公开(公告)号：EP3818788A1

公开(公告)日：2021-05-12

申请号：EP19829893.7

申请日：2019-07-04

申请人： Institut National De La Recherche Scientifique ,  University of Saskatchewan

发明人： FOURMAUX, Sylvain ,  KIEFFER, Jean-Claude ,  HALLIN, Emil

IPC分类号： H05G2/00 ,  A01G7/00 ,  G01N23/04 ,  H04N5/32

公开(公告)号：EP2739724B1

公开(公告)日：2018-08-15

申请号：EP12820404.7

申请日：2012-07-31

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： ZHOU, Yan ,  MASIC, Aleksandar

IPC分类号： C12N7/01 ,  A61K39/145 ,  A61P31/16 ,  A61P37/04 ,  C07K14/11 ,  C12N15/44 ,  C12N15/86 ,  C12N5/10 ,  C12N7/04

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16162 ,  C12N2760/16171 ,  C12N2799/025

摘要： Recombinant, chimeric porcine influenza viruses are disclosed that include hemagglutinin segments from more than one influenza virus subtype. Also described are methods of producing the recombinant influenza viruses, immunogenic compositions comprising the recombinant influenza viruses, methods of stimulating an immune response against influenza virus, and methods of treating and preventing influenza virus infection.

公开(公告)号：EP3158331A1

公开(公告)日：2017-04-26

申请号：EP15809628.9

申请日：2015-06-12

申请人： University of Saskatchewan

发明人： TAGHIBIGLOU, Changiz

IPC分类号： G01N33/53 ,  C07K14/47 ,  A61B5/15

CPC分类号： G01N33/6896 ,  A61B5/150022 ,  A61B5/15003 ,  C07K14/47 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/70596 ,  G01N2800/28 ,  G01N2800/2828 ,  G01N2800/40 ,  G01N2800/56

摘要： The disclosure provides methods of detecting and monitoring brain injury in a test subject comprising analyzing a blood sample from the test subject for increased levels of PrPc. The disclosure also provides kits for measuring the amount of PrPc in a blood sample.

摘要翻译： 本公开提供了检测和监测受试对象中脑损伤的方法，包括分析来自受试对象的血液样品中PrPC水平的增加。 本公开还提供了用于测量血液样品中PrPC量的试剂盒。

公开(公告)号：EP1816200B1

公开(公告)日：2016-03-09

申请号：EP07008633.5

申请日：1998-12-11

申请人： MERIAL ,  The Queen's University of Belfast ,  University of Saskatchewan

发明人： Wang, Li ,  Babiuk, Lorne A. ,  Potter, Andrew A. ,  Willson, Phillip

IPC分类号： C12N15/34 ,  C07K14/01 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  C07K16/08 ,  A61K39/12 ,  G01N33/569 ,  C12Q1/68

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2750/10021 ,  C12N2750/10022

公开(公告)号：EP1349570B1

公开(公告)日：2013-11-20

申请号：EP02726978.6

申请日：2002-01-03

申请人： UNIVERSITY OF SASKATCHEWAN ,  THE UNIVERSITY OF BRITISH COLUMBIA

发明人： FINLAY, Brett ,  POTTER, Andrew, A.

IPC分类号： A61K39/108 ,  C07K14/245 ,  C12N1/20 ,  A61P31/04 ,  A61K39/39 ,  C07K1/02 ,  C07K1/34

CPC分类号： A61K39/0258 ,  A61K2039/55566 ,  C07K14/245 ,  Y02A50/474

摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.

公开(公告)号：EP2478090A1

公开(公告)日：2012-07-25

申请号：EP10816527.5

申请日：2010-09-16

申请人： University Of Saskatchewan ,  University of Washington

发明人： KAMINSKYJ, Susan Gail Willets ,  BASINGER, James Frederick ,  BAO, Xiaohui ,  RODRIGUEZ, Russell John ,  REDMAN, Regina Soon

IPC分类号： C12N1/14 ,  B09C1/10 ,  C05F11/08 ,  A01N63/04 ,  A01H17/00

CPC分类号： C12R1/885 ,  A01N63/04 ,  C05F11/08

摘要： A novel strain of
Trichoderma harzianum called TSTh20-1 is described. TSTh20-1 is useful in promoting plant growth, increasing water use efficiency of plants and in remediation of soil or water.

公开(公告)号：EP2437774A1

公开(公告)日：2012-04-11

申请号：EP10782866.7

申请日：2010-06-02

申请人： University of Saskatchewan

发明人： PRASAD, Kailash

IPC分类号： A61K38/17 ,  A61P9/00 ,  G01N33/566

CPC分类号： G01N33/566 ,  A61K31/155 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4184 ,  A61K31/4415 ,  A61K31/519 ,  A61K45/06 ,  G01N2440/38 ,  G01N2800/323 ,  G01N2800/324 ,  A61K2300/00

摘要： The present invention relates to compounds, methods and/or kits for determining and/or predicting and/or treating restenosis in a patient. The patient is a subject suffering from acute coronary syndrome (ACS). The compounds, methods and kits for the diagnosis or prediction of restenosis in the subject relates to the levels of sRAGE, TNF-α, sVCAM-1 or AGE in a serum sample from said subject. Treatment involves administration of agents that increases the amount of sRAGE in a subject and/or decreases the amount of AGE in a subject who has a low level of sRAGE or high ratio of AGE/sRAGE based on a serum measurement.

公开(公告)号：EP2417165A1

公开(公告)日：2012-02-15

申请号：EP10761153.5

申请日：2010-04-06

申请人： UNIVERSITY OF SASKATCHEWAN ,  Bioniche Life Sciences Inc.

发明人： POTTER, Andrew, A. ,  ASPER, David ,  ROGAN, Dragan

IPC分类号： C07K19/00 ,  A61K39/108 ,  A61K39/385 ,  A61P31/04 ,  A61P37/04 ,  C07K14/245

CPC分类号： A61K39/0258 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/6037 ,  C07K16/1232 ,  Y02A50/474

摘要： Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC O157 and at least one other STEC serotype.

公开(公告)号：EP2344522A1

公开(公告)日：2011-07-20

申请号：EP09820153.6

申请日：2009-10-15

申请人： The University of Saskatchewan ,  The University of British Columbia ,  Dalhousie University ,  International Vaccine Institute

发明人： VAN DRUNEN LITTEL-VAN DEN HURK, Sylvia ,  GERDTS, Volker ,  POTTER, Andrew ,  BABIUK, Lorne ,  HANCOCK, Robert ,  HALPERIN, Scott ,  KOVACS-NOLAN, Jennifer ,  MUTWIRI, George ,  LEE, Song ,  KWEON, Mi-Na ,  KINDRACHUK, Jason ,  ELLIOTT, Melissa

IPC分类号： C07K7/08 ,  A61K39/10 ,  A61K39/155 ,  A61K39/39 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

摘要： Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

公开(公告)号：EP2285964A1

公开(公告)日：2011-02-23

申请号：EP09741613.5

申请日：2009-05-11

申请人： University Of Saskatchewan

发明人： HAYES , Sidney

IPC分类号： C12N15/34 ,  C12N15/73 ,  C12N7/00 ,  C40B50/06 ,  A61K39/12 ,  A61K35/76 ,  A61K48/00 ,  C04B40/02

CPC分类号： C12N15/1037 ,  A61K2039/5256 ,  C07K14/005 ,  C07K2319/735 ,  C12N7/00 ,  C12N2795/10321 ,  C12N2795/10322 ,  C40B40/02

摘要： Bacteriophages in general and lambda phage in particular are powerful, flexible reagents who have yet to be exploited to their full potential. As discussed herein, the lambda phage head and/or genome comprises an easy to use and highly efficient delivery vehicle for delivering the expression products of a gene of interest systemically or to a particular tissue.