利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

54 条记录 (耗时 0.026 秒)

    METHOD FOR EVALUATING FIBRINOLYSIS RESISTANCE ACTIVITY IN BLOOD PLASMA
    1.
    发明公开
    METHOD FOR EVALUATING FIBRINOLYSIS RESISTANCE ACTIVITY IN BLOOD PLASMA 审中-实审

    公开(公告)号：EP4425183A1

    公开(公告)日：2024-09-04

    申请号：EP22887189.3

    申请日：2022-10-28

    申请人： National University Corporation Hamamatsu University School of Medicine

    发明人： SUZUKI Yuko ,  URANO Tetsumei

    IPC分类号： G01N33/86 ,  C12Q1/37 ,  G01N33/48

    CPC分类号： C12Q1/37 ,  G01N33/86 ,  G01N33/48

    摘要： An object of the present invention is to provide a method for easily evaluating residual fibrinolytic resistance activity by PAI-1 and α2AP in blood plasma. The present invention is a method of evaluating fibrinolytic resistance activity, the method including a pretreatment step of adding an anionic surfactant to some of a blood plasma sample derived from a test animal and incubating the blood plasma for a predetermined time, a first fibrinolytic resistance measurement step of measuring an index value of fibrinolytic resistance activity in treated blood plasma obtained by the pretreatment step, a second fibrinolytic resistance measurement step of measuring an index value of fibrinolytic resistance activity in some of the blood plasma sample derived from the test animal, and an evaluation step of evaluating the fibrinolytic resistance activity by PAI-1 and α2AP in the blood plasma of the test animal, based on the index value measured in the first fibrinolytic resistance measurement step and the index value of untreated blood plasma measured in the second fibrinolytic resistance measurement step.

    IMMUNOCHROMATOGRAPHY ASSAY KIT
    2.
    发明公开
    IMMUNOCHROMATOGRAPHY ASSAY KIT 审中-公开

    公开(公告)号：EP4242657A1

    公开(公告)日：2023-09-13

    申请号：EP21889181.0

    申请日：2021-11-02

    申请人： NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE ,  NTN Corporation

    发明人： HARIYAMA, Takahiko ,  KAWASAKI, Hideya ,  OHBA, Hiroaki

    IPC分类号： G01N33/543

    摘要： An immunochromatography assay kit (100) includes a specimen dropping portion (1) to which a specimen is dropped, a conjugate portion (2) to which a labeled antibody having a property of binding to a detection target in the specimen is immobilized, and a plurality of detection portions (3) to which a capture antibody having a property of binding to the detection target is immobilized. The specimen dropping portion (1), the conjugate portion (2), and the plurality of detection portions (3) are formed on a porous member. An outer shape of each detection portion (3) is a dot shape.

    FRAGRANCE COMPOSITION
    3.
    发明公开
    FRAGRANCE COMPOSITION 审中-公开

    公开(公告)号：EP3998327A1

    公开(公告)日：2022-05-18

    申请号：EP20839991.5

    申请日：2020-07-11

    申请人： NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE ,  National University Corporation Kobe University

    发明人： HARIYAMA, Takahiko ,  OZAKI, Mamiko

    IPC分类号： C11B9/00 ,  A61Q13/00 ,  A23L27/00 ,  A23L27/20 ,  A61K8/31 ,  A61K8/35

    摘要： The present invention provides an odorant composition having good palatability allowing peoples to feel comfortable using a small number of chemical compounds. An odorant composition according to an embodiment of the present invention consists of: when the total mass of ingredients contained in the odorant composition is 100.0% by mass, 40.0% by mass or more and 97.5% by mass or less of an ingredient (A) composed of aldehydes; 1.0% by mass or more and 20.0% by mass or less of an ingredient (B) composed of a ketone(s); and the balance being an ingredient (C) composed of a chemical compound(s) other than the ingredient (A) and the ingredient (B). The aldehydes of the ingredient (A) are: an essential ingredient (A1) composed of nonanal; and an optional ingredient (A2) selected from the group consisting of decanal, heptanal, octanal, benzaldehyde, undecanal, hexanal, and combinations thereof. The ketone(s) of the ingredient (B) is selected from the group consisting of 6-methyl-5-hepten-2-one, cyclohexanone, 1-phenylethanone, 2-decanone, 2-undecanone, and combinations thereof. The chemical compound(s) of the ingredient (C) is selected from the group consisting of limonene, 1,8-cineole, menthol, 1-octanol, 3-hexyn-1-ol, 2-nonen-1-ol, dodecane, hexanoic acid, octanoic acid, nonanoic acid, 2(5H)-furanone, p-cymene, sotolon, and combinations thereof.

    CELL OBSERVATION SYSTEM AND CELL OBSERVATION METHOD
    5.
    发明公开
    CELL OBSERVATION SYSTEM AND CELL OBSERVATION METHOD 审中-公开

    公开(公告)号：EP3933377A1

    公开(公告)日：2022-01-05

    申请号：EP20762318.2

    申请日：2020-02-14

    申请人： National University Corporation Hamamatsu University School of Medicine ,  Hamamatsu Photonics K.K.

    发明人： KIKUCHI Hirotoshi ,  YAMADA Hidenao ,  HIROTSU Amane ,  YAMASHITA Daisuke ,  OKAZAKI Shigetoshi

    IPC分类号： G01N15/14 ,  C12M1/34 ,  C12Q1/04

    摘要： A cell observation system 1 observes a cell 30 moving in a flow path 10 with a fluid 20, and includes a first imaging apparatus 40, a second imaging apparatus 50, and a control device 60. The first imaging apparatus 40 includes a first optical system 41 and a first imaging element 42, and captures an image of the cell at a first position in a moving direction of the cell in the flow path. The second imaging apparatus 50 includes a second optical system 51, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element 52, and captures an image of the cell at a second position downstream of the first position. The control device 60 obtains a passing position of the cell in a cross section of the flow path based on the image obtained by imaging by the first imaging element 42, generates the focus adjustment signal based on the obtained passing position, and provides the signal to the second optical system 51. Thus, a cell observation system capable of relaxing restriction of a flow speed of a cell due to a focusing speed is realized.

    OPTICAL MEASUREMENT DEVICE
    8.
    发明公开
    OPTICAL MEASUREMENT DEVICE 审中-公开
    光学测量装置

    公开(公告)号：EP2679981A1

    公开(公告)日：2014-01-01

    申请号：EP12750039.5

    申请日：2012-02-23

    申请人： National University Corporation Shizuoka University ,  National University Corporation Hamamatsu University School of Medicine

    发明人： NIWAYAMA, Masatsugu ,  KANAYAMA, Naohiro ,  SUZUKI, Kazunao

    IPC分类号： G01N21/17 ,  A61B10/00

    CPC分类号： A61B5/0059 ,  A61B5/14551 ,  A61B5/4872 ,  A61B2562/0242 ,  G01N21/4738 ,  G01N21/49 ,  G01N2021/4742

    摘要： An accurate measurement can be made of the light absorbance of deep layer tissue such as in a human body or a fruit.
    The thickness of fat is computed (104). A first specific distance and a second specific distance corresponding to the computed fat thickness are computed based a predetermined relationship between the fat thickness, the first specific distance, and measurement sensitivity of a surface layer and measurement sensitivity of a deep layer when light is received at a position the first specific distance away from a light emitting means (106). A third specific distance and a fourth specific distance are computed corresponding to the computed fat thickness based on a predetermined relationship between the fat thickness, the third specific distance and a measurement sensitivity of an intervening layer and a measurement sensitivity of the deep layer when light is received at a position the third specific distance away from the light emitting means (108).

    摘要翻译： 可以精确测量人体或水果等深层组织的吸光度。 计算脂肪的厚度（104）。 基于脂肪厚度，第一特定距离和表面层的测量灵敏度与深层的测量灵敏度之间的预定关系，计算与计算出的脂肪厚度相对应的第一特定距离和第二特定距离 第一特定距离远离发光装置（106）的位置。 基于脂肪厚度，第三特定距离和中间层的测量灵敏度之间的预定关系，以及当光为中间层时的深层的测量灵敏度，计算与计算出的脂肪厚度相对应的第三特定距离和第四特定距离 在距离发光装置（108）第三特定距离的位置处被接收。

    METHOD AND MARKER FOR DETERMINATION OF DEGREE OF RISK OF ONSET OF HIGH-FUNCTIONING AUTISM
    10.
    发明公开
    METHOD AND MARKER FOR DETERMINATION OF DEGREE OF RISK OF ONSET OF HIGH-FUNCTIONING AUTISM 有权
    VERFAHREN UND MARKER ZUR BESTIMMUNG DES RISIKOGRADESFÜRDEN AUSBRUCH VON HIGH-FUNCTIONING-AUTISMUS

    公开(公告)号：EP2490028A1

    公开(公告)日：2012-08-22

    申请号：EP10823205.9

    申请日：2010-10-14

    申请人： National University Corporation Hamamatsu University School of Medicine

    发明人： MORI, Norio ,  NAKAMURA, Kazuhiko ,  SUZUKI, Katsuaki ,  TSUCHIYA, Kenji ,  IWATA, Keiko ,  MATSUZAKI, Hideo

    IPC分类号： G01N33/92 ,  C12Q1/26 ,  C12Q1/44 ,  C12Q1/48 ,  G01N33/15 ,  G01N33/50

    CPC分类号： G01N33/92 ,  C12Q1/60 ,  G01N2800/28

    摘要： It is an object of the present invention to provide an objective and simple method for determining the degree of risk of onset of autism, using a biological marker, and to enable to provide an appropriate treatment to the autistic patient at an early stage by finding an autistic patient at an early stage using the aforementioned method.
    The present invention relates to a method for determining the degree of risk of onset of autism, comprising the step of measuring the triglyceride concentration or the cholesterol concentration in a very low-density lipoprotein fraction of plasma or serum isolated from a subject, or the triglyceride concentration or the cholesterol concentration of plasma or serum. In addition, the present invention provides a kit for determining the degree of risk of onset of autism and a method for screening for a candidate substance for agents for treating autism using a non-human mammal, in which the above described method is utilized.

    摘要翻译： 本发明的目的是提供一种客观和简单的方法，用于使用生物标志物来确定自闭症发病风险的程度，并且能够通过发现自闭症患者在早期阶段向自闭症患者提供适当的治疗 自闭症患者早期采用上述方法。 本发明涉及一种用于确定自闭症发作风险程度的方法，包括测量从受试者分离的血浆或血清的非常低密度脂蛋白部分中的甘油三酯浓度或胆固醇浓度的步骤，或甘油三酸酯 浓度或血浆或血清的胆固醇浓度。 此外，本发明提供了一种用于确定自闭症发作风险程度的试剂盒，以及使用非人哺乳动物治疗自闭症药物的候选物质的筛选方法，其中使用了上述方法。