公开(公告)号：EP2245020A2

公开(公告)日：2010-11-03

申请号：EP08866836.3

申请日：2008-12-19

申请人： Abbott Laboratories

发明人： FAGHIH, Ramin ,  GFESSER, Gregory, A. ,  MORTELL, Kathleen, H. ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D277/02 ,  C07D277/50 ,  A61P25/00

CPC分类号： C07D277/18 ,  C07D401/02 ,  C07D417/02 ,  C07D417/14

摘要： The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.

公开(公告)号：EP1664045A1

公开(公告)日：2006-06-07

申请号：EP04784568.0

申请日：2004-09-17

申请人： ABBOTT LABORATORIES

发明人： BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R. ,  LI, Tao

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D471/08 ,  A61K31/435 ,  A61P25/00

CPC分类号： C07D487/08 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：EP1509213A2

公开(公告)日：2005-03-02

申请号：EP03755402.9

申请日：2003-05-19

申请人： Abbott Laboratories

发明人： BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  HAKEEM, Ahmed, A. ,  KOLASA, Teodozyj ,  MATULENKO, Mark, A. ,  MORTELL, Kathleen, H. ,  PATEL, Meena, V. ,  STEWART, Andrew, O. ,  WANG, Xueqing ,  XIA, Zhiren ,  ZHANG, Henry, Q.

IPC分类号： A61K31/00

CPC分类号： A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506

摘要： The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP1896469A2

公开(公告)日：2008-03-12

申请号：EP06784857.2

申请日：2006-06-14

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  LI, Tao ,  MORTELL, Kathleen, H. ,  SCHRIMPF, Michael, R. ,  NERSESIAN, Diana, L. ,  PAN, Liping ,  BUNNELLE, William, H.

IPC分类号： C07D453/02 ,  A61P25/28 ,  A61K31/439

CPC分类号： C07D453/02

摘要： Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, -NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.