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公开(公告)号：EP4355311A1
公开(公告)日：2024-04-24
申请号：EP22825761.4
申请日：2022-06-15
发明人： FRUCHTMAN, Steven , PARRIS, Matthew
IPC分类号： A61K31/10 , C07C317/10 , A61P35/00
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2.发明授权IMPROVED STABLE AQUEOUS FORMULATION OF (E)-4-CARBOXYSTYRYL-4-CHLOROBENZYL SULFONE 有权（E-）4-羧基苯乙烯基4-氯苄基砜的改进的稳定的水性制剂
公开(公告)号：EP2552199B1
公开(公告)日：2015-06-03
申请号：EP11760239.1
申请日：2011-03-24
发明人： MANIAR, Manoj
CPC分类号： A61K31/10 , A61K9/08 , A61K9/1075 , A61K31/192 , A61K47/22 , A61K47/34 , A61K2300/00
摘要： An aqueous pharmaceutical solution composition comprising between about 20 mg/ml to about 100 mg/ml of a radioprotective α,&bgr;-unsaturated aryl sulfone, a cosolvent comprising polyethylene glycol (PEG), polypropylene glycol, polyglycerol, DMA, propylene glycol, glycerol, ethanol, sorbitol, isopropyl alcohol, or a combination thereof in an amount between about 25% and about 90% w/v, and a water soluble Vitamin E derivative, wherein the composition has a pH within the range of about 7.0 to about 9.5.
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公开(公告)号：EP2549867A4
公开(公告)日：2013-08-14
申请号：EP11760229
申请日：2011-03-24
发明人： KUMAR RAMESH , MANIAR MANOJ
CPC分类号： A61K31/10 , A61K9/0019
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4.发明公开FORMULATIONS FOR PARENTERAL ADMINISTRATION OF (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES 审中-公开（E）-2,6-二烷氧基甲硅烷基-4-取代苯乙烯苯并二苯并呋喃
公开(公告)号：EP2124569A4
公开(公告)日：2013-02-27
申请号：EP08724530
申请日：2008-01-16
发明人： BELL STANLEY C , MANIAR MANOJ
CPC分类号： A61K31/496 , A61K9/0019 , A61K47/02 , A61K47/10
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5.发明公开
公开(公告)号：EP2373993A4
公开(公告)日：2012-10-03
申请号：EP09835551
申请日：2009-12-14
发明人： RAMESH KUMAR
CPC分类号： A61K31/10 , G01N33/5014 , G01N2800/52
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6.发明授权AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS 有权氨基 - 取代的（E）-2,6-二DIALKOXYSTYRYL 4-取代BENZYLSULFONE用于治疗增殖性疾病
公开(公告)号：EP1487428B1
公开(公告)日：2011-09-21
申请号：EP03711347.9
申请日：2003-02-28
申请人： Temple University - Of The Commonwealth System of Higher Education , Onconova Therapeutics, Inc.
IPC分类号： A61K31/136 , C07C217/54 , C07C251/08 , C07C251/24
CPC分类号： C07D295/155 , C07C317/28 , C07D295/15
摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.
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7.发明授权AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS 有权氨基SULPHONANILIDE及其衍生物对增生性疾病的治疗
公开(公告)号：EP1534284B1
公开(公告)日：2011-07-27
申请号：EP03711348.7
申请日：2003-02-28
申请人： Temple University - Of The Commonwealth System of Higher Education , Onconova Therapeutics, Inc.
IPC分类号： A61K31/497 , A61K31/225 , A61K31/17 , A61K31/18 , C07C311/29 , C07C303/38 , C07C303/40 , C07C57/34 , C07C69/157 , C07C275/40 , C07D241/04
CPC分类号： C07C311/27 , C07C311/44
摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I): wherein:Ar, X, X1, g, R and R3 are as defined herein.
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8.发明公开
公开(公告)号：EP1578721A2
公开(公告)日：2005-09-28
申请号：EP02773744.4
申请日：2002-10-11
IPC分类号： C07D201/00
CPC分类号： C07D261/08 , C07C303/40 , C07D261/04 , C07C311/17
摘要： Provided are compounds, processes and synthetic intermediates useful for the preparation of compounds of the formula I and IX wherein R1 is selected from the group consisting of hydrogen, trihalomethyl, C¿1-?C6 alkyl and substituted or unsubstituted phenyl; Y is a group of the formula wherein R?2¿ is selected from the group consisting of C¿1?-C6 alkyl, C1-C6 alkanoylamino and amino; and R?5¿ is selected from the group consisting of hydrogen, amino, halogen, hydroxyl, nitro, C¿1?-C6 alkyl, C1-C6 alkoxy, carboxy, C1-C6 trihaloalkyl, cyano, phosphonato, and hydroxyalkyl; and Z is selected from the group consisting of substituted and unsubstituted aryl. Also provided are certain N-acylated analogs of compounds of the formula I and IX, and processes for their preparation.
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9.发明公开METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH $g(a), $g(b) UNSATURATED ARYL SULFONES 有权ALPHA，BETA不饱和芳砜的用于细胞毒性ON离子辐射保护与组织USE
公开(公告)号：EP1370253A2
公开(公告)日：2003-12-17
申请号：EP02733811.0
申请日：2002-02-28
IPC分类号： A61K31/10 , A61K31/275 , A61K31/435 , A61K31/425 , A61K31/40 , A61K31/35
CPC分类号： A61K31/435 , A61K31/10 , A61K31/275 , A61K31/35 , A61K31/40 , A61K31/425 , A61K41/00 , A61K2300/00
摘要： Pre-treatment with α, β unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective α, β unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the α, β unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of α, β unsatured arylsulfone.
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公开(公告)号：EP4433061A1
公开(公告)日：2024-09-25
申请号：EP22896785.7
申请日：2022-11-18
发明人： FRUCHTMAN, Steven , PARRIS, Matthew , GELDER, Mark
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： A61P35/00 , A61K31/519 , C07D471/04 , A61K31/4196 , A61K45/06
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