公开(公告)号：EP1979348A2

公开(公告)日：2008-10-15

申请号：EP06848055.7

申请日：2006-12-20

申请人： ABBOTT LABORATORIES

发明人： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith,F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP1560827B1

公开(公告)日：2010-12-29

申请号：EP03768559.1

申请日：2003-10-31

申请人： ABBOTT LABORATORIES

发明人： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC分类号： C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC分类号： C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP1979348B1

公开(公告)日：2012-01-18

申请号：EP06848055.7

申请日：2006-12-20

申请人： ABBOTT LABORATORIES

发明人： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith,F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP1560827A1

公开(公告)日：2005-08-10

申请号：EP03768559.1

申请日：2003-10-31

申请人： Abbott Laboratories

发明人： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC分类号： C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC分类号： C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP1226146A2

公开(公告)日：2002-07-31

申请号：EP00976992.8

申请日：2000-11-06

申请人： ABBOTT LABORATORIES

发明人： ELMORE, Steven, W. ,  COOPER, Curt, S. ,  SCHULTZ, Colleen, C. ,  HUTCHINSON, Douglas, K. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  ANDERSON, David D. ,  XIE, Qinghua ,  DINGES, Jurgen ,  LYNCH, Linda, M.

IPC分类号： C07D495/04 ,  A61K31/4709 ,  A61P31/04 ,  C07D519/00 ,  C07D471/04 ,  C07D409/04 ,  C07D409/14 ,  C07D513/04 ,  C07D417/14 ,  C07D413/14 ,  C07D417/04

CPC分类号： C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds having formula (I), or pharmaceutically acceptable salts or prodrugs thereof, wherein A1 is nitrogen or (II), wherein W is selected from the group consisting of (1) hydrogen and (2) optionally substituted alkyl; A2 is selected from the group consisting of (1) -S-, (2) -O-, and (3) -N(R7)-, wherein R7 is hydrogen or C¿1?-C6 alkyl; and R?5 and R6¿ together are a carbocyclic or a heterocyclic ring, are useful as antibacterial agents.