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    TORSIONALLY COMPENSATED GUIDEWIRE
    1.
    发明授权
    TORSIONALLY COMPENSATED GUIDEWIRE 有权
    扭补偿导丝

    公开(公告)号：EP1326528B1

    公开(公告)日：2011-05-04

    申请号：EP01979991.5

    申请日：2001-10-11

    申请人： Micro Therapeutics, Inc.

    发明人： STRAUSS, Brian, M. ,  CONNER, Amanda, M. ,  PERALTA, Nelson

    IPC分类号： A61B5/00 ,  A61M25/09

    CPC分类号： A61M25/09 ,  A61M2025/09083

    摘要： The guidewire includes a core (12) and a coil (18) in composite cooperation to enable the guidewire (10) to be used within tortuous regions of the vasculature. The core (12) has a proximal region (14) and a distal region (16). The distal region (16) includes a flattened end (32) and a tang (36) for connecting the core (12) to the coil. The coil (18) has a proximal end, a distal end and a length extending between the proximal end and the distal end. The ratio between the proximal region and the coil diameter is 1.4:1 or greater. The guidewire includes three joints for attaching the coil to the core. A distal joint (30) attaches the distal end of the coil to the flattened end (32) of the core (12). A proximal joint attaches proximal end of the coil (18) to the core (12). A medial joint attaches the length of the coil to the tang. The three joints cooperate with the 1.4:1 ratio to improve torque transmission ability of the guidewire (10) to enable the guidewire to steer through vessels with bends of over 90 degrees and with lumen diameters of less than 3 mm.

    METHODS AND APPARATUS FOR FLOW RESTORATION
    2.
    发明公开
    METHODS AND APPARATUS FOR FLOW RESTORATION 有权
    VORRICHTUNG ZUR FLUSSWIEDERHERSTELLUNG

    公开(公告)号：EP2254485A1

    公开(公告)日：2010-12-01

    申请号：EP09711843.4

    申请日：2009-02-20

    申请人： Micro Therapeutics, Inc.

    发明人： SLEE, Earl Howard ,  WILDER, Thomas, III. ,  MCCARTHY, Thomas ,  FRANCO, David ,  ASHBY, Mark Philip ,  SHRIVASTAVA, Sanjay

    IPC分类号： A61B17/22

    CPC分类号： A61B17/221 ,  A61B17/22 ,  A61B2017/22034 ,  A61B2017/22094 ,  A61B2017/2215 ,  A61F2/90 ,  A61F2/91 ,  A61F2/92

    摘要： Methods for restoring blood flow in occluded blood vessels using an apparatus having a self expandable distal segment that is pre-formed to assume a superimposed structure in an unconstrained condition but can be made to take on a volume-reduced form making it possible to introduce it with a microcatheter and a push wire arranged at the proximal end, with the distal segment in its superimposed structure assuming the form of a longitudinally open tube and having a mesh structure of interconnected strings or filaments or struts. In a preferred embodiment, the distal segment has a tapering structure at its proximal end where the strings or filaments or struts converge at a connection point.

    摘要翻译： 使用具有预先形成为以无约束状态呈现叠加结构的自扩张远侧段的装置来恢复闭塞血管中的血液流动的方法，但可以进行体积减小的形式，使得可以将其引入 具有布置在近端的微导管和推动线，远端段以其叠加结构呈现纵向开放管的形式，并且具有互连的线或丝或支柱的网状结构。 在优选实施例中，远端段在其近端处具有锥形结构，其中弦或细丝或支柱在连接点处会聚。

    FLOW DIRECTED CATHETER
    5.
    发明授权
    FLOW DIRECTED CATHETER 有权
    FLOW引导穿刺

    公开(公告)号：EP1075297B1

    公开(公告)日：2009-03-18

    申请号：EP99922761.4

    申请日：1999-04-28

    申请人： Micro Therapeutics, Inc.

    发明人： CHOW, Sean, L.

    IPC分类号： A61M25/00 ,  A61M25/01

    CPC分类号： A61M25/0125 ,  A61M25/0012 ,  A61M25/0045 ,  A61M25/0053 ,  A61M25/0054 ,  A61M2025/0042

    摘要： A flow directed microcatheter (10) is formed having a gradually changing flexibility and diameter between a proximal end (A) and a distal end (B) of the microcatheter (10). The changing properties of the microcatheter (10) according to the present invention provide the flexibility of the distal tip (44) needed to allow the microcatheter (10) to be directed by the flow of blood within the vasculature, the columnar strength and torquability at the proximal end (A) and along the length of the microcatheter (10) needed to advance, and direct the distal tip to the target site. A proximal segment (A) of the microcatheter (10) includes a plurality of strands which vary in diameter to change the flexibility of the microcatheter (10). A distal segment (B) of the microcatheter (10) includes an inner layer (46) which is compatible with solvents, such as DMSO, and an outer layer (48) which provides strength and flexibility. The proximal segment (A), and the distal segment (B) of the microcatheter (10) are joined by a kink resistant fuse joint (12).

    Gynecological embolization
    7.
    发明公开
    Gynecological embolization 审中-公开
    Gynäkologische栓塞

    公开(公告)号：EP1625871A1

    公开(公告)日：2006-02-15

    申请号：EP05110823.1

    申请日：1999-02-26

    申请人： MICRO THERAPEUTICS, INC.

    发明人： GREFF, Richard J.

    IPC分类号： A61M37/00 ,  A61B17/42 ,  A61L24/00

    CPC分类号： A61B17/42 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/4216 ,  A61L24/001 ,  A61L24/02 ,  A61L24/06 ,  A61L31/18 ,  A61L2430/36 ,  A61M31/005 ,  C08L29/04

    摘要： This invention is directed to novel methods for gynecologic embolotherapy. The methods directly access the blood vessels to be embolized transcervically rather than arterially. The methods provide precise directed delivery of embolizing compositions, and are particularly suited for treating uterine fibroids. Kits containing one or more devices for transcervical injection and an embolizing composition are also provided. In a preferred embodiment, fluid embolizing compositions are used. In a more preferred embodiment, these fluid embolic compositions comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble constrast agent. In a most preferred embodiment, the contrast agent is characterized by having an average particle size of about 10 µm or less.

    摘要翻译： 本发明涉及妇科膀胱治疗的新方法。 该方法直接进入血管以栓塞栓塞，而不是动脉栓塞。 所述方法提供栓塞组合物的精确定向递送，并且特别适用于治疗子宫肌瘤。 还提供了包含一个或多个用于子宫颈内注射的装置和栓塞组合物的套件。 在优选的实施方案中，使用流体栓塞组合物。 在更优选的实施方案中，这些流体栓塞组合物包含生物相容性聚合物，生物相容性溶剂和生物相容性水不溶性对比剂。 在最优选的实施方案中，造影剂的特征在于具有约10μm或更小的平均粒度。