公开(公告)号：EP1539813A2

公开(公告)日：2005-06-15

申请号：EP03757887.9

申请日：2003-09-23

Applicant: ORIDIS BIOMED Forschungs- und Entwicklungs GmbH

Inventor： GUELLY, Christian ,  BUCK, Charles ,  ZATLOUKAL, Kurt

IPC: C07K14/47 ,  C07K19/00 ,  C12N15/12 ,  C12N15/62 ,  C12N5/00 ,  A01K67/027 ,  C07K16/18 ,  G01N33/68 ,  G01N33/53 ,  C12Q1/68 ,  A61K38/17 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/021 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/178

Abstract: The invention relates to polypeptides and nucleic acids encoding these and to their use for the diagnosis, prevention and/or treatment of liver disorders and neoplastic disorders, especially cancer of the liver and other epithelial tissues, benign liver neoplasms such as adenoma and other proliferative liver disorders such as focal nodular hyperplasia (FNH) and cirrhosis. The invention further relates to methods of diagnosing and treating these disorders.

公开(公告)号：EP1832585A1

公开(公告)日：2007-09-12

申请号：EP06110948.4

申请日：2006-03-10

Applicant: Oridis Biomed Forschungs- und Entwicklungs GmbH

Inventor： Otte, Marcus

IPC: C07D417/04 ,  A61K31/426

CPC classification number: C07D417/04 ,  C07D417/14

Abstract: The invention relates to compounds of formula (1)

wherein R 1 represents optionally substituted amino, optionally substituted phenyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted phenyl- or heteroaryl-alkyl, optionally substituted phenylaminocarbonyl-alkoxyalkyl or an alkenyl group as defined in the specification. These compounds are useful for the treatment of hyperproliferative diseases, in particular, liver cancers.

Abstract translation: 本发明涉及式（1）的化合物，其中R 1表示任选取代的氨基，任选取代的苯基，任选取代的杂芳基，任选取代的杂环基，任选取代的苯基或杂芳基 - 烷基，任选取代的苯基氨基羰基 - 烷氧基烷基或如所定义的烯基 在规范中。 这些化合物可用于治疗过度增生性疾病，特别是肝癌。

公开(公告)号：EP1832586A1

公开(公告)日：2007-09-12

申请号：EP06110952.6

申请日：2006-03-10

Applicant: Oridis Biomed Forschungs- und Entwicklungs GmbH

Inventor： Otte, Marcus

IPC: C07D417/04 ,  C07D277/10 ,  C07D211/32 ,  A61K31/427 ,  A61K31/4418 ,  A61P1/16 ,  A61P1/18

CPC classification number: C07D417/14 ,  C07D211/32 ,  C07D277/10 ,  C07D417/04 ,  C07D417/06

Abstract: The present invention relates to the use of piperidinyl-thiazole derivatives of formula (1)

in the treatment and prevention of diseases of liver and the pancreas, wherein the substituents have the meanings explained in the description, and to particular compounds suitable for this use and to pharmaceutical compositions containing them.

Abstract translation: 本发明涉及式（1）的哌啶基 - 噻唑衍生物在治疗和预防肝脏和胰腺疾病中的用途，其中取代基具有说明书中解释的含义，以及适用于该用途的特定化合物 含有它们的药物组合物。

公开(公告)号：EP1765413A2

公开(公告)日：2007-03-28

申请号：EP05775873.2

申请日：2005-07-12

Applicant: Oridis Biomed Forschungs- und Entwicklungs GmbH

Inventor： FRÖHLICH, Eleonore ,  KVIETIKOVA, Ivica ,  ZATLOUKAL, Kurt ,  SCHATZ, Gottfried ,  DENK, Helmut ,  STUMPTNER, Cornelia ,  BUCK, Charles

IPC: A61K47/48 ,  A61P5/00 ,  A61P35/00

CPC classification number: A61K47/54

Abstract: The present invention relates to the use of a mitochondrially targeted antioxidant, e.g. de­rivatives of vitamin E, coenzyme Q10 or a glutathione peroxidase mimetic, in the treatment and prevention of liver diseases and/or epithelial cancers. The present invention also relates to pharmaceutical compositions containing the antioxi­dant(s) intended for such use. Furthermore the invention relates to the manufacture of me­dicaments containing the antioxidant(s) useful for such prevention and treatment.

公开(公告)号：EP1563273A1

公开(公告)日：2005-08-17

申请号：EP03757521.4

申请日：2003-10-30

Applicant: Oridis Biomed Forschungs- und Entwicklungs GmbH

Inventor： SCHNETZ, Guntram ,  REDL, Heinz ,  ZATLOUKAL, Kurt

IPC: G01N1/36 ,  C12M1/26

CPC classification number: G01N1/36 ,  G01N1/08

Abstract: The invention relates to a method and a device for manipulating samples, in particular tissue samples, comprising at least one needle (2) for punching holes (34) in sample carriers (4), at least one additional needle (3) for punching samples out of preparations (5) and a device for detecting the position of the surface of the sample carriers (4) or preparations (5). According to the invention, the device for detecting the position of the surface of the sample carriers (4) or preparations (5) is formed by suction lines (9) that open into the needles (2, 3). Said lines are connected to a unit (10) for generating a negative pressure and a unit (11) for detecting a negative pressure, in such a way that the approach of the needles (2, 3) towards the surface of the sample carrier (4) or preparation (5) can be detected by means of the corresponding negative pressure. The inventive device is also equipped with a drive unit (7) for displacing the needles (2, 3) relative to the sample carrier (4) or preparation (5) from the detected position of the surface to a predefined punching depth (D).

公开(公告)号：EP1556476A2

公开(公告)日：2005-07-27

申请号：EP03769021.1

申请日：2003-10-30

Applicant: Oridis Biomed Forschungs- und Entwicklungs GmbH

Inventor： SCHNETZ, Guntram ,  REDL, Heinz ,  ZATLOUKAL, Kurt

IPC: C12M1/16 ,  G01N1/31 ,  G02B21/32

CPC classification number: G01N1/08 ,  G01N1/31 ,  G01N1/36 ,  G01N2001/288 ,  G02B21/32 ,  G02B21/365

Abstract: The invention relates to a method and a device for manipulating samples, in particular tissue samples, comprising at least one needle (3) for punching samples out of preparations (5), in particular at defined points on prepared tissue sections and a control device (13) for controlling the needle (3). The aim of the invention is to provide a method and a device, which allow a simple selection of desired punching positions on the preparations (5) and enable a rapid, simple and automatic manipulation of samples. To achieve this, the device is equipped with a camera (14) for capturing images of the surface of the preparations (5), in addition to a unit for superimposing the captured images of the preparations (5) on digital, microscopic images of sections of said preparations (5) that are stored in a memory, a display (12) for reproducing the superimposed images and a unit for applying markings to determine the defined punching positions, said unit being connected to the control device (13).