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公开(公告)号：EP3311166A1
公开(公告)日：2018-04-25
申请号：EP16736007.2
申请日：2016-06-17
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , G01N2333/726 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Disclosed is the use of latrophilin expression as a biomarker for the diagnosis of haematopoietic cell cancer in a subject, together with methods for diagnosis and a kit for the detection of latrophilin expression on white blood cells collected from a subject.
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公开(公告)号：EP2760883A1
公开(公告)日：2014-08-06
申请号：EP12777872.8
申请日：2012-09-27
CPC分类号： C12P3/00 , A23L33/135 , A61K38/45 , C07K14/195 , C12N1/20 , C12N9/1229 , C12N15/70 , C12P21/00 , C12Y207/04001 , Y02A50/473
摘要： A non-therapeutic method of accumulating a polymeric or high molecular weight molecular product within a bacterial microcompartment in bacterial cytoplasm, which method employs a recombinant bacteria which is genetically engineered to express a microcompartment containing an enzyme capable of converting a low molecular weight substrate into a polymeric or high molecular weight product, the method comprising the steps of: incubating the recombinant bacteria with the low-molecular weight substrate, or a precursor of the low molecular weight substrate which is capable of being metabolised to the substrate within the recombinant bacteria, such that the substrate or precursor is taken up by the bacteria, wherein the substrate enters the microcompartment and the enzyme within the microcompartment converts the substrate to a polymeric or high molecular weight molecular product, and wherein the polymeric or high molecular weight molecular product is accumulated within the microcompartment due to its size.
摘要翻译： 在细菌细胞质中在细菌微室内积聚聚合物或高分子量分子产物的非治疗方法，该方法使用重组细菌，其被遗传工程化以表达含有能够将低分子量底物转化为 聚合物或高分子量产物，该方法包括以下步骤：将重组细菌与低分子量底物或低分子量底物的前体一起孵育，该前体能够被代谢至重组细菌内的底物，如 底物或前体被细菌吸收，其中基质进入微室，微室内的酶将底物转化为聚合物或高分子量分子产物，并且其中聚合或高分子量分子产物积聚在 微型房间到期 到它的大小。
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公开(公告)号：EP2396855A1
公开(公告)日：2011-12-21
申请号：EP10710893.8
申请日：2010-02-11
申请人： University of Kent
IPC分类号： H01Q15/00
CPC分类号： H01Q15/0066
摘要： An electronically tuneable surface. The surface comprises: a conductive sheet comprising at least one opening; and a biasing circuit. The biasing circuit comprises first and second conductors, separated from the conductive sheet by a dielectric, and arranged at mutually opposing sides of the opening such that each conductor is capacitively coupled to the conductive sheet at the respective side of the opening. The conductors define a gap between them corresponding to the opening. The biasing circuit also comprises an electrical control element bridging the gap, connected to the first and second conductors. When the element is in a first state, the surface exhibits a first frequency transmission characteristic with respect to incident electromagnetic radiation, and when the element is in a second state, the surface exhibits a second, different characteristic.
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公开(公告)号：EP1682163A1
公开(公告)日：2006-07-26
申请号：EP04798498.4
申请日：2004-11-10
申请人： University of Kent
IPC分类号： A61K38/16 , A61K39/106 , A61K39/40 , G01N33/50 , A61P31/00
CPC分类号： A61K38/164 , A61K39/107 , C07K16/1239 , Y02A50/472
摘要： The invention relates to a method of regulating quorum sensing in bacteria by modulating the activation of LuxR or a homologue thereof. Such modulation generally occurs when the bacteria are in the pre-quorate or quorate stage and may be achieved by targeting antibodies to LuxR or a homologue thereof.
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公开(公告)号：EP2888246B1
公开(公告)日：2017-12-13
申请号：EP13756924.0
申请日：2013-08-22
发明人： HALL, Andrew
IPC分类号： C07D213/75 , C08F222/14 , G01N33/82
CPC分类号： C08F222/14 , C07D213/75 , C08F226/06 , G01N33/82
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公开(公告)号：EP2984114A1
公开(公告)日：2016-02-17
申请号：EP14711160.3
申请日：2014-03-18
IPC分类号： C08F293/00 , C08F265/06 , G02F1/167 , C08F287/00
CPC分类号： C08F299/04 , C08F2/14 , C08F265/06 , C08F287/00 , C08F293/005 , G02F2001/1678
摘要： This invention relates to polymer particles, a process for their preparation, the use of these particles for the preparation of an electrophoretic device, electrophoretic displays comprising such particle, and new copolymer stabilizers.
摘要翻译： 本发明涉及聚合物颗粒，其制备方法，这些颗粒在制备电泳装置中的用途，包含这种颗粒的电泳显示器和新型共聚物稳定剂。
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公开(公告)号：EP1706114B1
公开(公告)日：2012-12-26
申请号：EP05711707.9
申请日：2005-01-20
IPC分类号： A61K31/415 , A61P25/28 , A61P25/02 , A61P33/06 , A61P31/10 , A61P15/16 , A61P3/10 , A61P5/50 , A61P3/00 , A61P11/00 , A61K31/4184 , C12Q1/527
CPC分类号： A61K31/415 , A61K31/4184 , C12Q1/527 , G01N2333/988 , Y02A50/411
摘要： The present invention relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject. The method involves administering to a subject an effective amount of a compound disclosed herein that modulates soluble adenylyl cyclase, under conditions effective to treat the disorder mediated by soluble adenylyl cyclase. The present invention also relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject, where the disorder is selected from the group consisting of: learning or memory disorders, malaria, fungal infection, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, and peripheral neuropathy. The method involves modulating soluble adenylyl cyclase in the subject. Another aspect of the present invention relates to a method of modulating soluble adenylyl cyclase. The method involves contacting eukaryotic cells with a compound that modulates soluble adenylyl cyclase, under conditions effective to modulate soluble adenylyl cyclase.
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公开(公告)号：EP2044557B1
公开(公告)日：2010-10-27
申请号：EP07804012.8
申请日：2007-07-03
申请人： University of Kent
IPC分类号： G06K9/62
CPC分类号： G06K9/6247 , G06K9/00885
摘要： A method is provided for deriving a single code from a biometric sample in a way which enables different samples of a user to provide the same code whilst also distinguishing between samples of different users. Different features are analysed to obtain mean and variance values, and these are used to control how the different feature values are interpreted. In addition, features are combined and a sub-set of bits of the combination is used as the code. This enables bits which are common to all user samples to be dropped as well as bits which may differ between different samples of the same user.
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公开(公告)号：EP2044557A1
公开(公告)日：2009-04-08
申请号：EP07804012.8
申请日：2007-07-03
申请人： University of Kent
IPC分类号： G06K9/62
CPC分类号： G06K9/6247 , G06K9/00885
摘要： A method is provided for deriving a single code from a biometric sample in a way which enables different samples of a user to provide the same code whilst also distinguishing between samples of different users. Different features are analysed to obtain mean and variance values, and these are used to control how the different feature values are interpreted. In addition, features are combined and a sub-set of bits of the combination is used as the code. This enables bits which are common to all user samples to be dropped as well as bits which may differ between different samples of the same user.
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10.发明公开METHOD FOR INCREASING PRODUCTION OF DISULFIDE BONDED RECOMBINANT PROTEINS BY $i(SACCHAROMYCES CEREVISIAE) 失效法提高重组蛋白的产量二硫键连接-i（酿酒酵母）
公开(公告)号：EP0746611A1
公开(公告)日：1996-12-11
申请号：EP93915201.0
申请日：1993-06-02
发明人： TUITE, Michael F. , FREEDMAN, Robert B. , SCHULTZ, Loren, D. , ELLIS, Ronald, W. , MARKUS, Henry, Z. , MONTGOMERY, Donna, L.
CPC分类号： C12N9/90 , C07K14/811 , C07K14/815 , C12N15/81
摘要： Disclosed is a process for increasing the yield of disulfide bonded recombinant proteins produced by yeast, especially recombinant secreted proteins. The enzyme protein disulfide isomerase (PDI) catalyzes the formation of disulfide bonds in secretory and cell-surface proteins. We disclose the construction of recombinant strains of the yeast Saccharomyces cerevisiae which overproduce either human PDI or yeast PDI in a regulated fashion. These strains show greatly increased secretion of disulfide bonded proteins of potential therapeutic significance. These strains have the potential to increase the production of various disulfide bonded proteins.
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