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    SELF-ASSEMBLING PEPTIDE COMPOSITIONS
    4.
    发明公开
    SELF-ASSEMBLING PEPTIDE COMPOSITIONS 审中-公开

    公开(公告)号：EP3466965A1

    公开(公告)日：2019-04-10

    申请号：EP18203220.1

    申请日：2015-03-10

    申请人： 3-D Matrix Ltd.

    发明人： GIL, Eun Seok ,  GILBERT, Karl ,  MEHTA, Manav

    IPC分类号： C07K7/08 ,  A61L27/22 ,  A61K38/12 ,  A61L27/54 ,  A61L27/58

    摘要： The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).

    SELF-ASSEMBLING PEPTIDE COMPOSITIONS
    6.
    发明公开
    SELF-ASSEMBLING PEPTIDE COMPOSITIONS 审中-公开
    SELBSTANORDNENDE PEPTIDZUSAMMENSETZUNGEN

    公开(公告)号：EP3116896A1

    公开(公告)日：2017-01-18

    申请号：EP15719023.2

    申请日：2015-03-10

    申请人： 3-D Matrix Ltd.

    发明人： GIL, Eun Seok ,  GILBERT, Karl ,  MEHTA, Manav

    IPC分类号： C07K7/08 ,  A61L27/22 ,  A61K38/12 ,  A61L27/54 ,  A61L27/58

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61L24/108 ,  A61L27/227

    摘要： The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).

    摘要翻译： 本公开提供具有特别有用的材料性质的特定属性（例如，肽同一性，肽浓度，pH，离子强度（包括盐同一性和/或浓度）等）的肽组合物（例如自组装肽）。 本公开还提供了用于选择和/或制定在特定上下文中有用的特定肽组合物的技术。 在一些实施方案中，所提供的肽组合物具有在约2.5至约3.5范围内的升高的pH值和/或离子强度高于相同肽在相同浓度，但在水中的相应组合物的离子强度 肽的关键盐点（例如，使得组合物不浑浊）。