公开(公告)号：EP1891206A1

公开(公告)日：2008-02-27

申请号：EP06747492.4

申请日：2006-06-02

申请人： Samyang Genex Corporation

发明人： KIM, Jin-Ah ,  KIM, Chang-Heon ,  SONG, Jai-Young ,  CHOI, Ho-Joon

IPC分类号： C12N5/02 ,  C12N5/04

CPC分类号： C12N5/0025 ,  C12N1/38 ,  C12P17/02

摘要： The present invention relates to a method of producing secondary metabolites with a high yield using plant cell culture, and a medium for the production of secondary metabolites. More specifically, the method of the present invention is characterized in that the plant cell culture is conducted by adding a saccharide mixture to the culture medium as a carbon source, to increase the productivity of the secondary metabolites. For example, the present invention establishes the method of increasing the productivity of secondary metabolites and shortening the culture time by the use of the mixture of glucose and fructose in the plant cell culture, thereby contributing in producing useful secondary metabolites on an industrial scale using plant cell culture.

公开(公告)号：EP2658875A1

公开(公告)日：2013-11-06

申请号：EP11853199.5

申请日：2011-11-23

申请人： Samyang Genex Corporation

发明人： HONG, Pil Nam ,  KOH, Chang Heon

IPC分类号： C08B31/10 ,  C08B30/12

CPC分类号： C08B31/10 ,  C08B30/12 ,  C08B31/12

摘要： The present invention relates to a method for preparing hydroxyalkyl starch. The method for preparing hydroxyalkyl starch comprises the steps of hydrolyzing starch, reducing the hydrolyzed starch, and substituting the reduced starch with hydroxyalkyl group in a dry process.

公开(公告)号：EP2376646A2

公开(公告)日：2011-10-19

申请号：EP09838447.2

申请日：2009-11-26

申请人： Samyang Genex Corporation ,  Genotech Co., Ltd

发明人： CHO, Jin Suk ,  YOON, Jong Won ,  CHOI, Eun Soo ,  KIM, Jeong Min ,  CHOI, Ho Joon ,  KIM, Sung Hag ,  KIM, Seong Kyu ,  KIM, Jae Jong

IPC分类号： C12P19/44 ,  C12P1/04 ,  A61P31/04

CPC分类号： C12P19/60 ,  C07K9/008

摘要： Provided is a process for purifying a vancomycin wet body, comprising: dissolving a wet body obtained from a microorganism-fermented solution containing vancomycin into a water soluble solvent to a concentration of about 1 to 40 g/L and carrying out reverse osmosis filtration; and carrying out lyophilization of the filtered vancomycin. The process for purifying a vancomycin wet body provides high-purity vancomycin, while avoiding degradation of stability during a drying step.

公开(公告)号：EP1973894A2

公开(公告)日：2008-10-01

申请号：EP06812378.5

申请日：2006-11-02

申请人： Samyang Genex Corporation

发明人： PYO, Sang-Hyun ,  CHO, Jin-Suk ,  KIM, Moon-Suk ,  SONG, Bong-Kyu ,  CHOI, Ho-Joon

IPC分类号： C07D305/14

CPC分类号： C07D305/14

摘要： This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hydrated crystalline docetaxel can be produced with a high yield by using a solvent precipitation method, colloid formation method, etc.

公开(公告)号：EP1899455A1

公开(公告)日：2008-03-19

申请号：EP06769139.4

申请日：2006-06-30

申请人： Samyang Genex Corporation

发明人： KIM, Chang-Heon 104-602 Yudeungmauel Apt. ,  CHOI, Ho-Joon 6-304 Jugong Apt. ,  SONG, Jai-Young 201-506 Gukhwa Apt. ,  KIM, Jin-Ah 103-406 Sejong Apt.

IPC分类号： C12N5/00 ,  C12N5/04

CPC分类号： C12N5/04 ,  A01H4/00 ,  A01H4/005 ,  C12P7/42

摘要： The present invention relates to a method of producting corosolic acid by using plant cells that produce corosolic acid. More particularly, the present invention relates to a method of producting corosoilic acid by using plant cell suspension cultures comprising the steps of: inducing a callus from a tissue of a plant producing corosolic acid; preparing a cell line capable of being cultured in liquid culture medium from the induced callus; culturing the cell line in a suspension culture; and isolating corosolic acid from the culture solution. The present invention has advantage of maximizing productivity by utilizing two-stage culture, treatment with inducing agent, and high cell-density culture in the suspension culture of plant cells producing corosolic acid.

公开(公告)号：EP1742665A1

公开(公告)日：2007-01-17

申请号：EP05739818.2

申请日：2005-05-06

申请人： Samyang Genex Corporation

发明人： YI, Yil-Woong ,  LEE, Sa-Won Daerimdoorae Apt. ,  YU, Jeong-Il ,  CHANG, Dong-Hoon ,  SEO, Min-Hyo ,  KANG, Hye-Won ,  KIM, Jae-Hong

IPC分类号： A61K47/34 ,  C08G63/91

CPC分类号： C08G63/912 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/19 ,  A61K9/5153 ,  A61K47/34 ,  C08G2261/126 ,  C08L53/00 ,  C08L67/00 ,  C08L67/04 ,  C08L87/005 ,  C08L101/06 ,  C08L2666/02

摘要： Delivery system for bioactive agents on the basis of a polymeric drug carrier formed from compositions comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block having a terminal hydroxyl group substituted with a tocopherol or cholesterol group, and a polylactic acide derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or trivalent metal ion,which is obtained by adding the di- or trivalent metal ion to the polymeric composition.

公开(公告)号：EP2960242A1

公开(公告)日：2015-12-30

申请号：EP14754881.2

申请日：2014-02-21

申请人： Samyang Genex Corporation

发明人： RYU, Hoon ,  JUNG, Young Jae ,  KIM, Jin Kyung ,  KYUNG, Do Hyun ,  PARK, Hyuk Min ,  CHO, Seong Ho

IPC分类号： C07D493/04 ,  B01J31/10

CPC分类号： B01J31/10 ,  C07D493/04

摘要： The present invention relates to a method for producing an anhydrosugar alcohol and, more specifically, to a method for producing an anhydrosugar alcohol which, when the step of subjecting a hydrogenated sugar to a dehydration reaction in a reactor so as to convert same to an anhydrosugar alcohol is performed, allows the hydrogenated sugar to be continuously introduced into the reactor and the produced anhydrosugar alcohol to be continuously discharged out of the reactor while the dehydration reaction is carried out, also prevents a reaction mixture from circulating inside and outside the reactor while the dehydration reaction is carried out, and thereby can significantly improve production efficiency compared with a conventional process adopting a batch or semi-batch-type dehydration reaction and thus can be appropriately applied particularly to a large-scale anhydrosugar alcohol production process.

摘要翻译： 本发明涉及一种方法，用于在脱水糖醇生产，并且更具体地，涉及一种用于在脱水糖醇生产，当经受氢化糖在反应器中脱水反应的步骤，以同样的转换为在脱水 醇进行，允许该氢化糖被连续地引入到反应器中和所产生的脱水糖醇被连续排出反应器的同时脱水反应进行，使得来自内部循环并且当在反应器外防止反应混合物 脱水反应进行，从而可以显着提高生产效率与常规方法采用间歇或半间歇式脱水反应，从而关位适当地应用于特别是涉及一种大型脱水糖醇的生产工艺相比。

公开(公告)号：EP2933256A1

公开(公告)日：2015-10-21

申请号：EP13862769.0

申请日：2013-12-12

申请人： Samyang Genex Corporation

发明人： RYU, Hoon ,  JUNG, Young Jae ,  KIM, Jin Kyung ,  KYUNG, Do Hyun ,  PARK, Hyuk Min ,  CHO, Seong Ho

IPC分类号： C07D493/04 ,  B01J23/755

CPC分类号： C07C29/132 ,  B01J31/0225 ,  B01J2231/641 ,  B01J2231/643 ,  C07C29/34 ,  C07C31/18 ,  C07C31/26

摘要： The present invention relates to a method for preparing an anhydrosugar alcohol using hydrol (namely, a crystalline mother liquor remaining after obtaining crystalline glucose from a crude glucose liquor). More particularly, the present invention relates to a method for preparing an anhydrosugar alcohol in a method for performing a dehydration reaction on the hydrogenated sugar so as to convert the hydrogenated sugar to an anhydrosugar alcohol, wherein the method for preparing an anhydrosugar alcohol is configured to use, as at least a portion of the hydrogenated sugar, the product obtained from the hydrogenation of the hydrol which is a by-product or waste generated during the production of glucose, thus relatively lowering the cost for a material as compared with a case of using a high purity raw material (for example, high purity sorbitol), to thus improve economical advantages, and further reduce the amount of waste and cost for disposal of the waste during the production of glucose.

摘要翻译： 本发明涉及使用水解制备脱水葡萄糖醇的方法（即从粗葡萄糖液中获得结晶葡萄糖后残留的结晶母液）。 更具体地说，本发明涉及一种在氢化糖上进行脱水反应的方法制备脱水葡萄糖醇的方法，以将氢化糖转化为脱水葡萄糖醇，其中制备脱水葡萄糖醇的方法被配置为 使用作为氢化糖的至少一部分的产物，其由在生产葡萄糖时产生的副产物或废物的氢化物的氢化获得，从而相对于材料的成本相对降低了材料的成本 使用高纯度原料（例如高纯度山梨糖醇），从而提高经济效益，进一步减少废弃物在生产葡萄糖过程中废弃物的处理量和成本。

公开(公告)号：EP2918572A1

公开(公告)日：2015-09-16

申请号：EP13853737.8

申请日：2013-11-06

申请人： Samyang Genex Corporation

发明人： RYU, Hoon ,  JUNG, Young Jae ,  KIM, Jin Kyung ,  KYUNG, Do Hyun ,  PARK, Hyuk Min ,  CHO, Seong Ho

IPC分类号： C07C29/80 ,  C07C29/94 ,  C07C31/26 ,  B01J19/24

CPC分类号： C07D493/04 ,  B01J19/24 ,  C07C29/80 ,  C07C29/94 ,  C07C31/26

摘要： The present invention relates to a technique for preparing an anhydrosugar alcohol using hydrogenated sugar as a raw material and, more specifically, to a technique for preparing a high-purity anhydrosugar alcohol by adding an acid to hydrogenated sugar (for example, hexitol) to convert same to an anhydrosugar alcohol, then distilling the converted liquid, and crystallizing the distilled liquid in a solvent, the technique removing a crystallization solvent from a crystallization mother liquor generated during a crystallization step and then introducing the resultant product together with the distilled liquid and the converted liquid into a distillation step, thereby being capable of improving the total distillation yield of the anhydrosugar alcohol, improving distillation efficiency by improving the mobility of a distillate, and further reducing the amount of generated waste and treatment costs and thus highly efficiently preparing the high-purity anhydrosugar alcohol at reduced costs.

摘要翻译： 本发明涉及一种技术，用于制备使用氢化糖作为原料，并且更具体地涉及脱水糖醇，一种技术用于制备高纯度的无水糖醇加入到酸氢化糖（例如，己糖醇），以转换 同样在脱水糖醇，然后蒸馏该转换后的液体，并在溶剂中结晶化馏出液，该技术除去结晶过程中的结晶化步骤中产生的结晶母液的溶剂，然后与馏出液和所述引入所得产品一起 转换液体进入蒸馏步骤，从而能够提高脱水糖醇的总蒸馏收率的，由改进的馏出物的流动性提高蒸馏效率，并进一步降低产生的废物和治疗费用的量，从而高效地制备高 - 纯度，同时降低成本脱水糖醇。

公开(公告)号：EP2848601A1

公开(公告)日：2015-03-18

申请号：EP13788148.8

申请日：2013-05-09

申请人： Samyang Genex Corporation

发明人： JUNG, Young Jae ,  KIM, Jin Kyung ,  KYUNG, Do Hyun ,  RYU, Hoon

IPC分类号： C07C29/08 ,  C07C31/26 ,  C07H1/00

CPC分类号： C07D493/04 ,  C07C29/08 ,  C07C31/26

摘要： The present invention relates to a production method for an anhydro sugar alcohol having a markedly reduced ion content and improved colour characteristics, and, more specifically, relates to a method for producing an anhydrous sugar alcohol having a markedly reduced ion content, markedly lowered electrical conductivity and improved colour characteristics, which is obtained by subjecting hydrogenated sugar (sugar alcohol) to a dehydration reaction and thereby converting same to an anhydrous sugar alcohol and then subjecting distilled water, which has been isolated through a distillation step, to a decolourizing process using activated carbon, and subsequently bringing the resulting decolourized substance into contact with an ion exchange resin.

摘要翻译： 本发明涉及一种离子含量显着降低和颜色特性得到改善的脱水糖醇的生产方法，更具体地说，涉及一种离子含量显着降低，电导率显着降低的无水糖醇的生产方法 并通过使氢化糖（糖醇）发生脱水反应并由此将其转化为无水糖醇，然后将通过蒸馏步骤分离出的蒸馏水进行脱色过程而获得改进的颜色特性，所述脱色过程使用活化的 碳，随后使得到的脱色物质与离子交换树脂接触。