公开(公告)号：EP1891115A2

公开(公告)日：2008-02-27

申请号：EP06710553.6

申请日：2006-02-20

申请人： HELLENIC PASTEUR INSTITUTE ,  MAMALAKI, Avgi

发明人： Mamalaki, Avgi ,  Belimezi, Maria ,  Papanastassiou, Danai ,  Merkouri, Efrossini ,  Baxevanis, Konstantinos

IPC分类号： C07K16/32 ,  C12N15/13 ,  C12N15/70 ,  C12N1/21 ,  A61P35/00 ,  A61K39/395 ,  A61K48/00 ,  G01N33/577 ,  G01N33/574

CPC分类号： C07K16/32 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/82

摘要： The present application describes an isolated antibody or a fragment, variant or derivative thereof / capable of specifically binding to Her2/neu comprising a heavy chain variable domain wherein said heavy chain variable domain comprises an amino acid sequence as set out in at least one of SEQ ID NOs: 1, 2 or 3 or a sequence having at least 75% identity (homology) thereto or a functional fragment thereof as well as nucleic acid sequences encoding the same and methods for their production. The application also relates to a method for the treatment of Her2/neu expressing cancer in a patient comprising administering to the patient in need of such treatment a therapeutically effective amount of any of those antibody, polypeptide or nucleic acid molecules described herein.

公开(公告)号：EP1509605A2

公开(公告)日：2005-03-02

申请号：EP03712468.2

申请日：2003-04-15

申请人： HELLENIC PASTEUR INSTITUTE ,  ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES ,  TZARTOS, Socrates ,  MAMALAKI, Avgi

发明人： TZARTOS, Socrates ,  MAMALAKI, Avgi ,  PSARIDI-LINARDAKI, Loukia ,  KOSTELIDOU, Kalliopi

IPC分类号： C12N15/12 ,  C07K14/705 ,  A61K38/17

CPC分类号： C07K14/70571 ,  A61K38/00

摘要： A procedure which involves the production of extracellular domains (or larger parts including these domains) of human muscle acetylcholine receptor (AChR) expressed in heterologous or homologous systems and obtained in sufficiently folded state appropriate for binding major fractions of anti-AChR antibodies in myasthenia gravis (MG) patients and of immunoadsorbing these antibodies when said polypeptides are used as permanently immobilized on insoluble matrixes. This procedure allows the ex vivo selective elimination of the antibodies against human muscle acetylcholine receptor (AChR), as a replacement and improvement of the non-specific plasmapheresis or Ig apheresis, for the temporary repeated treatment of the disease MG.

公开(公告)号：EP2195339A2

公开(公告)日：2010-06-16

申请号：EP08788798.0

申请日：2008-08-22

申请人： Hellenic Pasteur Institute ,  Mamalaki, Avgi

发明人： MAMALAKI, Avgi ,  MARINOU, Martha ,  KOLIARAKI, Vasiliki

IPC分类号： C07K14/575 ,  C07K16/26 ,  A61K38/22 ,  A61K39/395 ,  G01N33/68 ,  G01N33/78 ,  C12P21/02

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K16/26 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2319/21 ,  C07K2319/41 ,  G01N33/74

摘要： The present invention provides a novel method for producing biologically functional hepcidin in Pichia pastoris. The invention further provides novel tagged hepcidin, antibodies and their uses in therapy and immunoassays.

公开(公告)号：EP1509605B1

公开(公告)日：2009-09-30

申请号：EP03712468.2

申请日：2003-04-15

申请人： HELLENIC PASTEUR INSTITUTE ,  ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES ,  TZARTOS, Socrates ,  MAMALAKI, Avgi

发明人： TZARTOS, Socrates ,  MAMALAKI, Avgi ,  PSARIDI-LINARDAKI, Loukia ,  KOSTELIDOU, Kalliopi

IPC分类号： C12N15/12 ,  C07K14/705 ,  A61K38/17

CPC分类号： C07K14/70571 ,  A61K38/00

摘要： A procedure which involves the production of extracellular domains (or larger parts including these domains) of human muscle acetylcholine receptor (AChR) expressed in heterologous or homologous systems and obtained in sufficiently folded state appropriate for binding major fractions of anti-AChR antibodies in myasthenia gravis (MG) patients and of immunoadsorbing these antibodies when said polypeptides are used as permanently immobilized on insoluble matrixes. This procedure allows the ex vivo selective elimination of the antibodies against human muscle acetylcholine receptor (AChR), as a replacement and improvement of the non-specific plasmapheresis or Ig apheresis, for the temporary repeated treatment of the disease MG.