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    MAGNETIC-BASED SYSTEMS
    1.
    发明公开
    MAGNETIC-BASED SYSTEMS 审中-公开

    公开(公告)号：EP3443916A2

    公开(公告)日：2019-02-20

    申请号：EP18191071.2

    申请日：2013-05-13

    申请人： Pulse Therapeutics, Inc.

    发明人： CREIGHTON, Francis M. ,  SABO, Michael ,  NULL, Christopher ,  EPPLIN, Gerard ,  WACHTMAN, James Christopher

    IPC分类号： A61B17/3207 ,  A61N2/12 ,  A61B34/30 ,  A61B34/20 ,  A61B34/10 ,  A61B17/22

    摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.

    MAGNETIC-BASED SYSTEMS
    3.
    发明公开
    MAGNETIC-BASED SYSTEMS 审中-公开

    公开(公告)号：EP3443916A3

    公开(公告)日：2019-04-24

    申请号：EP18191071.2

    申请日：2013-05-13

    申请人： Pulse Therapeutics, Inc.

    发明人： CREIGHTON, Francis M. ,  SABO, Michael ,  NULL, Christopher ,  EPPLIN, Gerard ,  WACHTMAN, James Christopher

    IPC分类号： A61B17/3207 ,  A61N2/12 ,  A61B34/30 ,  A61B34/20 ,  A61B34/10 ,  A61B17/22

    摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.

    MAGNETIC-BASED SYSTEMS AND METHODS FOR MANIPULATION OF MAGNETIC PARTICLES
    4.
    发明公开
    MAGNETIC-BASED SYSTEMS AND METHODS FOR MANIPULATION OF MAGNETIC PARTICLES 有权
    MAGNETBASIERTE SYSTEME UND VERFAHREN ZUR MANIPULATION MAGNETISCHER TEILCHEN

    公开(公告)号：EP2849657A1

    公开(公告)日：2015-03-25

    申请号：EP13790201.1

    申请日：2013-05-13

    申请人： Pulse Therapeutics, Inc.

    发明人： CREIGHTON, Francis, M. ,  SABO, Michael ,  NULL, Christopher ,  EPPLIN, Gerard ,  WACHTMAN, James Christopher

    IPC分类号： A61B17/22 ,  A61N2/10 ,  A61M5/142 ,  A61B8/00

    CPC分类号： A61B17/3207 ,  A61B17/320758 ,  A61B34/25 ,  A61B34/30 ,  A61B34/73 ,  A61B2017/00345 ,  A61B2017/00411 ,  A61B2017/22082 ,  A61B2017/320004 ,  A61N2/004 ,  A61N2/12

    摘要： Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.

    摘要翻译： 一些实施例提供一种用于使用远程放置的产生磁场的定子在脉管系统中外部操纵磁性纳米颗粒的系统。 在一个实施例中，系统和方法涉及使用基于永磁体或电磁场产生定子源的流体介质中的磁性纳米颗粒的控制。 这种系统可用于增加治疗剂在诸如人类循环系统的流体介质中的扩散，其可导致循环系统中的流体阻塞物（例如血管闭塞）的实质性清除，导致血流量增加。 提供了具有非专门化学涂层的磁性纳米颗粒，其有助于使用者在输注之前与化学成分相关联。 系统被提供用于将一致的输注质量的磁性纳米颗粒递送给患者。

    MAGNETOMOTIVE STATOR SYSTEM AND METHODS FOR WIRELESS CONTROL OF MAGNETIC ROTORS
    5.
    发明公开
    MAGNETOMOTIVE STATOR SYSTEM AND METHODS FOR WIRELESS CONTROL OF MAGNETIC ROTORS 审中-公开
    MAGNETOMOTORISCHES STATORSYSTEM UND VERFAHREN ZUR DRAHTLOSEN STEUERUNG MAGNETISCHER ROTOREN

    公开(公告)号：EP2496302A4

    公开(公告)日：2017-07-26

    申请号：EP10827657

    申请日：2010-11-02

    申请人： PULSE THERAPEUTICS INC

    发明人： CREIGHTON FRANCIS M ,  RITTER ROGERS C

    IPC分类号： A61B34/00 ,  A61B17/22 ,  H01F7/02

    CPC分类号： A61K41/00 ,  A61B17/22 ,  A61B17/22012 ,  A61B34/73 ,  A61B2017/00876 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2034/733 ,  A61K9/0019 ,  A61K38/482 ,  A61K38/484 ,  A61K47/6941 ,  A61N2/004 ,  A61N2/02 ,  A61N2/06 ,  B82Y5/00 ,  C12Y304/21007 ,  C12Y304/21068 ,  H01F7/0273 ,  Y10S977/811 ,  Y10S977/905 ,  Y10S977/909

    摘要： The present invention relates to a system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator. In one aspect, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.

    摘要翻译： 一些实施例提供了一种使用远程放置的产生磁场的定子来外部操纵脉管系统中的磁性纳米颗粒的系统。 在一个方面，该系统和方法涉及使用基于永磁体或电磁场的定子源对流体介质中的磁性纳米粒子进行控制。 这样的系统可用于增加治疗剂在流体介质（例如人体循环系统）中的扩散，其可导致循环系统中的流体障碍物（例如血管阻塞）的实质清除，导致血流增加。

    MAGNETIC-BASED SYSTEMS
    8.
    发明公开
    MAGNETIC-BASED SYSTEMS 审中-公开

    公开(公告)号：EP4302821A2

    公开(公告)日：2024-01-10

    申请号：EP23212094.9

    申请日：2013-05-13

    申请人： Pulse Therapeutics, Inc.

    发明人： CREIGHTON, Francis M. ,  SABO, Michael ,  NULL, Christopher ,  EPPLIN, Gerard ,  WACHTMAN, James Christopher

    IPC分类号： A61N2/12

    摘要： The application provides a therapeutic system comprising a plurality of magnetic rotors, a magnet having a magnetic field and a gradient for controlling the magnetic rotors in a vasculature of a circulatory system, and a controller for positioning and rotating the magnetic field and the gradient in a manner to traverse the magnetic rotors with respect to a therapeutic target in the circulatory system, wherein the system can be operated in a vortexing mode, in which the magnetic field oscillates between a clockwise and a counter-clockwise direction of rotation.