公开(公告)号：EP1253823A4

公开(公告)日：2005-07-20

申请号：EP00989488

申请日：2000-12-27

申请人： LIU CHENGYU

发明人： LIU CHENGYU ,  COSTANTINI FRANKLIN ,  WANG JIN

IPC分类号： A01H1/00 ,  A01K67/027 ,  A01K67/033 ,  C12N9/12 ,  C12N15/09 ,  C12N15/85 ,  A01K67/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12N15/87

CPC分类号： C12N9/1211 ,  A01K2217/05 ,  A01K2267/02 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2830/00

摘要： A method for controlling the sex ratio of offspring by targeting transgenes. The method involves: (a) selecting or creating a transgene whose expression can interfere with sperm's ability to undergo fertilization, and whose gene products (mRNA and protein) do not diffuse freely among inter-connected spermatids; (b) placing the transgene under the regulatory control of post-meiotic spermatogenesis-specific promoter; and (c) using the transgene to generate transgenic animals in the way that the transgene is inserted onto one of the two sex chromosomes.

公开(公告)号：EP1253823A1

公开(公告)日：2002-11-06

申请号：EP00989488.2

申请日：2000-12-27

申请人： Liu, Chengyu

发明人： LIU, Chengyu ,  COSTANTINI, Franklin ,  WANG, Jin

IPC分类号： A01K67/00 ,  A01K67/033 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12N15/87

CPC分类号： C12N9/1211 ,  A01K2217/05 ,  A01K2267/02 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2830/00

摘要： A method for controlling the sex ratio of offspring by targeting transgenes. The method involves: (a) selecting or creating a transgene whose expression can interfere with sperm's ability to undergo fertilization, and whose gene products (mRNA and protein) do not diffuse freely among inter-connected spermatids; (b) placing the transgene under the regulatory control of post-meiotic spermatogenesis-specific promoter; and (c) using the transgene to generate transgenic animals in the way that the transgene is inserted onto one of the two sex chromosomes.