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公开(公告)号：EP0847240A4
公开(公告)日：2000-01-19
申请号：EP96925568
申请日：1996-07-29
发明人： GREFF RICHARD J , JONES MICHAEL L , EVANS SCOTT
IPC分类号： A61K49/00 , A61K31/00 , A61K31/745 , A61K31/765 , A61K31/78 , A61K31/80 , A61K47/48 , A61K49/04 , A61L24/00 , A61L24/04 , A61L24/06 , A61L24/08 , A61P9/00 , A61P41/00 , A61L25/00 , A61L27/00 , A61L31/00
CPC分类号： A61L24/08 , A61K49/0414 , A61K49/0419 , A61L24/001 , A61L24/046 , A61L24/06 , A61L2430/36 , C08L29/04 , C08L1/26
摘要： Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent characterized by having an average particle size of less than about 10 mu m. In another embodiment, the biocompatible polymer in these compositions is replaced with a biocompatible prepolymer.
摘要翻译： 公开了用于栓塞血管的新型组合物，其特别适用于通过导管递送治疗血管病变。 在一个实施方案中，本发明的组合物包含生物相容性聚合物，生物相容性溶剂和生物相容性水不溶性造影剂，其特征在于具有小于约10μm的平均粒度。 在另一个实施方案中，这些组合物中的生物相容性聚合物被生物相容性预聚物代替。
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公开(公告)号：EP1399213A4
公开(公告)日：2008-03-19
申请号：EP01918177
申请日：2001-03-08
发明人： WHALEN THOMAS J II , GREFF RICHARD J , GILMARTIN KEVIN P , HAYMAN DOUGLAS RAY , HEWITT TODD J , OLSEN ED L , PECOR MARK A , SLEE EARL H , WALLACE GEORGE
CPC分类号： A61F2/958 , A61B17/00491 , A61B17/12022 , A61B17/12118 , A61B17/12186 , A61B2017/00495 , A61F2/86 , A61F2/90 , A61F2/91 , A61F2002/823 , A61F2230/0054 , A61F2250/0018 , A61F2250/0039 , A61L24/043 , A61M25/1011 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , Y10S623/903
摘要： This invention is directed to methods for treating aneurysms wherein the aneurysmal sac is filled with a non-particulate agent or plurality of such agents and/or with a fluid composition which solidifies in situ. Filling of the aneurysmal sac employs sufficient amount of the non-particulate agent or plurality of such agents and/or the fluid composition to inhibit blood flow into the aneurysm sac. In addition, the methods of this invention also provide for non-endogenous isolation of the parent artery proximal and distal to the aneurysmal sac from systemic blood flow of the treated mammal. The combination of these features provides for treatment of the aneurysmal sac while, at the same time, inhibiting aneurysm formation and/or regrowth in the diseased portions of the arterial wall proximal and distal to the treated aneurysm.
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公开(公告)号：EP1333760A4
公开(公告)日：2005-01-26
申请号：EP01916100
申请日：2001-03-08
摘要： Disclosed are methods for vascular reconstruction of diseased, non-aneurysmal arteries (102).
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公开(公告)号：EP1180051A4
公开(公告)日：2004-06-30
申请号：EP00936080
申请日：2000-05-19
发明人： WHALEN THOMAS J II , TRAN CHINH NGOC , HAYMAN DOUGLAS RAY , ROTH NOAH MICHAEL , GREFF RICHARD J , MORET JAQUES
IPC分类号： A61B17/00 , A61B17/12 , A61K49/04 , A61L24/00 , A61L24/04 , A61L24/06 , A61L24/08 , A61L31/00 , A61M5/44 , A61M25/00 , A61M31/00 , A61M36/04 , C08J3/09
CPC分类号： C08J3/091 , A61K49/0419 , A61L24/001 , A61L24/046 , A61L24/06 , A61L24/08 , A61L2430/36 , A61M2025/1052 , C08L29/04
摘要： Disclosed are novel techniques for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery of an embolic composition.
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5.发明公开CATHETER SYSTEM AND METHOD FOR INJECTION OF A LIQUID EMBOLIC COMPOSITION AND A SOLIDIFICATION AGENT 有权导管系统和方法注射液栓塞组成整理中的生产资料
公开(公告)号：EP1030703A4
公开(公告)日：2000-11-22
申请号：EP98961717
申请日：1998-09-23
发明人： CRAGG ANDREW H , GREFF RICHARD J , PECOR ROBERT , PERL JOHN , WALKER BLAIR , WALLACE GEORGE
CPC分类号： A61B17/12022 , A61B17/00491 , A61B17/12113 , A61B17/12186 , A61B90/39 , A61B2017/00495 , A61B2017/1205 , A61M25/00 , A61M25/0097 , A61M2025/0034 , A61M2025/0037 , A61M2025/0039
摘要： A catheter according to the present invention includes a multiple lumen catheter (10) for delivery of a liquid embolic composition through a first lumen, and delivery of a solidification agent through a second lumen. The catheter allows adjustment of the relative longitudinal position of the two lumens to control the solidification of the embolic composition within a blood vessel. The multiple lumen catheter system (10) is used by inserting the catheter endo-vascularly into an aneurysm site, and injecting a liquid embolic composition through the first lumen while injecting a solidification agent through the second lumen to wash the area of the aneurysm of blood which has become saturated with solvent, while replacing it with a fresh solidification agent. The controlled solidification of the liquid embolic composition by use of the solidification agent allows the aneurysm to be filled precisely, and rapidly even when the aneurysm is located such that gravity does not cause the liquid embolic composition to flow into the aneurysm.
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6.发明公开METHODS FOR INHIBITING THE FORMATION OF ENDOLEAKS ASSOCIATED WITH ENDOVASCULAR REPAIR OF ABDOMINAL AORTIC ANEURYSMS 有权INHIBITING ENDOLECKEN ASSOZIERT肚皮主动脉瘤腔内修复
公开(公告)号：EP1163012A4
公开(公告)日：2004-04-14
申请号：EP00918170
申请日：2000-03-20
发明人： RICCI CHARLIE , DOLMATCH BART , CRAGG ANDREW H , GREFF RICHARD J
IPC分类号： A61B17/00 , A61B17/12 , A61K47/08 , A61K47/10 , A61K47/20 , A61K47/32 , A61K47/38 , A61K47/48 , A61K49/04 , A61L31/00 , A61M25/00 , A61L24/00 , A61L24/06 , A61L24/08
CPC分类号： A61B17/12186 , A61B17/00491 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61K47/6957
摘要： Disclosed are methods for inhibiting endoleak formation associated with endovascular repair of abdominal aortic aneurysms.
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公开(公告)号：EP1066067A4
公开(公告)日：2001-03-14
申请号：EP99908494
申请日：1999-02-26
发明人： GREFF RICHARD J
IPC分类号： A61B17/12 , A61B17/00 , A61B17/42 , A61L24/00 , A61L24/06 , A61M25/00 , A61M37/00 , A61B1/00 , A61K49/04
CPC分类号： A61B17/42 , A61B17/00491 , A61B17/12022 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B2017/4216 , A61L24/001 , A61L24/02 , A61L24/06 , A61L31/18 , A61L2430/36 , A61M31/005 , C08L29/04
摘要： This invention is directed to novel methods for gynecologic embolotherapy. The methods directly access the blood vessels to be embolized transcervically rather than arterially. The methods provide precise directed delivery of embolizing compositions, and are particularly suited for treating uterine fibroids. Kits containing one or more devices for transcervical injection and an embolizing composition are also provided. In a preferred embodiment, fluid embolizing compositions are used. In a more preferred embodiment, these fluid embolic compositions comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent. In a most preferred embodiment, the contrast agent is characterized by having an average particle size of about 10 νm or less.
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8.发明公开CONTOURED SYRINGE AND NOVEL LUER HUB AND METHODS FOR EMBOLIZING BLOOD VESSELS 失效变形注射器和新型发光片及栓装血管的方法
公开(公告)号：EP0989870A4
公开(公告)日：2000-08-30
申请号：EP98930062
申请日：1998-06-12
发明人： JONES MICHAEL L , GREFF RICHARD J
IPC分类号： A61M5/31 , A61B17/12 , A61B19/00 , A61M5/00 , A61M5/315 , A61M25/00 , A61M31/00 , A61M35/00 , A61M37/00 , A61M39/00
CPC分类号： A61M37/0069 , A61B17/12022 , A61B17/12186 , A61B90/39 , A61B2017/1205 , A61M31/00 , A61M31/007 , A61M35/003
摘要： Disclosed are novel syringes (10) and catheters (34) for delivering compositions which form solid masses in vivo. These syringes (10) and catheters (34) are particularly useful for delivering embolizing compositions intravascularly.
摘要翻译： 公开了用于递送在体内形成固体物质的组合物的新型注射器（10）和导管（34）。 这些注射器（10）和导管（34）特别适用于血管内递送栓塞组合物。
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公开(公告)号：EP0936890A4
公开(公告)日：2000-01-26
申请号：EP97911674
申请日：1997-10-10
发明人： WALLACE GEORGE , GREFF RICHARD J
IPC分类号： A61F2/04 , A61F2/00 , A61L24/06 , A61L24/08 , A61L27/16 , A61L27/20 , A61L31/04 , A61F2/02 , A61L27/00 , A61L31/00
CPC分类号： A61L31/042 , A61F2/0036 , A61L24/06 , A61L24/08 , A61L27/16 , A61L27/20 , A61L31/048 , A61L2430/36 , A61L27/50 , A61F2/00 , C08L1/12 , C08L33/20 , C08L33/08 , C08L29/04 , C08L33/00
摘要： A kit of parts comprising : a first member which is an embolic composition comprising a biocompatible polymer and a biocompatible solvent; and a second member which is a needle selected from the group consisting of a puncture needle and spinal needle.
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公开(公告)号：EP0841854A4
公开(公告)日：2000-01-26
申请号：EP96925567
申请日：1996-07-29
发明人： GREFF RICHARD J , JONES MICHAEL L , EVANS SCOTT
IPC分类号： A61K47/48 , A61K49/04 , A61L24/00 , A61L24/04 , A61L24/06 , A61L24/08 , C08K3/08 , C08K3/22 , C08K3/30 , C08L23/08 , C08L29/04 , A61L25/00 , A61L27/00 , A61L31/00
CPC分类号： A61L24/08 , A61K49/0404 , A61K49/0414 , A61L24/001 , A61L24/046 , A61L24/06 , A61L2430/36 , C08L29/04
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise an ethylene vinyl alcohol copolymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.
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