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    IP3 RECEPTOR LIGANDS
    3.
    发明公开
    IP3 RECEPTOR LIGANDS 有权
    IP3受体配体

    公开(公告)号：EP1188760A1

    公开(公告)日：2002-03-20

    申请号：EP00929862.1

    申请日：2000-05-25

    申请人： DAIICHI PHARMACEUTICAL CO., LTD. ,  Nagano, Testuo

    发明人： NAGANO, Tetsuo ,  KIKUCHI, Kazuya ,  INOUE, Takanari ,  IINO, Masamitsu ,  HIROSE, Kenzo

    IPC分类号： C07F9/144 ,  C07F9/655 ,  C07F9/6561 ,  C07D493/10 ,  A61K31/661 ,  A61K41/00 ,  A61P43/00

    CPC分类号： C07F9/6561 ,  C07F9/117 ,  C07F9/65522

    摘要： A compound represented by the general formula (I) or a salt thereof, wherein R represents a group represented by the following formula (A), (B) or (C) wherein R 1 and R 2 independently represent a C 1-6 alkyl group, R 3 represents an amino group, a mono(C 1-6 alkyl)amino group, a di(C 1-6 alkyl)amino group or a C 1-6 alkoxy group and X-represents an anion, and n represents an integer of 2 to 5. The compound or a salt is useful as a ligand of inositol-1,4,5-trisphosphate (IP 3 ) receptor.

    摘要翻译： 由通式（I）表示的化合物或其盐，其中R表示由下式（A），（B）或（C）表示的基团，其中R 1和R 2独立地表示C 1-6烷基，R 3 表示氨基，单（C 1-6烷基）氨基，二（C 1-6烷基）氨基或C 1-6烷氧基，X - 表示阴离子，n表示2〜5的整数。 该化合物或盐可用作肌醇-1,4,5-三磷酸（IP3）受体的配体。

    REAGENT FOR SINGLET OXYGEN DETERMINATION
    5.
    发明授权
    REAGENT FOR SINGLET OXYGEN DETERMINATION 有权
    试剂单线态氧的检测

    公开(公告)号：EP1069121B1

    公开(公告)日：2003-07-16

    申请号：EP99912055.3

    申请日：1999-03-31

    申请人： Nagano, Testuo

    发明人： NAGANO, Tetsuo ,  UMEZAWA, Naoki

    IPC分类号： C07D311/82 ,  C07D493/08 ,  C07D493/10 ,  C07D493/22 ,  G01N33/48 ,  G01N21/78

    CPC分类号： C07D493/08 ,  C07D311/82 ,  C07D493/10 ,  G01N31/225 ,  Y10S436/80

    摘要： Compounds represented by general formula (I) or salts thereof, wherein R?1, R2, R3, R4, R5, and R6¿ each independently represents hydrogen, halogeno, C¿1-6? alkyl, or C1-6 alkoxyl; R?7 and R8¿ each independently represents C¿1-6? alkyl or optionally substituted aryl; R?9 and R10¿ each independently represents hydrogen, C¿1-6? alkyl, or C1-6 alkoxyl; and R?11¿ represents hydrogen or C¿1-12? alkanoyl. The compounds are substantially nonfluorescent and react with singlet oxygen under physiological conditions to give a fluorescent substance. They are hence useful as a reagent for singlet oxygen determination.

    DIAMINORHODAMINE DERIVATIVES
    6.
    发明授权
    DIAMINORHODAMINE DERIVATIVES 失效
    二氨基十二胺衍生物

    公开(公告)号：EP1000941B1

    公开(公告)日：2003-08-13

    申请号：EP98929754.4

    申请日：1998-06-30

    申请人： Nagano, Testuo

    发明人： NAGANO, Tetsuo ,  KOJIMA, Hirotatsu, Adachi

    IPC分类号： C07D311/84 ,  G01N21/78 ,  G01N33/52 ,  C07D311/90

    CPC分类号： G01N31/223 ,  C07D311/82 ,  C09B11/24 ,  Y10T436/177692

    摘要： Compounds represented by general formula (1), and reagents containing the same for determining nitrogen monoxide (wherein R?1 and R2¿ are amino groups bonded to the phenyl ring at positions adjacent to each other; R?3, R4, R5 and R6¿ are each independently C¿1?-C6 alkyl; R?7, R8, R9 and R10¿ are each independently hydrogen, C¿1?-C6 alkyl, allyl or halogeno; R?11¿ is hydrogen or C¿1?-C18 alkyl; and X?-¿ is an anion). The compounds react with nitrogen monoxide efficiently to produce fluorescent compounds which emit intensive fluorescence when irradiated with a long-wavelength excitation light. The fluorescent compounds are detectable in a fluorescence region wherein little influence of autofluorescence of cells is observed, and characterized in that the intensity of fluorescence is not lowered even under acid conditions.

    摘要翻译： 通式（1）表示的化合物和含有其的用于测定一氧化氮的试剂（其中R 1和R 2是彼此相邻位置与苯环键合的氨基; R 3，R 4，R 5和R 6 各自独立地为C 1 -C 6烷基; R 7，R 8，R 9和R 10各自独立地为氢，C 1 -C 6烷基，烯丙基或卤代; R 11为氢或C 1〜 -C 18烷基;并且X 5是一个阴离子）。 这些化合物与一氧化氮高效地反应生成荧光化合物，当用长波长激发光照射时，荧光化合物发出强烈的荧光。 荧光化合物在荧光区域中可检测到，其中观察到细胞自发荧光的影响很小，并且特征在于即使在酸性条件下荧光强度也不降低。

    REAGENT FOR SINGLET OXYGEN DETERMINATION
    7.
    发明公开
    REAGENT FOR SINGLET OXYGEN DETERMINATION 有权
    REAGENZ ZUM NACHWEIS VON SINGULETT-SAUERSTOFF

    公开(公告)号：EP1069121A1

    公开(公告)日：2001-01-17

    申请号：EP99912055.3

    申请日：1999-03-31

    申请人： Nagano, Testuo

    发明人： NAGANO, Tetsuo ,  UMEZAWA, Naoki

    IPC分类号： C07D311/82 ,  C07D493/08 ,  C07D493/10 ,  C07D493/22 ,  G01N33/48 ,  G01N21/78

    CPC分类号： C07D493/08 ,  C07D311/82 ,  C07D493/10 ,  G01N31/225 ,  Y10S436/80

    摘要： Compounds represented by general formula (I) or salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 each independently represents hydrogen, halogeno, C 1-6 alkyl, or C 1-6 alkoxyl; R 7 and R 8 each independently represents C 1-6 alkyl or optionally substituted aryl; R 9 and R 10 each independently represents hydrogen, C 1-6 alkyl, or C 1-6 alkoxyl; and R 11 represents hydrogen or C 1-12 alkanoyL The compounds are substantially nonfluorescent and react with singlet oxygen under physiological conditions to give a fluorescent substance. They are hence useful as a reagent for singlet oxygen determination.

    摘要翻译： 由通式（I）表示的化合物或其盐，其中R 1，R 2，R 3，R 4，R 5和R 6各自独立地表示氢，卤素， C 1-6烷基或C 1-6烷氧基; R 7和R 8各自独立地表示C 1-6烷基或任选取代的芳基; R 9和R 10各自独立地表示氢，C 1-6烷基或C 1-6烷氧基; 并且R 11表示氢或C 1-12烷基。化合物基本上是非荧光的，并且在生理条件下与单线态氧反应，得到荧光物质。 因此它们可用作单线态氧测定的试剂。

    DIAMINORHODAMINE DERIVATIVES
    8.
    发明公开
    DIAMINORHODAMINE DERIVATIVES 失效
    DIAMINORHODAMIN衍

    公开(公告)号：EP1000941A4

    公开(公告)日：2002-07-31

    申请号：EP98929754

    申请日：1998-06-30

    申请人： NAGANO TESTUO

    发明人： NAGANO TETSUO ,  KOJIMA HIROTATSU ADACHI

    IPC分类号： A61K31/352 ,  C07D249/04 ,  C07D311/82 ,  C07D311/88 ,  C07D311/96 ,  C07D493/10 ,  G01N31/22 ,  G01N33/00 ,  C07D311/84 ,  C07D311/90 ,  G01N21/78 ,  G01N33/52

    CPC分类号： G01N31/223 ,  C07D311/82 ,  C09B11/24 ,  Y10T436/177692

    摘要： Compounds represented by general formula (1), and reagents containing the same for determining nitrogen monoxide (wherein R?1 and R2¿ are amino groups bonded to the phenyl ring at positions adjacent to each other; R?3, R4, R5 and R6¿ are each independently C¿1?-C6 alkyl; R?7, R8, R9 and R10¿ are each independently hydrogen, C¿1?-C6 alkyl, allyl or halogeno; R?11¿ is hydrogen or C¿1?-C18 alkyl; and X?-¿ is an anion). The compounds react with nitrogen monoxide efficiently to produce fluorescent compounds which emit intensive fluorescence when irradiated with a long-wavelength excitation light. The fluorescent compounds are detectable in a fluorescence region wherein little influence of autofluorescence of cells is observed, and characterized in that the intensity of fluorescence is not lowered even under acid conditions.

    摘要翻译： 通式（1）表示的化合物和含有其的用于测定一氧化氮的试剂（其中R 1和R 2是彼此相邻位置与苯环键合的氨基; R 3，R 4，R 5和R 6 各自独立地为C 1 -C 6烷基; R 7，R 8，R 9和R 10各自独立地为氢，C 1 -C 6烷基，烯丙基或卤代; R 11为氢或C 1〜 -C 18烷基;并且X 5是一个阴离子）。 这些化合物与一氧化氮高效地反应生成荧光化合物，当用长波长激发光照射时，荧光化合物发出强烈的荧光。 荧光化合物在荧光区域中可检测到，其中观察到细胞自发荧光的影响很小，并且特征在于即使在酸性条件下荧光强度也不降低。

    DIAMINORHODAMINE DERIVATIVES
    9.
    发明公开
    DIAMINORHODAMINE DERIVATIVES 失效
    二氨基十二胺衍生物

    公开(公告)号：EP1000941A1

    公开(公告)日：2000-05-17

    申请号：EP98929754.4

    申请日：1998-06-30

    申请人： Nagano, Testuo

    发明人： NAGANO, Tetsuo ,  KOJIMA, Hirotatsu, Adachi

    IPC分类号： C07D311/84 ,  G01N21/78 ,  G01N33/52

    CPC分类号： G01N31/223 ,  C07D311/82 ,  C09B11/24 ,  Y10T436/177692

    摘要： A compound represented by the following general formula:
    wherein R 1 and R 2 represent amino groups present at adjacent positions each other on the phenyl ring; R 3 , R 4 , R 5 and R 6 independently represent a C 1-6 alkyl group; R 7 , R 8 , R 9 and R 10 independently represent a hydrogen atom, a C 1-6 alkyl group, an allyl group, or a halogen atom; R 11 represents a hydrogen atom or a C 1-18 alkyl group; and X - represents an anion, and an agent for nitric oxide measurement comprising said compound.
    The compound efficiently reacts with nitric oxide to give a fluorescent compound that emits strong fluorescence by irradiation with excitation light of a long wavelength. This fluorescent compound is characterized in that said compound is detectable in a fluorescence wavelength range hardly influenced by autofluorescence of cells, and its fluorescence intensity is not attenuated under an acidic condition.

    摘要翻译： 由下列通式表示的化合物：其中R1和R2代表苯环上相邻位置上存在的氨基; R3，R4，R5和R6独立地代表C1-6烷基; R7，R8，R9和R10独立地表示氢原子，C1-6烷基，烯丙基或卤素原子; R11代表氢原子或C1-18烷基; X-代表阴离子，以及包含所述化合物的用于测量一氧化氮的试剂。 该化合物与一氧化氮有效地反应，得到通过用长波长的激发光照射而发出强荧光的荧光化合物。 该荧光化合物的特征在于，所述化合物在几乎不受细胞自发荧光影响的荧光波长范围内可检测，其荧光强度在酸性条件下不衰减。