公开(公告)号：EP3134528A4

公开(公告)日：2017-12-06

申请号：EP15783597

申请日：2015-04-24

申请人： STRIKE BIO INC ,  BAYLOR COLLEGE MEDICINE

发明人： RAO DONALD ,  NEMUNAITIS JOHN ,  O'MALLEY BERT W ,  LONARD DAVID

IPC分类号： C12N15/113 ,  A61K48/00 ,  C12N5/10

CPC分类号： C12N15/1135 ,  A61K9/0019 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2310/531 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  A61K2300/00

摘要： The present invention includes compositions and methods for making and using a RNAi capable of reducing expression of two or more genes, comprising: a first RNAi molecule that reduces the expression of a first target gene; a second RNAi molecule that reduces the expression of the first or a second target gene; and optionally a third RNAi molecule that reduces the expression of the first, the second, or a third target gene, wherein the RNAi molecules reduce the expression level of, e.g., mutated KRAS, SRC-3, EGFR, PIK3, NCOA3, or ERalphal, and can be, e.g., miRNAs, shRNAs, or bifunctional shRNAs.

公开(公告)号：EP3134528A1

公开(公告)日：2017-03-01

申请号：EP15783597.6

申请日：2015-04-24

申请人： Strike Bio, Inc. ,  Baylor College of Medicine

发明人： RAO, Donald ,  NEMUNAITIS, John ,  O'MALLEY, Bert, W. ,  LONARD, David

IPC分类号： C12N15/113 ,  A61K48/00 ,  C12N5/10

CPC分类号： C12N15/1135 ,  A61K9/0019 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2310/531 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  A61K2300/00

摘要： The present invention includes compositions and methods for making and using a RNAi capable of reducing expression of two or more genes, comprising: a first RNAi molecule that reduces the expression of a first target gene; a second RNAi molecule that reduces the expression of the first or a second target gene; and optionally a third RNAi molecule that reduces the expression of the first, the second, or a third target gene, wherein the RNAi molecules reduce the expression level of, e.g., mutated KRAS, SRC-3, EGFR, PIK3, NCOA3, or ERalphal, and can be, e.g., miRNAs, shRNAs, or bifunctional shRNAs.

公开(公告)号：EP2507374B1

公开(公告)日：2016-12-07

申请号：EP10827443.2

申请日：2010-10-27

申请人： Strike Bio, Inc. ,  Baylor College of Medicine

发明人： NEMUNAITIS, John, J. ,  RAO, Donald ,  BRUNICARDI, Charles, F.

IPC分类号： C12N15/85 ,  C12N15/113

CPC分类号： C12N15/1135 ,  C12N15/85 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/51

公开(公告)号：EP2283131B1

公开(公告)日：2016-08-10

申请号：EP09739850.7

申请日：2009-04-30

申请人： Strike Bio, Inc.

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N15/10 ,  C12N15/63 ,  C12N15/64 ,  C12N15/11

CPC分类号： C12N15/1017 ,  B01D15/327 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  C07H21/04 ,  C12N9/2402 ,  C12N15/1003 ,  C12N15/101 ,  C12N15/63

公开(公告)号：EP2847333A4

公开(公告)日：2015-12-16

申请号：EP13788485

申请日：2013-05-09

申请人： STRIKE BIO INC

发明人： RAO DONALD ,  WANG ZHAOHUI ,  NEMUNAITIS JOHN J ,  SENZER NEIL

IPC分类号： C12N15/113 ,  A61K9/127 ,  A61K48/00 ,  A61P35/00 ,  B82Y5/00 ,  C12N15/85

CPC分类号： C12N15/1135 ,  A61K9/127 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2310/531 ,  C12N2310/533 ,  C12N2320/32 ,  C12N2320/50 ,  C12Q1/6897

摘要： The present invention includes compositions and methods for making and using a bifunctional shRNAs capable of reducing an expression of a K-ras gene, e.g., a mutated K-ras gene, wherein at least one target site sequence of the bifunctional RNA molecule is located within the K-ras gene and wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of K-ras.