专利检索 ap:("Onconova Therapeutics, Inc.") AND inv:"REDDY, Ramana, M., V." 第 1 页

1.

发明公开
ALPHA, BETA-UNSATURATED SULFOXIDES FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译： α，β-不饱和亚砜增殖性疾病的治疗

公开(公告)号：EP1689706A2

公开(公告)日：2006-08-16

申请号：EP04816944.5

申请日：2004-11-08

申请人： Temple University of the Commonwealth System of Higher Education , Onconova Therapeutics, Inc

发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.

IPC分类号： C07C317/10 , A61K31/10

CPC分类号： C07C317/44 , C07C317/10 , C07C317/18 , C07C317/28 , C07D207/333 , C07D213/34 , C07D277/26 , C07D307/38 , C07D333/18

摘要： αβ-Unsaturated sulfoxides of Formula I: (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

2.

发明公开
AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译：氨基 - 取代的（E）-2,6-二DIALKOXYSTYRYL 4-取代BENZYLSULFONE用于治疗增殖性疾病

公开(公告)号：EP1487428A2

公开(公告)日：2004-12-22

申请号：EP03711347.9

申请日：2003-02-28

申请人： Temple University of the CommonwealthSystem of Higher Education , Onconova Therapeutics, Inc

发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.

IPC分类号： A61K31/136 , C07C217/54 , C07C251/08 , C07C251/24

CPC分类号： C07D295/155 , C07C317/28 , C07D295/15

摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.

3.

发明授权
AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译：氨基 - 取代的（E）-2,6-二DIALKOXYSTYRYL 4-取代BENZYLSULFONE用于治疗增殖性疾病

公开(公告)号：EP1487428B1

公开(公告)日：2011-09-21

申请号：EP03711347.9

申请日：2003-02-28

申请人： Temple University - Of The Commonwealth System of Higher Education , Onconova Therapeutics, Inc.

发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.

IPC分类号： A61K31/136 , C07C217/54 , C07C251/08 , C07C251/24

CPC分类号： C07D295/155 , C07C317/28 , C07D295/15

摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.

4.

发明授权
AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译：氨基SULPHONANILIDE及其衍生物对增生性疾病的治疗

公开(公告)号：EP1534284B1

公开(公告)日：2011-07-27

申请号：EP03711348.7

申请日：2003-02-28

申请人： Temple University - Of The Commonwealth System of Higher Education , Onconova Therapeutics, Inc.

发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.

IPC分类号： A61K31/497 , A61K31/225 , A61K31/17 , A61K31/18 , C07C311/29 , C07C303/38 , C07C303/40 , C07C57/34 , C07C69/157 , C07C275/40 , C07D241/04

CPC分类号： C07C311/27 , C07C311/44

摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I): wherein:Ar, X, X1, g, R and R3 are as defined herein.

5.

发明公开
PROCESSES FOR THE PREPARATION OF SUBSTITUTED ISOXAZOLES AND 2-ISOXAZOLINES 审中-公开
标题翻译：用于生产取代异恶唑和2-异恶唑啉

公开(公告)号：EP1578721A2

公开(公告)日：2005-09-28

申请号：EP02773744.4

申请日：2002-10-11

申请人： Onconova Therapeutics, Inc.

发明人： REDDY, Ramana, M., V. , BELL, Stanley, C.

IPC分类号： C07D201/00

CPC分类号： C07D261/08 , C07C303/40 , C07D261/04 , C07C311/17

摘要： Provided are compounds, processes and synthetic intermediates useful for the preparation of compounds of the formula I and IX wherein R1 is selected from the group consisting of hydrogen, trihalomethyl, C¿1-?C6 alkyl and substituted or unsubstituted phenyl; Y is a group of the formula wherein R?2¿ is selected from the group consisting of C¿1?-C6 alkyl, C1-C6 alkanoylamino and amino; and R?5¿ is selected from the group consisting of hydrogen, amino, halogen, hydroxyl, nitro, C¿1?-C6 alkyl, C1-C6 alkoxy, carboxy, C1-C6 trihaloalkyl, cyano, phosphonato, and hydroxyalkyl; and Z is selected from the group consisting of substituted and unsubstituted aryl. Also provided are certain N-acylated analogs of compounds of the formula I and IX, and processes for their preparation.

6.

发明授权
ALPHA, BETA-UNSATURATED SULFOXIDES FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译： ALPHA，BETA-UNGESÄTTIGTESULFOXIDE ZUR BEHANDLUNG VON PROLIFAATIVEN ERKRANKUNGEN

公开(公告)号：EP1689706B1

公开(公告)日：2017-01-11

申请号：EP04816944.5

申请日：2004-11-08

申请人： Temple University - Of The Commonwealth System of Higher Education , Onconova Therapeutics, Inc.

发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.

IPC分类号： C07C317/10 , A61K31/10 , C07D333/18 , C07C317/18 , C07C317/28 , C07C317/44 , C07D207/333 , C07D277/26 , C07D213/34 , C07D307/38

CPC分类号： C07C317/44 , C07C317/10 , C07C317/18 , C07C317/28 , C07D207/333 , C07D213/34 , C07D277/26 , C07D307/38 , C07D333/18

7.

发明公开
AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS 有权
标题翻译：氨基SULPHONANILIDE及其衍生物对增生性疾病的治疗

公开(公告)号：EP1534284A2

公开(公告)日：2005-06-01

申请号：EP03711348.7

申请日：2003-02-28

申请人： Temple University of the CommonwealthSystem of Higher Education , Onconova Therapeutics, Inc

发明人： REDDY, Premkumar, E. , REDDY, Ramana, M., V. , BELL, Stanley, C.

IPC分类号： A61K31/497 , A61K31/225 , A61K31/17 , A61K31/18 , C07C311/29 , C07C303/38 , C07C303/40 , C07C57/34 , C07C69/157 , C07C275/40 , C07D241/04

CPC分类号： C07C311/27 , C07C311/44

摘要： Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I): wherein:Ar, X, X1, g, R and R3 are as defined herein.