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    SELECTIVE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED TRI-NUCLEOTIDE REPEAT CONTAINING GENES
    9.
    发明公开
    SELECTIVE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED TRI-NUCLEOTIDE REPEAT CONTAINING GENES 有权
    剔除ER TION ER EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN

    公开(公告)号：EP2705151A4

    公开(公告)日：2014-10-08

    申请号：EP11847833

    申请日：2011-12-08

    申请人： UNIV LELAND STANFORD JUNIOR ,  UNIV NAT YANG MING

    发明人： CHENG TZU-HAO ,  LIU CHIA-RUNG ,  WANG TZU-HAN ,  COHEN STANLEY N

    IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P25/14

    CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K51/10 ,  A61K51/1075 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023

    摘要： This invention provides a method for modulating the expression of a first gene in a cell wherein the first gene is one containing more than 36 CAG trinucleotide repeats and encoding a protein that form polyglutamine-mediated protein aggregation. Suppression of the first gene is achieved by reducing the expression of SPT4 gene or SUPT4H gene. It can also be achieved by inhibiting the formation of a Spt4/Spt5 complex or a Supt4h/Supt5h complex. Also provided is a method for identifying an agent useful for modulating the expression and aggregation of CAG-expanded gene product, or treating a polyglutamine disease such as Huntington's disease.

    摘要翻译： 本发明提供了调节细胞中第一个基因表达的方法，其中第一个基因是含有多于36个CAG三核苷酸重复序列的基因，并编码形成聚谷氨酰胺介导的蛋白质聚集的蛋白质。 通过降低SPT4基因或SUPT4H基因的表达来实现第一个基因的抑制。 也可以通过抑制Spt4 / Spt5复合物或Supt4h / Supt5h复合物的形成来实现。 还提供了用于鉴定可用于调节CAG扩增的基因产物的表达和聚集或治疗多聚谷氨酰胺疾病如亨廷顿病的药剂的方法。

    EXTRACT OF DIOSCOREA SP. AND THE MEDICAL USES THEREOF
    10.
    发明公开
    EXTRACT OF DIOSCOREA SP. AND THE MEDICAL USES THEREOF 有权
    提取薯SP。 及其医疗用途

    公开(公告)号：EP1978983A4

    公开(公告)日：2010-05-12

    申请号：EP06837661

    申请日：2006-11-15

    申请人： UNIV NAT YANG MING

    发明人： WU RONG-TSUN

    IPC分类号： A61K36/18 ,  A61K36/8945 ,  A23L19/12 ,  A61P19/10 ,  A61P43/00

    CPC分类号： A61K36/8945

    摘要： The present invention provides a method for treating osteoporosis in a subject in need of such treatment, including administering orally to the subject an effective amount of an extract product of a Dioscorea species capable of promoting proliferation and differentiation of bone marrow cells in the subject, wherein the Dioscorea species is characterized by a randomly amplified polymorphic DNA (RAPD) fingerprint including 14 DNA bands ranging from 428 bp, 452 bp, 537 bp, 602 bp, 723 bp, 817 bp, 934 bp, 1140 bp, 1242 bp, 1478 bp, 1641 bp, 1904 bp, 2151 bp and 2918 bp, respectively, when genomic DNA of the Dioscorea species is amplified with a primer of SEQ ID NO: 9, and the extract product is prepared by a process including the steps of: (a) extracting a tuber of the Dioscorea species using an alcohol-based solvent in the presence of acetic acid; (b) subjecting the resultant product obtained in step (a) to a separating treatment to obtain a soluble fraction; and (c) removing solvent from the soluble fraction obtained in step (b) extract fractions of Dioscorea sp.