公开(公告)号：EP2566483B1

公开(公告)日：2019-09-11

申请号：EP11778468.6

申请日：2011-05-06

申请人： University Of Southern California, USC Stevens

发明人： CHEN, Mei ,  WOODLEY, David

IPC分类号： A61K31/7008 ,  A61P17/00 ,  A61K31/7036 ,  A61K38/39

公开(公告)号：EP2144566A2

公开(公告)日：2010-01-20

申请号：EP08799761.5

申请日：2008-04-10

申请人： University Of Southern California USC Stevens

发明人： HUANG, David ,  WANG, Yimin

IPC分类号： A61B8/00

CPC分类号： A61B3/102

摘要： This invention provides methods for non-invasive, real-time measuring and/or monitoring of local blood flow in a subject. Methods of the invention generally include the steps of obtaining Doppler shift images of at least two planes intersecting blood vessels at the scanned location; determining Doppler angles using the Doppler shift images; and then using the Doppler angles thus determined together with the Doppler shift signals to arrive at a measure of the volumetric blood flow. Also provided are systems and software for performing the methods.

公开(公告)号：EP2137536B1

公开(公告)日：2015-03-04

申请号：EP08744408.9

申请日：2008-03-26

申请人： University Of Southern California, USC Stevens

发明人： SCHONTHAL, Axel, H. ,  PETASIS, Nicos, A. ,  HOFMAN, Florence, M. ,  LOUIE, Stan, G. ,  CHEN, Thomas, C.

IPC分类号： G01N33/574 ,  C12N5/00 ,  A61P35/00 ,  A61K31/415 ,  C12N5/09 ,  G01N33/50

CPC分类号： A61K31/635 ,  A61K31/415 ,  A61K31/4188 ,  A61K38/005 ,  A61K38/05 ,  A61N5/10 ,  C12N5/0693 ,  C12N5/0694 ,  C12N2501/48 ,  G01N33/5076 ,  G01N2333/90245 ,  G01N2333/914 ,  G01N2510/00

公开(公告)号：EP2285218A2

公开(公告)日：2011-02-23

申请号：EP09734637.3

申请日：2009-04-24

申请人： University Of Southern California, USC Stevens

发明人： LONGO, Valter

IPC分类号： A01N43/50 ,  A61K31/415

CPC分类号： A61K31/405 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/4172 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/302 ,  A23V2200/308 ,  A23V2250/0632 ,  A23V2250/065 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/063 ,  A23V2250/0638 ,  A23V2250/0648 ,  A23V2250/0654 ,  A23V2250/0604 ,  A23V2250/0606 ,  A23V2250/0608 ,  A23V2250/0616 ,  A23V2250/0618 ,  A23V2250/0622 ,  A23V2250/064 ,  A23V2250/0642 ,  A23V2250/0652 ,  A23V2250/0624

摘要： The present invention relates to dietary compositions comprising reduced level of methionine, tryptophan, all amino acids, or protein, dietary compositions comprising glycerol as a substitute for monosaccharides, disaccharides, and polysaccharides, and hypocaloric or calorie free diets with reduced level of energy, carbohydrates, or protein. Also disclosed are methods of using these compositions and diets, as well as fasting, to protect subjects against chemotherapy, radiotherapy, oxidative stress, or aging.

公开(公告)号：EP3598976A1

公开(公告)日：2020-01-29

申请号：EP19195610.1

申请日：2011-05-06

申请人： University Of Southern California, USC Stevens

发明人： CHEN, Mei ,  WOODLEY, David

IPC分类号： A61K31/7008 ,  A61P17/00 ,  A61K31/7036 ,  A61K38/39

摘要： This invention discloses a method of inducing expression of full-length collagen 7 in cells that contain nonsense mutations in the COL7A1 gene by treating the cell with an aminoglycoside such as G418, gentamicin, and paromomycin. Also provided is a method of treating DEB due to nonsense mutation in the COL7A1 gene by administering a composition containing an effective amount of an aminoglycoside. Also provided is a novel composition useful to treating conditions due to nonsense mutation in the COL7A1 gene, containing an aminoglycoside, a C7, a min-C7 or both; and a pharmaceutically acceptable carrier.

公开(公告)号：EP2291496A2

公开(公告)日：2011-03-09

申请号：EP09770620.4

申请日：2009-05-20

申请人： University Of Southern California, USC Stevens

发明人： OLAH, George, A. ,  PRAKASH, G.K., Surya

IPC分类号： C10L1/182 ,  C10L1/185 ,  C10K3/02

CPC分类号： C10L1/02 ,  G06Q50/06 ,  Y02P30/42

摘要： The present invention relates to a method of stockpiling a fuel source by storing methanol or dimethyl ether in appropriate storage facilities to provide an alternative fuel source that can be used to avoid shortages due to unavailability, limited availability or excessive costs of oil.

公开(公告)号：EP2277229A1

公开(公告)日：2011-01-26

申请号：EP09747511.5

申请日：2009-05-13

申请人： University Of Southern California USC Stevens

发明人： HE, Zhen ,  NEALSON, Kenneth, H. ,  MANSFELD, Florian

IPC分类号： H01M8/16

CPC分类号： H01M8/16 ,  C02F1/46104 ,  C02F3/301 ,  C02F3/302 ,  C02F3/341 ,  C02F2001/46123 ,  C02F2101/16 ,  C02F2101/163 ,  C02F2101/166 ,  Y02E60/527

摘要： A microbial fuel cell for generating electricity. The microbial fuel cell includes an anode and a cathode electrically coupled to the anode. The anode is in contact with a first fluid including microorganisms capable of catalyzing the oxidation of ammonium. The cathode is in contact with a second fluid including microorganisms capable of catalyzing the reduction of nitrite The anode and the cathode may be housed in a single compartment, and the cathode may rotate with respect to the anode. The microbial fuel cell can be used to remove ammonium from wastewater, to generate electricity, or both.

公开(公告)号：EP2566483A1

公开(公告)日：2013-03-13

申请号：EP11778468.6

申请日：2011-05-06

申请人： University Of Southern California, USC Stevens

发明人： CHEN, Mei ,  WOODLEY, David

IPC分类号： A61K31/7008

CPC分类号： A61K31/7036 ,  A61K9/0014 ,  A61K38/39 ,  A61K2300/00

摘要： This invention discloses a method of inducing expression of full-length collagen 7 in cells that contain nonsense mutations in the
COL7A1 gene by treating the cell with an aminoglycoside such as G418, gentamicin, and paromomycin. Also provided is a method of treating DEB due to nonsense mutation in the
COL7A1 gene by administering a composition containing an effective amount of an aminoglycoside. Also provided is a novel composition useful to treating conditions due to nonsense mutation in the
COL7A1 gene, containing an aminoglycoside, a C7, a min-C7 or both; and a pharmaceutically acceptable carrier.

公开(公告)号：EP2137536A1

公开(公告)日：2009-12-30

申请号：EP08744408.9

申请日：2008-03-26

申请人： University Of Southern California USC Stevens

发明人： SCHONTHAL, Axel, H. ,  PETASIS, Nicos, A. ,  HOFMAN, Florence, M. ,  LOUIE, Stan, G. ,  CHEN, Thomas, C.

IPC分类号： G01N33/574 ,  C12N5/00

CPC分类号： A61K31/635 ,  A61K31/415 ,  A61K31/4188 ,  A61K38/005 ,  A61K38/05 ,  A61N5/10 ,  C12N5/0693 ,  C12N5/0694 ,  C12N2501/48 ,  G01N33/5076 ,  G01N2333/90245 ,  G01N2333/914 ,  G01N2510/00

摘要： The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.

公开(公告)号：EP2029156A2

公开(公告)日：2009-03-04

申请号：EP07776668.1

申请日：2007-04-30

申请人： University Of Southern California USC Stevens

发明人： MARKLAND,Jr., Francis, S. ,  SWENSON, Steven ,  PINSKI, Jacek

IPC分类号： A61K38/00

CPC分类号： A61K38/1703

摘要： The invention relates to compositions and methods for treating diseases. In particular aspects, the invention relates to administering a combination of a disintegrin with a microtubule stabilizing agent useful for treatment of cancer.