摘要:
An apparatus for processing fluid includes a vessel provided with a sidewall including a passage and at least partially defining an interior compartment. A drain tube positioned in the interior compartment may drain fluid through the passage in the sidewall. The drain tube may be angled, and arranged such that the end in the interior compartment may be adapted for movement as the result of manipulation of a structure, such as a coupler, external to the interior compartment. Accordingly, the drain tube may be positioned along the sidewall at a reference point for movement between a first position for draining fluid above the reference point and a second position for draining fluid below the reference point. An indexing feature may also be provided for incrementally adjusting the position of the drain tube, along with an associated tool to facilitate the adjustment. Related methods are also disclosed.
摘要:
A manner of providing an improved fluid processing arrangement, and bioprocessing in particular, is adapted to agitate the fluid, and also simultaneously provide for the distribution of gas throughout the fluid in order to maintain desirable processing conditions (such as an increased level of dissolved oxygen, in the case of biological applications). In some embodiments, the mixing would be completed without necessitating the use of an external drive motor or the like, such as by using a fluid-driven mixer. Overall, use of the improved arrangement leads to a simplification of the fluid processing operation with improved results and a concomitant reduction in the expense associated with such use.
摘要:
In one aspect, an apparatus for bioprocessing using a liquid comprises an at least partially flexible vessel for receiving the liquid, and a filter adapted for moving within the liquid. An agitator may also be provided for agitating the liquid, and may be connected to the mixer. The mixer may spin or may not spin about an axis of rotation.
摘要:
In one aspect, a system for use in processing a fluid comprises a reservoir for holding the fluid and one or more bioreactors for receiving the fluid from the reservoir. One or more sensors are provided for sensing one or more parameters of the fluid, and corresponding control measures may be initiated. Regulators may also be provided for regulating various parameters of the fluid processing operation. Related systems and methods are also disclosed.
摘要:
A selectively closeable drain connector includes a hollow plunger moveable relative to an aperture-defining drain flange. The connector includes two circumferential seals between the plunger and the flange, and includes at least one passage disposed between the seals leading to a hollow interior. The drain connector may be joined to a processing bag and/or tank to form a substance processing receptacle.
摘要:
A recipient for cell cultivation having an inner compartment adapted for cell growth, in one embodiment, an outer tubular wall extends in a longitudinal direction and delimits an outer boundary of the inner compartment in a radial direction. First and second ends delimit the inner compartment at the first respectively the second outer end of the outer tubular wail. A fixed packing in the inner compartment comprises a packing, such as a fiber matrix. Additional embodiments and related methods are also disclosed.
摘要:
Bioprocessing vessel intended for receiving a fluid, comprising a bag (10) capable of receiving and holding the fluid, the bag having a rigid receiver (200) facing an interior, and an at least translucent tube (G) having a closed end for insertion through the receiver and in communication with the interior.
摘要:
Bioprocessing vessel intended for receiving a fluid, comprising a bag (10) capable of receiving and holding the fluid, the bag having a rigid receiver (200) facing an interior, and an at least translucent tube (G) having a closed end for insertion through the receiver and in communication with the interior.
摘要:
Bioprocessing vessel intended for receiving a fluid, comprising a bag (10) capable of receiving and holding the fluid, the bag having a rigid receiver (200) facing an interior, and an at least translucent tube (G) having a closed end for insertion through the receiver and in communication with the interior.