公开(公告)号：EP4397676A3

公开(公告)日：2024-10-09

申请号：EP24164808.8

申请日：2016-03-24

申请人： Immatics Biotechnologies GmbH

发明人： MAHR, Andrea ,  STEVERMANN, Lea ,  WEINSCHENK, Toni ,  SCHOOR, Oliver ,  FRITSCHE, Jens ,  SINGH, Harpreet

IPC分类号： A61K39/00 ,  C07K14/47

CPC分类号： A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/1774 ,  C12N9/6491 ,  C12Y304/24 ,  A61K39/0011 ,  A61K2039/5420130101 ,  A61K2039/5720130101 ,  A61K2039/57220130101 ,  A61K2039/58520130101 ,  A61K39/001102 ,  A61K39/001159 ,  A61K39/001154 ,  A61K39/001148 ,  A61K39/001184 ,  A61K39/001162 ,  A61K39/001152 ,  A61K39/001103 ,  A61K45/06 ,  A61K31/4745 ,  A61K31/675 ,  A61K31/404 ,  A61K31/519 ,  C12N5/0693 ,  C12N5/0636 ,  C12N5/0093 ,  C12N2510/0020130101 ,  C07K14/7051 ,  C07K14/70539 ,  C07K2319/0020130101 ,  C07K2319/5520130101 ,  C07K2319/6020130101 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  C07K14/4748 ,  A61K39/4611 ,  A61K39/4644 ,  C12N5/0638 ,  A01N37/46 ,  A61K39/00 ,  A61P35/02 ,  A61P39/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K2319/4020130101 ,  C12N5/0646

摘要： The present invention relates to a peptide, nucleic acid and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to a tumor-associated T-cell peptide epitope, alone or in combination with other tumor-associated peptides that can for example serve as an active pharmaceutical ingredient of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. The peptide bound to molecules of the major histocompatibility complex (MHC), or the peptide as such, can also be the target of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：EP4397676A2

公开(公告)日：2024-07-10

申请号：EP24164808.8

申请日：2016-03-24

申请人： Immatics Biotechnologies GmbH

发明人： MAHR, Andrea ,  STEVERMANN, Lea ,  WEINSCHENK, Toni ,  SCHOOR, Oliver ,  FRITSCHE, Jens ,  SINGH, Harpreet

IPC分类号： C07K14/47

CPC分类号： A61K38/00 ,  C07K14/70539 ,  A61K39/0011 ,  C07K14/7051 ,  C07K14/4748 ,  C07K2319/0020130101 ,  C07K14/47 ,  C07K2319/4020130101 ,  C07K14/4702 ,  C12N9/6491 ,  C12Y304/24 ,  A61P35/00 ,  A61P35/02 ,  A61P39/00 ,  A61K38/08 ,  A01N37/46 ,  A61K31/404 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/675 ,  A61K38/06 ,  A61K38/1774 ,  A61K39/001102 ,  A61K39/001103 ,  A61K39/001148 ,  A61K39/001152 ,  A61K39/001154 ,  A61K39/001159 ,  A61K39/001162 ,  A61K39/001184 ,  A61K45/06 ,  A61K2039/5420130101 ,  A61K2039/5720130101 ,  A61K2039/57220130101 ,  A61K2039/58520130101 ,  A61P37/04 ,  A61P43/00 ,  C07K2319/5520130101 ,  C07K2319/6020130101 ,  C12N5/0093 ,  C12N5/0636 ,  C12N5/0693 ,  C12N2510/0020130101 ,  A61K39/4611 ,  C12N5/0646 ,  A61K39/4644 ,  C12N5/0638 ,  A61K39/00

摘要： The present invention relates to a peptide, nucleic acid and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to a tumor-associated T-cell peptide epitope, alone or in combination with other tumor-associated peptides that can for example serve as an active pharmaceutical ingredient of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. The peptide bound to molecules of the major histocompatibility complex (MHC), or the peptide as such, can also be the target of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：EP3187578A4

公开(公告)日：2018-05-02

申请号：EP15835573

申请日：2015-08-28

申请人： HITACHI CHEMICAL CO LTD

发明人： YAGI SATOMI ,  TAKAI KENJI ,  KIKUHARA YOSHIHITO ,  TSAI ANTHONY H

IPC分类号： C12M1/00 ,  C12M1/26 ,  C12N5/00 ,  G01N33/50

CPC分类号： B01L3/502761 ,  B01J2219/00743 ,  B82Y30/00 ,  C12M33/14 ,  C12M47/02 ,  C12M47/04 ,  C12N1/02 ,  C12N5/0081 ,  C12N5/0087 ,  C12N5/0093 ,  G01N1/28 ,  G01N1/4044 ,  G01N1/4077 ,  G01N15/14 ,  G01N21/645 ,  G01N33/48728 ,  G01N33/491 ,  G01N2001/4088

摘要： Provided is a cell trapping method for selectively trapping a specific cell included in a cell-containing solution at a filter surface by filtering a liquid using a cell trapping device, the cell trapping device includes a housing which has an introduction region for introducing a liquid selected from the cell-containing solution containing two or more types of cells and a treating solution for treating the cells in the cell-containing solution into an interior, and a discharge flow path for discharging the liquid to the exterior; and a filter which is provided on a flow path between the introduction region and the discharge flow path and in which a plurality of through holes for the liquid to flow through is formed in the thickness direction, and the method includes a step of draining a liquid for n (n is a natural number) times, in which from the first step of draining the liquid to the n-th step of draining the liquid, a liquid surface of the liquid in the introduction region on the filter is maintained at a predetermined liquid surface height, and when the n-th step of draining the liquid is completed, the discharging of the liquid from the cell trapping device is stopped in a state where the liquid surface is at a predetermined height in the filter.

公开(公告)号：EP2903640A1

公开(公告)日：2015-08-12

申请号：EP12766999.2

申请日：2012-10-04

申请人： Lindhofer, Horst, Dr.

发明人： LINDHOFER, Horst ,  STROEHLEIN, Michael ,  HEISS, Markus

IPC分类号： A61K39/395 ,  A61M1/02

CPC分类号： C12N5/0093 ,  A61K35/18 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/626 ,  C12N5/0641

摘要： The invention relates to a method performed ex vivo for removal of tumor cells from intraoperatively collected blood salvage, to antibodies and scaffold proteins which mimic antibodies for use in said ex vivo method, to the use of said ex vivo method for removal of tumor cells from intraoperatively collected blood salvage followed by reintroducing the so obtained purified blood salvage or of concentrates of erythrocytes purified by said method to a patient from whom said intraoperatively collected blood was obtained, as well as to blood salvage or a concentrate of erythrocytes, both obtainable by said method for reinfusion to said patient.

摘要翻译： 本发明涉及一种从体外采集的用于从术中收集的血液挽救中去除肿瘤细胞的方法，以及模拟用于所述离体方法的抗体的抗体和支架蛋白，使用所述离体方法从肿瘤细胞中去除肿瘤细胞 术中收集的血液残余物，然后将所获得的纯化血液补救液或通过所述方法纯化的红细胞浓缩物重新引入获得所述手术中收集的血液的患者，以及血液回收或红细胞浓缩物，两者均可由所述 对所述患者进行再灌注的方法。

公开(公告)号：EP1945754B1

公开(公告)日：2014-07-23

申请号：EP06836728.3

申请日：2006-10-31

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  OncoMed Pharmaceuticals, Inc.

发明人： CLARKE, Michael F. ,  HOEY, Tim ,  WANG, Xinhao ,  DYLLA, Scott ,  GURNEY, Austin ,  DALERBA, Piero D. ,  CHEN, Grace ,  PRINCE, Mark

IPC分类号： C12N5/02 ,  G06K9/00

CPC分类号： C12N5/0695 ,  C12N5/0093 ,  Y10S435/968 ,  Y10S435/971

公开(公告)号：EP2281879A1

公开(公告)日：2011-02-09

申请号：EP10175331.7

申请日：2000-11-30

申请人： Cyntellect, Inc.

发明人： Palsson, Bernhard ,  Koller, Manfred ,  Eisfeld, Timothy ,  O'Neal, Robert

IPC分类号： C12N13/00 ,  C12M1/34 ,  G01N33/50

CPC分类号： C12N13/00 ,  C12M35/02 ,  C12M41/46 ,  C12N5/0087 ,  C12N5/0093 ,  C12N15/1034 ,  G01N15/1434 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456 ,  G01N33/5005 ,  G01N33/5091 ,  G01N33/56966 ,  G01N2021/1725 ,  Y10S128/922

摘要： This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting non-targeted cells within the mixture.

摘要翻译： 本发明提供了选择性地识别，细胞群内的能量束，特定细胞靶向并用，用于诱导靶细胞的响应为目的的方法和装置。 使用本发明，在群体中可检测到的每个细胞可以识别并受到影响，而基本上不影响该混合物内的非靶细胞。

公开(公告)号：EP1442112A4

公开(公告)日：2009-02-25

申请号：EP02799574

申请日：2002-09-09

申请人： CYNTELLECT INC

发明人： KOLLER MANFRED R ,  HANANIA ELIE G ,  EISFELD TIMOTHY M ,  PALSSON BERNHARD O

IPC分类号： C12N15/09 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  C12N5/00 ,  C12N5/06 ,  C12N13/00 ,  C12N15/10 ,  C12N15/87 ,  G01N33/50 ,  G01N33/569 ,  C12N1/18 ,  G01N33/48

CPC分类号： C12N13/00 ,  C12M35/02 ,  C12M47/06 ,  C12N5/0087 ,  C12N5/0093 ,  C12N15/1034 ,  C12N15/87 ,  G01N33/5005 ,  G01N33/5091 ,  G01N33/56966

摘要： Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse (See Figure 9) of radiation.

摘要翻译： （a）照射包含在框架中的细胞群体的瞬时透化靶细胞的Optoinjection方法; （b）检测从所述框架引导的光的至少一个属性; （c）通过光的属性来定位目标细胞; 和（d）用辐射的脉冲（见图9）照射靶细胞。

公开(公告)号：EP1553832B1

公开(公告)日：2007-07-11

申请号：EP03759533.7

申请日：2003-09-26

申请人： BioE, Inc

发明人： COLLINS, Daniel, P. ,  HAPKE, Joel, H. ,  BUCHERT, Carol, A.

IPC分类号： C12N5/06 ,  C12N5/08 ,  C12N5/00

CPC分类号： C12N5/0087 ,  A61K31/721 ,  A61K31/727 ,  A61K39/395 ,  C07K16/28 ,  C12N5/0093 ,  A61K2300/00

摘要： The invention provides compositions and methods for cell separation. These reagents and techniques specially agglutinate cells via surface recognition and can be used to recover even rare cell types in high yield.

公开(公告)号：EP1553832A4

公开(公告)日：2006-02-01

申请号：EP03759533

申请日：2003-09-26

申请人： BIOE INC

发明人： COLLINS DANIEL P ,  HAPKE JOEL H ,  BUCHERT CAROL A

IPC分类号： C12N5/02 ,  A61K31/721 ,  A61K31/727 ,  A61K39/395 ,  C07K16/28 ,  C12N5/00 ,  C12N5/07 ,  C12N5/071 ,  A01N63/00 ,  C12N5/06 ,  C12N5/08 ,  G01N33/53

CPC分类号： C12N5/0087 ,  A61K31/721 ,  A61K31/727 ,  A61K39/395 ,  C07K16/28 ,  C12N5/0093 ,  A61K2300/00

摘要： The invention provides compositions and methods for cell separation. These reagents and techniques specially agglutinate cells via surface recognition and can be used to recover even rare cell types in high yield.

公开(公告)号：EP1297121B1

公开(公告)日：2005-05-04

申请号：EP01957529.9

申请日：2001-06-26

申请人： Wellstat Biologics Corporation ,  UNIVERSITY OF OTTAWA

发明人： ATKINS, Harold, L. ,  BELL, John, C. ,  HEILMAN, Conrad, J., Jr. ,  LICHTY, Brian, D. ,  LORENCE, Robert, M. ,  ROBERTS, Michael, S. ,  STOJDL, David, F.

IPC分类号： C12N15/06 ,  C12N5/08 ,  A01N1/02 ,  A61L2/00 ,  A61K35/12 ,  A61K39/42

CPC分类号： C12N5/0093 ,  A61K35/14 ,  A61K35/28 ,  A61K35/765 ,  A61K35/766 ,  A61K35/768 ,  C12N2501/24 ,  A61K2300/00

摘要： The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating graft-versus hot diseases, and autoimmune cells. The subject invention also relates to the purging of undesirable cells from bone marrow or peripheral blood cells harvests in the treatment of mammals including cancer patients, transplant recipients and patients with autoimmune disease.