SINGLE-STRAND FORM POLYNUCLEOTIDE AND USE THEREOF IN GENOME EDITING

    公开(公告)号:EP4502157A1

    公开(公告)日:2025-02-05

    申请号:EP23780856.3

    申请日:2023-03-30

    Inventor: MASEDA, Hideaki

    Abstract: The present invention provides: a single-strand form polynucleotide for editing that is capable of modifying a target site in double-strand genomic DNA and that includes, as a structural unit, a nucleotide analog with a high affinity for DNA; a genome editing kit that includes said polynucleotide for editing; a genome editing kit that includes said polynucleotide for editing and a polynucleotide for promoting editing or an expression vector thereof; a method for modifying a target site in double-strand genomic DNA of a cell or a non-human organism, the method comprising a step for using the genome editing kit to treat a cell or an organism; and a method for producing a cell or an organism in which a target site in double-strand genomic DNA is modified, the method comprising said step.

    ELECTRONIC/OPTICAL DEVICE AND MANUFACTURING METHOD THEREFOR

    公开(公告)号:EP4456145A1

    公开(公告)日:2024-10-30

    申请号:EP22910680.2

    申请日:2022-11-16

    Abstract: Provided are an electronic/optical device, which is reduced in contact resistance occurring between a layered material layer and a metal electrode layer, and a method of manufacturing the device. The electronic/optical device of the present invention includes a laminated structure in which an intermediate layer is arranged between a layered material layer (2) and a metal electrode layer (3). The intermediate layer is a crystal layer (4) of an intermediate layer-forming material containing: at least one of Sb and Bi; and Te. In addition, the method of manufacturing an electronic/optical device of the present invention includes: an intermediate layer-forming step of forming, on the layered material layer (2), the intermediate layer (crystal layer (4)) obtained by crystallizing an intermediate layer-forming material containing: at least one of Sb and Bi; and Te; and a metal electrode layer-forming step of forming the metal electrode layer (3) on the intermediate layer.

    HIGH-PRESSURE HYDROGEN SUPPLY SYSTEM AND METHOD THEREOF

    公开(公告)号:EP4389698A1

    公开(公告)日:2024-06-26

    申请号:EP22858316.7

    申请日:2022-08-03

    Abstract: A purpose of the present invention is to provide a pumpless high-pressure hydrogen supply system capable of supplying high-pressure hydrogen to a fuel cell vehicle, etc., when needed without using a compressor or the like, and a method for the system. The present invention relates to a high-pressure hydrogen supply system that obtains a mixed gas of hydrogen and carbon dioxide by dehydrogenation of formic acid using a complex catalyst, separates the hydrogen therefrom, and supplies the hydrogen at a pressure of 5 MPa or more. By obtaining the mixed gas at a pressure of 5 MPa or more by dehydrogenation and cooling the mixed gas by a separator while maintaining this pressure at 0.4 MPa or more, gas components other than hydrogen are phase separated as liquids or solids and removed. The separated hydrogen is raised in purity by pressure fluctuation adsorption, continuously sent to a pressure accumulator, and stored at a pressure of 70 MPa or more.

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