公开(公告)号：EP3359259A1

公开(公告)日：2018-08-15

申请号：EP16854140.7

申请日：2016-10-03

Applicant: Huizenga, Joel

Inventor： Huizenga, Joel

IPC: A61P39/00 ,  A23L33/13 ,  A23L33/175 ,  A61K36/48

CPC classification number: A23L33/13 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/045 ,  A61K31/198 ,  A61K31/205 ,  A61K31/706 ,  A61K31/714 ,  A61K33/40 ,  A61K36/258 ,  A61K2300/00 ,  A23V2200/302

Abstract: Compositions for addressing one or more of the effects of aging are described. The compositions comprise a first component comprising repair system activator(s) such as nicotinamide adenine dinucleotide (NAD+), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine mononucleotide (NaMN), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid riboside (NAR), 1-methylnicotinamide (MNM), cyclic adenosine monophosphate (cAMP) and combinations thereof; a second component comprising methyl donor(s) such as S-5'-adenosyl-L-methionine (SAM), methionine, betaine, choline, folate, vitamin B12, or combinations thereof; and a third component comprising antioxidant defense activators such as H2O2, N2S, NaSH, Na2S, and several others, including combinations thereof. Methods of administering the disclosed compositions or separate formulations of repair system activator, methyl donors, and antioxidant defense activators are also disclosed.

公开(公告)号：EP3263120A1

公开(公告)日：2018-01-03

申请号：EP17171310.0

申请日：2008-09-17

Applicant: N.V. Nutricia

Inventor： HOIJER, Maarten Anne ,  SIJBEN, Johannes Wilhelmus Christina

IPC: A61K38/00 ,  A23L33/115 ,  A23L33/12 ,  A23L33/13 ,  A23L33/17 ,  A23L33/19 ,  A23L33/21 ,  A23L33/00

CPC classification number: A23L33/21 ,  A23L33/115 ,  A23L33/12 ,  A23L33/13 ,  A23L33/17 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/54 ,  A23V2250/1882 ,  A23V2200/33 ,  A23V2250/51 ,  A23V2250/50 ,  A23V2200/308 ,  A23V2200/302 ,  A23V2200/326

Abstract: The present invention concerns high energy formulations for treatment and/or prevention of faltering growth in infants, in particular for promoting catch-up growth in a sick infant.

Abstract translation: 本发明涉及用于治疗和/或预防婴儿蹒跚生长的高能量制剂，特别是用于促进患病儿童的追赶生长。

公开(公告)号：EP2590521B1

公开(公告)日：2017-02-22

申请号：EP11736184.0

申请日：2011-07-06

Applicant: N.V. Nutricia

Inventor： JOURDAN, Marion-Eve Adeline ,  LUIKING, Yvette Charlotte ,  VERLAAN, George ,  TER BORG, Sovianne

IPC: A23L33/175 ,  A23L33/155 ,  A23L33/00 ,  A61K31/198 ,  A61K31/59 ,  A61P21/06

CPC classification number: A61K31/593 ,  A23L33/155 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/316 ,  A23V2250/0614 ,  A23V2250/0628 ,  A23V2250/306 ,  A23V2250/71 ,  A61K31/198 ,  A61K31/59 ,  A61K31/592 ,  A61K2300/00 ,  A23V2200/302 ,  A23V2250/54252

Abstract: The invention relates to the use of an anabolic amino acid derivative stimulus acting in combination with vitamin D for the manufacture of a medicament or nutritional composition for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal.

Abstract translation: 本发明涉及与维生素D组合起作用的合成代谢氨基酸衍生物刺激物在制备用于预防和/或治疗肌肉量，肌肉力量，肌肉功能中的任何一种的损失的药物或营养组合物中的用途 ，和身体功能，或其任何组合。

公开(公告)号：EP2453759B1

公开(公告)日：2015-10-21

申请号：EP10734871.6

申请日：2010-07-14

Applicant: Hill's Pet Nutrition, Inc.

Inventor： ZICKER, Steven C. ,  GROSS, Kathy Lynn

IPC: A23K1/16 ,  A23K1/18 ,  A61K31/385 ,  A61P39/06

CPC classification number: A61K31/385 ,  A23K20/105 ,  A23K20/121 ,  A23K50/40 ,  A23K50/42 ,  A23V2002/00 ,  A61K9/0056 ,  A23V2200/302 ,  A23V2300/16 ,  A23V2250/026 ,  A23V2250/51084 ,  A23V2250/51082 ,  A23V2250/51088

Abstract: A pet food composition includes lipoic acid. The lipoic acid is incorporated into or onto a substrate, and a sustained-release coating is applied thereto. The composition is useful for providing a sustained release of lipoic acid. The composition may be used in methods for the prevention of cell damage.

公开(公告)号：EP2917220A1

公开(公告)日：2015-09-16

申请号：EP12888056.4

申请日：2012-11-09

Applicant: Cellarouge Pty Ltd.

Inventor： ORCHARD-JARDINE, Katrina Louise ,  JARDINE, Gregory John

IPC: C07D493/22 ,  C07D311/20 ,  C07C49/248 ,  A61K31/366 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61K31/353 ,  A61K31/121

CPC classification number: C07D493/22 ,  A23F3/14 ,  A23F5/00 ,  A23F5/14 ,  A23G3/364 ,  A23L2/02 ,  A23L2/52 ,  A23L7/126 ,  A23L19/01 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/366 ,  A61K36/74 ,  A61K36/82 ,  C07D311/62 ,  C07D311/80 ,  C07H13/08 ,  A23V2200/302 ,  A23V2200/308 ,  A23V2200/326

Abstract: This invention relates to polyphenolic compounds, in particular ethoxylated polyphenolic compounds and the use of such compounds in disease prevention, disease treatment, and life extension in humans and animals. The invention also relates to methods of preparing ethoxylated polyphenolic compounds, and preparation of compositions comprising the compounds, including dietary supplements and foods. The inventors describe how modified C-glycosidic ellagitannins are safe, palatable and effective at medium and high doses, and produce broad and profound health outcomes in mammals.

公开(公告)号：EP2835134A1

公开(公告)日：2015-02-11

申请号：EP14183739.3

申请日：2011-09-15

Applicant: Metsäntutkimuslaitos ,  Cermedi Oy

Inventor： Uusitalo, Hannu ,  Sarjala, Tytti ,  Viitala, Katja ,  Potila, Hannamaria ,  Huhtala, Anne

IPC: A61K36/06 ,  A61P39/06 ,  A23L1/30 ,  C12N1/14 ,  C12N3/00 ,  A61K36/062

CPC classification number: A61K36/062 ,  A23L33/10 ,  A23V2002/00 ,  A61K36/06 ,  C12N1/14 ,  A23V2200/302 ,  A23V2200/322 ,  A23V2200/326 ,  A23V2250/208

Abstract: The present invention relates to compositions and methods of inhibiting, treating or preventing age related or other retinal diseases, neurodegenerative diseases, or heart and vascular diseases. The invention is in the field of dietary (foods and food supplements), nutraceutical and pharmaceutical compositions containing extracts from root-associated fungal species, or single or synergistically functioning multiple compounds therefrom.

Abstract translation: 本发明涉及抑制，治疗或预防年龄相关或其他视网膜疾病，神经变性疾病或心脏和血管疾病的组合物和方法。 本发明涉及饮食（食品和食品补充剂），含有根相关真菌物种的提取物的营养药物和药物组合物，或单一或协同作用的多种化合物。

公开(公告)号：EP2799075A1

公开(公告)日：2014-11-05

申请号：EP12863697.4

申请日：2012-12-27

Applicant: Morishita Jintan Co., Ltd.

Inventor： NISHIDA, Norihisa ,  NAGATOMO, Akifumi ,  ITO, Hideyuki

IPC: A61K31/7024 ,  A23L1/30 ,  A23L1/305 ,  A23L2/52 ,  A61K8/60 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61P3/10 ,  A61P13/12 ,  A61P17/16 ,  A61P25/02 ,  A61P27/02 ,  A61P43/00 ,  A61Q19/08 ,  C07H13/08

CPC classification number: A61K31/7048 ,  A23L2/52 ,  A23L2/66 ,  A23L3/3472 ,  A23L5/27 ,  A23L33/105 ,  A23L33/17 ,  A23V2002/00 ,  A61K8/347 ,  A61K8/498 ,  A61K8/60 ,  A61K31/366 ,  A61K36/185 ,  A61Q19/08 ,  A23V2200/302 ,  A23V2200/328 ,  A23V2250/2132 ,  A23V2250/5422 ,  A61K2300/00

Abstract: Provided are a Maillard reaction inhibitor which effectively inhibits the progress of a Maillard reaction in a living body, and can be safely applied without any adverse side effects and be manufactured without requiring any complicated process, and a skin anti-aging agent, an anti-diabetic complication agent and foods and beverages using the same. The Maillard reaction inhibitor of the present invention contains 50 to 90% by mass of polyphenol as an active ingredient. Since the Maillard reaction inhibitor of the present invention has a potent Maillard reaction inhibitory activity to efficiently inhibit the Maillard reaction in a living body and allow for the prevention and improvement of the various dysfunction of protein in a living body. Due to this activity, the Maillard reaction inhibitor of the present invention suppresses aging and is useful for the prevention and treatment of diabetic complications. Furthermore, when the above-described tannin is mixed in foods and beverages containing collagen, it is possible to suppress the Maillard reaction in the foods and beverages to suppress the deterioration of the foods and beverages, and to also suppress the Maillard reaction in a living body.

Abstract translation: 本发明提供了一种美拉德反应抑制剂，其有效地抑制了生物体中美拉德反应的进行，并且可以安全地施用而没有任何不利的副作用，并且不需要任何复杂的方法制造，并且可以使用皮肤抗老化剂， 糖尿病并发症药物和使用其的食品和饮料。 本发明的美拉德反应抑制剂含有50〜90质量％的多酚作为有效成分。 由于本发明的美拉德反应抑制剂具有有效的美拉德反应抑制活性，能有效地抑制活体中的美拉德反应，并且能够预防和改善生物体内各种蛋白质功能障碍。 由于这种活性，本发明的美拉德反应抑制剂抑制老化，可用于预防和治疗糖尿病并发症。 此外，当将上述单宁混合在含有胶原蛋白的食品和饮料中时，可以抑制食品和饮料中的美拉德反应以抑制食品和饮料的劣化，并且还抑制生活中的美拉德反应 身体。

公开(公告)号：EP2484356A4

公开(公告)日：2013-12-04

申请号：EP10820286

申请日：2010-08-31

Applicant: SHISEIDO CO LTD

Inventor： ASHIDA YUTAKA ,  TAKADA KEIKO ,  YOKOO MIHOSHI ,  TOJO YOSUKE

IPC: A61K31/198 ,  A21D2/24 ,  A23C9/13 ,  A23G3/34 ,  A23L1/20 ,  A23L1/202 ,  A23L1/22 ,  A23L1/238 ,  A23L1/24 ,  A23L1/305 ,  A23L1/48 ,  A23L2/52 ,  A61P17/00 ,  C12C1/00

CPC classification number: A23C9/1322 ,  A21D2/245 ,  A23G3/44 ,  A23L7/20 ,  A23L11/09 ,  A23L27/50 ,  A23L27/60 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/198 ,  A23V2200/302 ,  A23V2250/0618 ,  A23V2200/318

公开(公告)号：EP2484356A1

公开(公告)日：2012-08-08

申请号：EP10820286.2

申请日：2010-08-31

Applicant: Shiseido Company, Ltd.

Inventor： ASHIDA, Yutaka ,  TAKADA, Keiko ,  YOKOO, Mihoshi ,  TOJO, Yosuke

IPC: A61K31/198 ,  A21D2/24 ,  A23C9/13 ,  A23G3/34 ,  A23L1/20 ,  A23L1/202 ,  A23L1/22 ,  A23L1/238 ,  A23L1/24 ,  A23L1/305 ,  A23L1/48 ,  A23L2/52 ,  A61P17/16 ,  C12C1/00

CPC classification number: A23C9/1322 ,  A21D2/245 ,  A23G3/44 ,  A23L7/20 ,  A23L11/09 ,  A23L27/50 ,  A23L27/60 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/198 ,  A23V2200/302 ,  A23V2250/0618 ,  A23V2200/318

Abstract: Provided is a novel composition that acts to inhibit and/or ameliorate wrinkle formation, does not have adverse effects like those of retinoids, and is highly photostable. An oral composition for reducing wrinkle formation and an oral composition for preventing wrinkle formation are provided, said compositions containing at least one compound selected from a group comprising D-glutamic acid and derivatives and/or salts thereof. Also provided are a pharmaceutical composition and a food composition containing the aforementioned oral composition for reducing wrinkle formation or the aforementioned oral composition for preventing wrinkle formation.

Abstract translation: 提供了用于抑制和/或改善皱纹形成的新型组合物，不具有类似类维生素A的不利影响，并且是高度光稳定的。 提供了用于减少皱纹形成的口腔组合物和用于预防皱纹形成的口腔组合物，所述组合物含有至少一种选自D-谷氨酸及其衍生物和/或盐的化合物。 还提供了含有上述用于减少皱纹形成的口腔组合物的药物组合物和食品组合物，或上述用于防止皱纹形成的口腔组合物。

公开(公告)号：EP2244591A1

公开(公告)日：2010-11-03

申请号：EP08864664.1

申请日：2008-12-22

Applicant: N.V. Nutricia

Inventor： DE KORT, Esther Jacqueline ,  GROENENDIJK, Martine ,  KAMPHUIS, Patrick Joseph Gerardus Hendrikus

IPC: A23L1/0522 ,  A23L1/0526 ,  A23L1/0528 ,  A23L1/053 ,  A23L1/0532 ,  A23L1/0534 ,  A23L1/30 ,  A61K31/7052 ,  A61K31/7072 ,  A61K35/60 ,  A61K47/36 ,  A61K47/38 ,  A23L1/22 ,  A61P25/28 ,  A61K9/00

CPC classification number: A61K47/38 ,  A23L29/262 ,  A23L29/269 ,  A23L29/272 ,  A23L33/115 ,  A23L33/13 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/7052 ,  A61K31/7072 ,  A61K33/06 ,  A61K35/60 ,  A61K38/02 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2200/302 ,  A23V2250/712 ,  A23V2250/708 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/714 ,  A23V2250/702 ,  A23V2250/72 ,  A23V2250/1588 ,  A23V2250/1614 ,  A23V2250/1608 ,  A23V2250/1612 ,  A23V2250/1642 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/51082 ,  A23V2250/54246 ,  A23V2250/54252 ,  A23V2250/628 ,  A23V2250/5114

Abstract: The invention pertains to a liquid composition for preventing and/or treating memory decline and/or cognitive dysfunction, Alzheimer's, Parkinson's and/or dementia, said composition comprising: (i) at least 50 mg nucleoside and/or nucleotide per 100 ml; (ii) between 0.2 and 10 grams protein per 100 ml; (iii) between 0.05 and 3 wt.% of thickener, based on total weight of the composition. The thickener is preferably selected from the group consisting of cellulose, xanthan gum, gellan gum, alginate, guar gum, locust bean gum, gum karaya, gum tragacanth, carrageenan, and mixtures thereof. The composition preferably has a loss factor tan ´ between 0.1 and 100, as measured at any strain in the range of 1 - 100 % at 0.1 Hz and 20 °C. It is particularly found that a thickener selected from the group consisting of gellan gum, xanthan gum and cellulose greatly reduces sedimentation.

Abstract translation: 本发明涉及一种液体组合物，用于预防和/或治疗记忆衰退和/或认知功能障碍，阿尔茨海默病，帕金森病和/或痴呆，所述组合物包含：（i）至少50个毫克的核苷和/或每100毫升的核苷酸; （二）每100毫升0.2克和10之间的蛋白质; （三）0:05和3％（重量）增稠剂之间，基于组合物的总重量。 增稠剂优选选自纤维素，黄原胶，结冷胶，藻酸盐，瓜尔胶，刺槐豆胶，刺梧桐树胶，黄蓍胶，角叉菜胶，以及它们的混合物中选择。 所述组合物优选具有0.1到100之间的损耗角正切”，因为在1范围内的任何应变测量 - 在0.1 Hz和20℃下100％ 它特别发现确实选自洁冷胶，黄原胶和纤维素中选择的增稠剂大大减少沉积物堆积。