61F2002/30604 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30904 , A61F2002/30971 , A61F2210/0004 , A61F2220/0025 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2240/001 , A61F2250/0014 , A61F2250/0063 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00329 , A61L27/02 , A61L27/14 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/40 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L2430/02
摘要： A composite bone graft (1) for implantation in a patient, to methods of making, and using the composite bone graft along with methods for treating patients by implanting the composite bone graft at a site in a patient. The composite bone graft includes two or more connected, discrete, bone portions (2-4), and includes one or more bio-compatible connectors (7) which hold together the discrete bone portions (2-4) to form the composite bone graft (1). The composite bone graft (1) may include one or more textured bone surfaces (14b). The textured surface (14a, 14b) preferably includes a plurality of closely spaced protrusions, preferably closely spaced continuous protrusions. The composite bone graft (1) is useful for repairing bone defects caused by congenital anomaly, disease, or trauma in a patient, for example, for restoring vertical support of the anterior, and/or posterior column. Implantation of the composite bone graft results in improved graft stability, and osteo-induction ability, without a decrease in mechanical strength.
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公开(公告)号：EP3941394A1
公开(公告)日：2022-01-26
申请号：EP20774114.1
申请日：2020-03-20
申请人： Lifenet Health
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公开(公告)号：EP3361987A1
公开(公告)日：2018-08-22
申请号：EP16856276.7
申请日：2016-10-14
申请人： Lifenet Health
发明人： CHEN, Jingsong , JONES, Joshua , BOCKES, Kent , GARRETTSON, John , BRAME, Arthur, L. , SANDER, Thomas , INSKEEP, Beau , DORFMAN, Amy
IPC分类号： A61F2/02
CPC分类号： A61F2/0077 , A61F2/0095 , A61F2/08 , A61F2/12 , A61F2002/0081 , A61F2002/0086 , A61F2210/0004 , A61F2210/0057 , A61F2210/0076 , A61F2230/0013 , A61F2230/0028 , A61F2230/0034 , A61F2230/0041 , A61F2230/0043 , A61F2240/00 , A61F2240/004 , A61L27/3691 , A61L27/502 , A61L2430/34 , A61L2430/40
摘要： Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.
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公开(公告)号：EP3302509A1
公开(公告)日：2018-04-11
申请号：EP16804134.1
申请日：2016-05-27
申请人： Lifenet Health
发明人： FRANCIS, Michael , CHEN, Silvia , BREATHWAITE, Erick , RODRIGUEZ, Rudy , SMITH, Alan , HUBER, Alexander , LEE, Jung, Bok
CPC分类号： C12N5/0068 , C12N5/0605 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/305 , C12N2501/31 , C12N2509/00 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.
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公开(公告)号：EP3256070A1
公开(公告)日：2017-12-20
申请号：EP16749720.5
申请日：2016-02-09
申请人： Lifenet Health
发明人： QIN, Xiaofei , CHEN, Silvia
IPC分类号： A61F2/02
CPC分类号： C12N5/0068 , A61F2/02 , A61L27/3604 , A61L27/3687 , C12N2533/90
摘要： The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.
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