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公开(公告)号：EP1208133A1
公开(公告)日：2002-05-29
申请号：EP00947874.4
申请日：2000-06-23
申请人： Plank, Christian , Finsinger, Dirk
发明人： Plank, Christian , Finsinger, Dirk
IPC分类号： C08G65/329 , C08G65/333 , A61K48/00 , C12N15/87 , A61K47/48
CPC分类号： C12N15/87 , A61K47/6935 , A61K48/00 , C08G65/329 , C08G65/333 , C08G65/33396
摘要： The invention relates to copolymers that are obtained from an amphiphilic polymer, preferably polyethylene glycol, and a charged effector molecule, especially a peptide or peptide derivative. The invention also relates to nucleic acid complexes for use as non-viral vectors in gene therapy in which nucleic acid is condensed with a polycation and which contain the charged copolymer bound to their surface.
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公开(公告)号：EP1198489B1
公开(公告)日：2004-04-28
申请号：EP00936907.5
申请日：2000-06-21
IPC分类号： C08G65/329 , C08G65/333 , A61K48/00 , C12N15/87 , A61K47/48
CPC分类号： C12N15/87 , A61K47/59 , A61K47/645 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/00 , C08G65/329 , C08G65/333 , C08G65/33396
摘要： The invention relates to combinations of a carrier and a complex, which consists of a nucleic-acid molecule and a copolymer. Said copolymer consists of an amphiphilic polymer, preferably polyethylene glycol and a charged effector molecule, in particular, a peptide or peptide derivative. The invention also relates to the use of the combinations for transferring nucleic acid molecules into cells.
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3.发明公开POLYPEPTIDES COMPRISING MULTIMERS OF NUCLEAR LOCALIZATION SIGNALS OR OF PROTEIN TRANSDUCTION DOMAINS AND THEIR USE FOR TRANSFERRING MOLECULES INTO CELLS 审中-公开多肽，核SIGNALLOKALISIERUNGS-的或者多聚蛋白包传输域及其用于传送生物分子在细胞
公开(公告)号：EP1235914A2
公开(公告)日：2002-09-04
申请号：EP00988753.0
申请日：2000-11-23
IPC分类号： C12N15/62 , C07K7/00 , C07K14/005 , C07K14/435 , C12N15/52 , C12N15/85 , C12N15/87 , A61K38/17
CPC分类号： C07K14/005 , A61K47/6425 , C07K2319/00 , C12N15/62 , C12N2710/22022 , C12N2740/16322
摘要： Described are polypeptides comprising at least two peptide monomers comprising a nuclear localization sequence or a protein transduction domain and their use for transferring molecules into eukaryotic cells, as well as pharmaceutical compositions comprising the described polypeptides and processes for transferring molecules into eukaryotic cells.
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4.发明公开KOMBINATIONEN ZUR EINFÜHRUNG VON NUCLEINSÄUREN IN ZELLEN 有权在ZELLEN的KOMBINATIONEN ZUREINFÜHRUNGVONNUCLEINSÄUREN
公开(公告)号：EP1198489A1
公开(公告)日：2002-04-24
申请号：EP00936907.5
申请日：2000-06-21
IPC分类号： C08G65/329 , C08G65/333 , A61K48/00 , C12N15/87 , A61K47/48
CPC分类号： C12N15/87 , A61K47/59 , A61K47/645 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/00 , C08G65/329 , C08G65/333 , C08G65/33396
摘要： The invention relates to combinations of a carrier and a complex, which consists of a nucleic-acid molecule and a copolymer. Said copolymer consists of an amphiphilic polymer, preferably polyethylene glycol and a charged effector molecule, in particular, a peptide or peptide derivative. The invention also relates to the use of the combinations for transferring nucleic acid molecules into cells.
摘要翻译： 描述了载体和由核酸分子和共聚物组成的复合物的组合，其中共聚物由两亲聚合物，优选聚乙二醇和带电荷的效应分子，特别是肽或肽衍生物组成，以及它们 用于将核酸分子转移到细胞中。
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公开(公告)号：EP1297169A2
公开(公告)日：2003-04-02
申请号：EP01949436.8
申请日：2001-06-26
CPC分类号： C12N15/1013 , A61K48/00 , A61K48/0025 , A61K48/0041 , A61K48/0083 , C12N13/00 , C12N15/86 , C12N15/87 , C12N15/88 , C12N2710/10343 , C12N2740/13043
摘要： Described is a method for transfecting a cell comprising bringing a complex comprising vector(s) and magnetic particle(s) in contact with a cell by applying a magnetic field and methods of treatment using said method. Furthermore, described is such a complex as well as methods for making it. Finally, pharmaceutical compositions, uses of such complexes and a kit are described. The method described is particularly useful where automatizable high-throughput transfection is required for large scale screening processes.
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