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1.发明授权INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES 有权茚并[1,2-C] - 萘并[1,2-C] - 和苯并[6,7]环庚并[1,2-c]吡唑衍生物
公开(公告)号：EP1023063B1
公开(公告)日：2003-09-10
申请号：EP98951011.0
申请日：1998-10-06
申请人： ABBOTT GmbH & Co. KG
发明人： ARNOLD, Lee, D. , XU, Yajun , BARLOZZARI, Teresa
IPC分类号： A61K31/415 , A61K31/44 , C07D401/04 , C07D409/04 , C07D231/56 , C07D405/04 , C07D231/54
CPC分类号： C07D401/04 , A61K31/416 , A61K31/4439 , C07D231/54 , C07D231/56 , C07D405/04 , C07D409/04
摘要： Chemical compounds that are derivatives of indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in hyperproliferative, angiogenic or in vascular hyperpermeability processes. Thus, these chemical compounds can ameliorate disease states where tumor formation, metastasis, angiogenesis, vascular hyperpermeability or endothelial cell proliferation is a factor.
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公开(公告)号：EP1212327B8
公开(公告)日：2004-02-25
申请号：EP00963554.1
申请日：2000-09-15
申请人： Abbott GmbH & Co. KG
发明人： HIRST, Gavin, C. , CALDERWOOD, David , WISHART, Neil , RAFFERTY, Paul , RITTER, Kurt , ARNOLD, Lee, D. , FRIEDMAN, Michael, M.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , C07F9/6561
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公开(公告)号：EP1114052B1
公开(公告)日：2005-11-16
申请号：EP99969414.4
申请日：1999-09-17
申请人： Abbott GmbH & Co. KG
发明人： CALDERWOOD, David , ARNOLD, Lee, D. , MAZDIYASNI, Hormoz , HIRST, Gavin , DENG, Bojuan, B. , TWIGGER, Helen, L. , MUNSCHAUER, Rainer , RAFFERTY, Paul , TOMETZKI, Gerald, B. , JOHNSTON, David, N.
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04
摘要： Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferative is a factor. These compounds can be used to treat cancer, hyperproliferation disorders, rheumatoid arthritis, disorders of the immune system, transplant rejection, and inflammatory disorders.
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公开(公告)号：EP1385524A1
公开(公告)日：2004-02-04
申请号：EP02746301.7
申请日：2002-03-22
申请人： Abbott GmbH & Co. KG
发明人： HIRST, Gavin, C. , RAFFERTY, Paul , RITTER, Kurt , CALDERWOOD, David , WISHART, Neil , ARNOLD, Lee, D. , FRIEDMAN, Michael, M.
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , C07F9/6561
摘要： The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R2, and R3 are defined as described herein.
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5.发明公开2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS 审中-公开2 BENZOTHIAZOLYLHARNSTOFF衍生物及其作为激酶抑制剂的蛋白质
公开(公告)号：EP1254123A1
公开(公告)日：2002-11-06
申请号：EP01908878.0
申请日：2001-02-06
申请人： Abbott GmbH & Co. KG
IPC分类号： C07D277/82 , C07D417/04 , C07D417/12 , C07D417/06 , C07D453/02 , C07D451/02 , C07D451/14 , C07D513/04 , C07D487/08 , A61K31/428 , A61K31/435 , A61K31/53 , A61P35/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D451/04 , C07D451/14 , C07D453/02 , C07D487/08 , C07D513/04
摘要： The present invention is directed to a compound of formula (I), racemic-diastereomeric mixtures thereof, optical isomers thereof, prodrugs thereof, isotopes thereof or pharmaceutically-acceptable salts of said compound, isomers, prodrugs and isotopes, wherein the variable are defined herein. The compounds of this invention are useful as inhibitors of serine/threonine and tyrosine kinases. In particular, compounds of this invention are useful as inhibitors of tyrosine kinases that are important in hyperproliferative diseases, especially in cancer and in the process of angiogenesis.
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6.发明公开TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开TRIZYKLISCHE PYRAZOL-DERIVATE ALS PROTEINKINASEHEMMER
公开(公告)号：EP1289525A2
公开(公告)日：2003-03-12
申请号：EP01937553.4
申请日：2001-05-17
申请人： Abbott GmbH & Co. KG
发明人： DOYLE, Kevin, J. , RAFFERTY, Paul , STEELE, Robert, W. , WILKINS, David, J. , ARNOLD, Lee, D. , HOCKLEY, Michael , ERICSSON, Anna, M. , IWASAKI, Nobuhiko , OGAWA, Nobuo
IPC分类号： A61K31/416 , A61K31/4162 , A61P35/00 , C07D231/54 , C07D403/10 , C07D401/12 , C07D451/04 , C07D495/04 , C07D403/12 , C07D401/06 , C07D409/14 , C07D409/04
CPC分类号： C07D401/04 , C07D231/54 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D409/04 , C07D409/14 , C07D417/12 , C07D451/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of formula I which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.
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