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    ARTIFICIAL INVAPLEX
    2.
    发明公开
    ARTIFICIAL INVAPLEX 有权
    人工INVAPLEX

    公开(公告)号：EP2139514A1

    公开(公告)日：2010-01-06

    申请号：EP07754057.3

    申请日：2007-03-27

    申请人： The United States of America, as represented by the Secretary of the Army, Walter Reed Army Institute of Research

    发明人： OAKS, Edwin V. ,  TURBYFILL, Kevin R. ,  KAMINSKI, Robert W.

    IPC分类号： A61K39/02 ,  A61P31/04 ,  A61K39/112 ,  A61K39/108

    CPC分类号： A61K39/0283 ,  A61K39/39 ,  A61K47/646 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55572 ,  A61K2039/64 ,  Y02A50/474 ,  Y02A50/476 ,  Y02A50/482

    摘要： An artificial invasin complex is prepared from purified or recombinantly prepared invasins and gram negative bacteria lipopolysaccharides. Typically, IpaB is mixed with IpaC to form a IpaB:IpaC complex. This invasin protein complex is then mixed with the lipopolysaccharide to form an artificial invasin complex. Additional bioactive molecules can be incorporated into the complex during manufacture. This artificial invasin complex is similar in function to native Invaplex 24 or Invaplex 50. The artificial invasin complex has superior immunogenicity properties relative to the native complex and can be taylor made. Its method of preparation lends itself to scale up. The artificial invasin complex can facilitate transport of biomolecules, therapeutics and antibiotics across cell membranes in a manner similar to native Shigella Invaplex.

    摘要翻译： 从纯化或重组制备的侵染素和革兰氏阴性细菌脂多糖制备人造侵染素复合物。 通常，IpaB与IpaC混合形成IpaB：IpaC复合体。 然后将这种侵入蛋白复合物与脂多糖混合形成人造侵袭素复合物。 额外的生物活性分子可以在制造期间结合到复合物中。 这种人造侵染素复合物在功能上与天然Invaplex 24或Invaplex 50类似。人造侵染素复合物相对于天然复合物具有优异的免疫原性，并且可以是泰勒制造的。 其制备方法有助于扩大规模。 人造侵染素复合物可以促进生物分子，治疗剂和抗生素以类似于天然志贺氏菌Invaplex的方式跨细胞膜转运。

    Novel P falciparum vaccine proteins and coding sequences
    7.
    发明公开
    Novel P falciparum vaccine proteins and coding sequences 审中-公开
    Neue P-Falciparum-Proteinimpfstoffe und Codiersequenzen

    公开(公告)号：EP2505212A2

    公开(公告)日：2012-10-03

    申请号：EP12158677.0

    申请日：2007-08-29

    申请人： The United States of America as Represented By the Secretary of the Army, Walter Reed Army Institute of Research ,  Kincaid, Randall L.

    发明人： Kincaid, Randall L. ,  Angov, Evelina ,  Lyon, Jeffrey A.

    IPC分类号： A61K48/00

    CPC分类号： C07K14/445

    摘要： The present invention is directed to recombinant DNA technology and immunology, particularly antigens and related vaccines for prevention of malarial infection. The present invention includes novel recombinant malarial proteins, and fragments of the same, that have unique structural and/or chemical properties that allow them to be expressed in greater quantity in heterologous systems. These recombinant proteins and fragments have immunogenic properties superior to malarial proteins expressed using different expression systems and coding sequences, but having the same primary amino acid sequence.

    摘要翻译： 本发明涉及重组DNA技术和免疫学，特别是用于预防疟疾感染的抗原和相关疫苗。 本发明包括具有独特结构和/或化学性质的新型重组疟疾蛋白及其片段，其允许它们在异源系统中以更大的量表达。 这些重组蛋白和片段具有优于使用不同表达系统和编码序列表达的但具有相同的一级氨基酸序列的疟疾蛋白的免疫原性。