公开(公告)号：EP1419792A1

公开(公告)日：2004-05-19

申请号：EP02755730.5

申请日：2002-07-31

申请人： Japan Science and Technology Agency ,  National Institute for Materials Science ,  NITTA GELATIN INC.

发明人： TANAKA, Junzo ,  TAGUCHI, Tetsushi ,  MIYAZAKI, Tadasuke ,  SAKURA, Yoshiyuki ,  OHTSUKA, Tatsuro ,  MANDAI, Yoshinobu

IPC分类号： A61L27/20 ,  A61L27/44 ,  A61L27/50 ,  C08G65/322 ,  C12M3/00 ,  C08B37/00 ,  A61P19/02

CPC分类号： A61L27/3852 ,  A61L27/20 ,  A61L27/26 ,  A61L27/44 ,  A61L27/48 ,  A61L27/50 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08G65/322 ,  C08G65/329 ,  C08G65/33337 ,  C08H1/06 ,  C08L2203/02 ,  C08L5/00

摘要： Disclosed is a glycosaminoglycan-polycation complex as a matrix material for use in tissue regeneration, such as cartilage repair, and a preparation method thereof. The complex is synthesized by crosslinking glycosaminoglycan and polycation with a polyfunctional crosslinking agent under physiological conditions. In this method, the crosslinking agent consists of polyethyleneglycol having two or more electrophilic leaving groups (e.g. succinimidyl group or its derivatives) at the carboxyl terminal thereof, and the concentration of the crosslinking agent is in the range of 0.3 to 3 mM. According the present invention, the crosslinking reaction can be performed under physiological conditions to avoid conventional problems of adverse affect on cells (cell death) and the formation of a polyion complex (inhomogeneous precipitate) due to a crosslinking reaction in alcohol or water. Thus, the crosslinking reaction can be conducted in the presence of cells mixed to the glycosaminoglycan and polycation in advance.

摘要翻译： 公开的是葡糖胺聚糖 - 聚阳离子复合物作为基质材料用于组织再生，：如软骨修复的使用，以及它们的制备方法。 该复合物通过交联葡糖胺聚糖和聚阳离子在生理条件下多官能交联剂合成。 在该方法中，聚乙二醇的交联剂besteht具有在其羧基末端的两个或更多电的离去基团（E.C.琥珀酰亚胺基或它的衍生物），和交联剂的浓度是在0.3至3毫米的范围内。 。根据本发明，交联反应可以在生理条件下进行，以避免不利的传统问题对细胞（细胞死亡）和聚离子复合物（非均匀沉淀物）的形成影响归因于醇或水的交联反应。 因此，交联反应可在预先混合到糖胺聚糖和聚阳离子的细胞的存在下进行。

公开(公告)号：EP0532805B1

公开(公告)日：1997-10-08

申请号：EP91308574.2

申请日：1991-09-20

申请人： NITTA GELATIN INC.

发明人： Matsumoto, Mutsuo ,  Murotani, Yasuyoshi ,  Takemiya, Hidenori

IPC分类号： A61F13/58

CPC分类号： A61F13/58

公开(公告)号：EP0389629A4

公开(公告)日：1992-03-11

申请号：EP89907293

申请日：1989-06-22

申请人： NITTA GELATIN INC.

发明人： OONISHI, HIRONOBU ,  SUGIHARA, FUMIHITO ,  ISHII, TAKASHI ROOM 302 APPLE-TENNOJI ,  SUZUKI, KANEO ,  HATA, SEIKO ,  TAKANO, TOSHIKAZU

IPC分类号： A61F2/00 ,  A61K6/033 ,  A61L24/00 ,  A61L27/12 ,  A61L27/46 ,  A61L25/00 ,  A61K6/06

CPC分类号： A61L24/0084 ,  A61F2310/00293 ,  A61K6/0061 ,  A61K6/0085 ,  A61K6/0094 ,  A61K6/0643 ,  A61L27/12 ,  A61L27/46 ,  C08L89/06 ,  A61K6/087 ,  C08L77/02 ,  A61K6/083 ,  C08L29/04 ,  C08L39/06 ,  A61K6/097 ,  C08L5/02 ,  C08L33/08 ,  A61K6/0023

摘要： A medical and dental curable material is disclosed, which contains at least one of α-tricalcium phosphate and tetracalcium phosphate as a necessary ingredient. Conventional medical and dental curing materials containing α-tricalcium phosphate and/or tetracalcium phosphate as a necessary ingredient are unsatisfactory as to kneading workability and curing time since an aqueous solution of a single kind of organic acid is used as a curing agent. The medical and dental material of the present invention, which is satisfactory as to both kneading workability and curing time, uses as a curing-adjusting agent (1) tannin, (2) tannin and collagen, (3) collagen and organic acid, (4) tannin, collagen and organic acid, (5) tannin and organic acid or (6) at least two organic acids.

公开(公告)号：EP0454471A2

公开(公告)日：1991-10-30

申请号：EP91303770.1

申请日：1991-04-25

申请人： NITTA GELATIN INC.

发明人： Ueno, Seiki ,  Nakamura, Masaaki

IPC分类号： C09J11/00 ,  C09J201/00

CPC分类号： C09J163/00 ,  C08K3/26 ,  C08K3/32 ,  C08L2666/02 ,  C08L2666/54 ,  C09J201/00 ,  Y10T428/25 ,  Y10T428/258 ,  Y10T428/31522 ,  Y10T428/31605

摘要： An adhesive composition containing biological calcium compound as an adhesion improver. The biological calcium compound can be selected from, for example, hydroxyapatite, seashells and egg shells. The adhesive composition can give good adhesion to metals without surface pretreatment.

摘要翻译： 含有生物钙化合物作为粘合改进剂的粘合剂组合物。 生物钙化合物可以选自例如羟基磷灰石，贝壳和蛋壳。 粘合剂组合物可以在没有表面预处理的情况下赋予金属良好的附着力。

公开(公告)号：EP0364606A4

公开(公告)日：1990-10-10

申请号：EP89904606

申请日：1989-04-13

申请人： NITTA GELATIN INC.

发明人： ENAMI, JUNPEI ,  KONDO, NAOHITO ,  TAKANO, TOSHIKAZU ,  SUZUKI, KANEO

IPC分类号： C12M3/00 ,  C12N5/00

CPC分类号： C12N5/0068 ,  C12M25/14 ,  C12M25/16 ,  C12N2533/54

公开(公告)号：EP0254519A2

公开(公告)日：1988-01-27

申请号：EP87306408.3

申请日：1987-07-20

申请人： NITTA GELATIN INC.

发明人： Nonaka, Yoshihiro

IPC分类号： C02F1/04

CPC分类号： C02F1/045

摘要： A method for preparation of ultrapurified water (e.g. for washing semiconductor devices) comprises evaporating water and passing its vapor through a filter to remove fine particles and/or dissolved nonvolatile impurities which were present in the water. The initial crude water is preferably subjected to various conventional purification procedures in a preliminary treatment (1), the resulting purified water being fed from a storage tank (19) to an evaporator (22) from which the vapor passes through filter (26) to ultrapurified water storage tank (27) - from which water is preferably refluxed back to tank (19) to prevent deterioration.

摘要翻译： 制备超纯水（例如，用于洗涤半导体装置）的方法包括蒸发水并将其蒸汽通过过滤器以除去存在于水中的细小颗粒和/或溶解的不挥发性杂质。 初始粗水优选在预处理（1）中经受各种常规纯化程序，所得纯化水从储罐（19）进料到蒸发器（22），蒸发器从蒸发器（22）通过过滤器（26）至 超级储水箱（27） - 优选地将水回流回罐（19）以防止劣化。

公开(公告)号：EP1437149B1

公开(公告)日：2013-08-14

申请号：EP02800014.9

申请日：2002-09-25

申请人： NITTA GELATIN INC. ,  Tabata, Yasuhiko

发明人： TABATA, Yasuhiko ,  HIRAOKA, Yosuke ,  MANDAI, Yoshinobu

IPC分类号： A61L27/56 ,  A61L27/48

CPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/48 ,  Y10T442/2525 ,  C08L89/06

公开(公告)号：EP1419792B1

公开(公告)日：2008-07-02

申请号：EP02755730.5

申请日：2002-07-31

申请人： Japan Science and Technology Agency ,  National Institute for Materials Science ,  NITTA GELATIN INC.

发明人： TANAKA, Junzo ,  TAGUCHI, Tetsushi ,  MIYAZAKI, Tadasuke ,  SAKURA, Yoshiyuki ,  OHTSUKA, Tatsuro ,  MANDAI, Yoshinobu

IPC分类号： A61L27/20 ,  A61L27/44 ,  A61L27/50 ,  C08G65/322 ,  C12M3/00 ,  C08B37/00 ,  A61P19/02 ,  A61L27/24

CPC分类号： A61L27/3852 ,  A61L27/20 ,  A61L27/26 ,  A61L27/44 ,  A61L27/48 ,  A61L27/50 ,  C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08G65/322 ,  C08G65/329 ,  C08G65/33337 ,  C08H1/06 ,  C08L2203/02 ,  C08L5/00

摘要： In a conventional process for producing a glycosaminoglycan-polycation complex to be used in producing tissue regeneration matrixes for cartilage, etc., a crosslinking reaction is carried out in an alcohol or water. Therefore, it is feared that an injectable crosslinked biological substance might exert an undesirable effect (cell death) on cells and tissues. Moreover, a polyion complex (a non-homogeneous precipitate) is formed in this case. A glycosaminoglycan-polycation complex is formed by crosslinking glycosaminoglycan and polycation under physiological conditions with the use of 0.3 to 3 mM of a crosslinking agent which has two or more electrophilic leaving groups (for example, succinimidyl group or its derivative) at the carboxyl end of polyethylene glycol. Since the synthesis can be carried out under physiological conditions, the crosslinking can be achieved by preliminarily mixing the cells.

公开(公告)号：EP1437149A1

公开(公告)日：2004-07-14

申请号：EP02800014.9

申请日：2002-09-25

申请人： NITTA GELATIN INC. ,  Tabata, Yasuhiko

发明人： TABATA, Yasuhiko ,  HIRAOKA, Yosuke, c/o Osaka Plant ,  MANDAI, Yoshinobu, c/o Osaka Plant

IPC分类号： A61L27/44 ,  A61L27/24

CPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/48 ,  Y10T442/2525 ,  C08L89/06

摘要： The object of the present invention is to provide: a hybrid material for regeneration of living body tissue, which can retain sufficient mechanical strength for a term needed to regenerate the tissue, and which simultaneously has moderate biodegradation absorbability which enables degradation and disappearance rapidly after the regeneration of the tissue. As means for solving the problems, the hybrid material for regeneration of living body tissue, according to the present invention, comprises a naturally-occurring polymer and a biodegradation-absorbable synthetic polymer, wherein the biodegradation-absorbable synthetic polymer exists in a fibrous form in a sponge including the naturally-occurring polymer, and wherein the naturally-occurring polymer is crosslinked.

公开(公告)号：EP1281321A1

公开(公告)日：2003-02-05

申请号：EP01926142.9

申请日：2001-05-08

申请人： Kabushiki Kaisha Yakult Honsha ,  NITTA GELATIN INC.

发明人： OGASAWARA, N., c/o Kabushiki Kaisha Yakult Honsha ,  AKAHOSHI, R., c/o Kabushiki Kaisha Yakult Honsha ,  HASHIMOTO, S., c/o Kabushiki Kaisha Yakult Honsha ,  YAMASHITA, Eiichi, c/o Nitta Gelatin Inc. ,  YAMAMOTO, Keiichi, c/o Nitta Gelatin Inc.

IPC分类号： A23C9/13 ,  A23J3/04 ,  A23L1/305 ,  A23L2/66 ,  A23L2/62

CPC分类号： A23L2/66 ,  A23C9/1322 ,  A23C9/137 ,  A23C9/1526 ,  A23C9/1542

摘要： Stable acidic milk drinks characterized by composed of an acidic milk drink base together with collagen peptides obtained by hydrolyzing collagen and stabilizers. Thus, it becomes possible to add a collagen substance to the existing drinks containing various stabilizers without worsening the stability of the drinks achieved by the stabilizer.

摘要翻译： 稳定的酸性乳饮料，其特征在于由酸性乳饮料基料和通过水解胶原蛋白和稳定剂获得的胶原肽组成。 因此，可以向含有各种稳定剂的现有饮料中添加胶原物质，而不会使由稳定剂实现的饮料的稳定性恶化。