公开(公告)号：EP2411352A2

公开(公告)日：2012-02-01

申请号：EP10722455.2

申请日：2010-03-25

申请人： Abbott Laboratories

发明人： BETEBENNER, David, A. ,  PRATT, John, K. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  LIU, Dachun

IPC分类号： C07C15/58 ,  C07D239/54 ,  C07D409/10 ,  C07D213/64 ,  C07D263/22 ,  C07D207/27 ,  C07D233/32 ,  C07D275/02 ,  A61P31/14 ,  C07D233/74 ,  C07D403/10 ,  A61K31/513 ,  C07D239/10 ,  C07D405/10 ,  A61K31/4412

CPC分类号： C07D409/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/402 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4418 ,  A61K31/503 ,  A61K31/513 ,  A61K45/06 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D263/24 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  Y02P20/55

摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

摘要翻译： 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备此类中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：EP1979348A2

公开(公告)日：2008-10-15

申请号：EP06848055.7

申请日：2006-12-20

申请人： ABBOTT LABORATORIES

发明人： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith,F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP2421845A1

公开(公告)日：2012-02-29

申请号：EP10712220.2

申请日：2010-03-25

申请人： Abbott Laboratories

发明人： ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  DEGOEY, David A. ,  FLENTGE, Charles A. ,  HUTCHINSON, Douglas K. ,  KATI, Warren M. ,  KRUEGER, Allan C. ,  LIU, Dachun ,  LONGENECKER, Kenton L. ,  PRATT, John K. ,  STEWART, Kent D. ,  WAGNER, Rolf ,  MARING, Clarence, J.

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07D401/04 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14

摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：EP1560827A1

公开(公告)日：2005-08-10

申请号：EP03768559.1

申请日：2003-10-31

申请人： Abbott Laboratories

发明人： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC分类号： C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC分类号： C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP2421845B1

公开(公告)日：2013-04-17

申请号：EP10712220.2

申请日：2010-03-25

申请人： Abbott Laboratories

发明人： ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  DEGOEY, David A. ,  FLENTGE, Charles A. ,  HUTCHINSON, Douglas K. ,  KATI, Warren M. ,  KRUEGER, Allan C. ,  LIU, Dachun ,  LONGENECKER, Kenton L. ,  PRATT, John K. ,  STEWART, Kent D. ,  WAGNER, Rolf ,  MARING, Clarence, J.

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07D401/04 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14

公开(公告)号：EP2203431B1

公开(公告)日：2011-08-10

申请号：EP08832330.8

申请日：2008-09-17

申请人： Abbott Laboratories

发明人： FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

IPC分类号： C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：EP1560827B1

公开(公告)日：2010-12-29

申请号：EP03768559.1

申请日：2003-10-31

申请人： ABBOTT LABORATORIES

发明人： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC分类号： C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC分类号： C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP1979348B1

公开(公告)日：2012-01-18

申请号：EP06848055.7

申请日：2006-12-20

申请人： ABBOTT LABORATORIES

发明人： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith,F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP2203431A1

公开(公告)日：2010-07-07

申请号：EP08832330.8

申请日：2008-09-17

申请人： Abbott Laboratories

发明人： FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

IPC分类号： C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：EP1087938A1

公开(公告)日：2001-04-04

申请号：EP99918495.5

申请日：1999-04-12

申请人： ABBOTT LABORATORIES

发明人： MARING, Clarence, J. ,  GU, Yu-Gui ,  CHEN, Yuanwei ,  DEGOEY, David, A. ,  GIRANDA, Vincent, L. ,  GRAMPOVNIK, David, J. ,  KATI, Warren, M. ,  KEMPF, Dale, J. ,  KENNEDY, April ,  LIN, Zhen ,  MADIGAN, Darold, L. ,  MUCHMORE, Steven, W. ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  SUN, Minghua ,  WANG, Gary, T. ,  WANG, Sheldon ,  YEUNG, Ming, C.

IPC分类号： C07C271/24 ,  C07C233/52 ,  C07C233/47 ,  C07C271/22 ,  C07D233/54 ,  C07D263/32 ,  A61K31/33 ,  A61K31/16 ,  C07C237/24 ,  C07D307/24 ,  C07D405/04

CPC分类号： C07D233/64 ,  C07C233/52 ,  C07C237/24 ,  C07C271/24 ,  C07C2601/08 ,  C07D307/24 ,  C07D317/32 ,  C07D493/08

摘要： Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

摘要翻译： 公开了式（I），（II）或（III）的化合物，其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。